Database Query Results : , , HDAC10

HDAC10, HDAC10: Click to Expand ⟱
Source:
Type:
HDAC10 (a member of the histone deacetylase family)
• HDAC10 is involved in chromatin remodeling, gene expression, DNA repair, and autophagy.
• Its activity may influence tumor cell survival, invasiveness, and resistance to therapy through regulation of these pathways.

HDAC10 appears to play a context-dependent role in various cancers. In several studies—particularly in ovarian and lung cancers—elevated HDAC10 expression has been associated with poorer clinical outcomes, including chemoresistance and increased tumor aggressiveness.
Scientific Papers found: Click to Expand⟱
1532- Ba,    Baicalein as Promising Anticancer Agent: A Comprehensive Analysis on Molecular Mechanisms and Therapeutic Perspectives
- Review, NA, NA
ROS↑, ER Stress↑, Ca+2↑, MMPs↓, Cyt‑c↑, Casp3↑, ROS↑, DR5↑, ROS↑, BAX↑, Bcl-2↓, MMP↓, Casp3↑, Casp9↑, P53↑, p16↑, P21↑, p27↑, HDAC10↑, MDM2↓, Apoptosis↑, PI3K↓, Akt↓, p‑Akt↓, p‑mTOR↓, NF-kB↓, p‑IκB↓, IκB↑, BAX↑, Bcl-2↓, ROS⇅, BNIP3↑, p38↑, 12LOX↓, Mcl-1↓, Wnt?, GLI2↓, AR↓, eff↑,
2290- Ba,    Research Progress of Scutellaria baicalensis in the Treatment of Gastrointestinal Cancer
- Review, GI, NA
p‑mTOR↓, p‑Akt↓, p‑IKKα↓, NF-kB↓, PI3K↓, Akt↓, ROCK1↓, GSK‐3β↓, CycB/CCNB1↓, cycD1/CCND1↓, cycA1/CCNA1↑, CDK4↓, P53↑, P21↑, TumCCA↑, MMP2↓, MMP9↓, EMT↓, Hif1a↓, Shh↓, PD-L1↓, STAT3↓, IL1β↓, IL2↓, IL6↓, PKM2↓, HDAC10↓, P-gp↓, Bcl-xL↓, eff↓, BioAv↓, BioAv↑,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

ROS↑, 3,   ROS⇅, 1,  

Mitochondria & Bioenergetics ⓘ

MMP↓, 1,  

Core Metabolism/Glycolysis ⓘ

12LOX↓, 1,   PKM2↓, 1,  

Cell Death ⓘ

Akt↓, 2,   p‑Akt↓, 2,   Apoptosis↑, 1,   BAX↑, 2,   Bcl-2↓, 2,   Bcl-xL↓, 1,   Casp3↑, 2,   Casp9↑, 1,   Cyt‑c↑, 1,   DR5↑, 1,   Mcl-1↓, 1,   MDM2↓, 1,   p27↑, 1,   p38↑, 1,  

Protein Folding & ER Stress ⓘ

ER Stress↑, 1,  

Autophagy & Lysosomes ⓘ

BNIP3↑, 1,  

DNA Damage & Repair ⓘ

p16↑, 1,   P53↑, 2,  

Cell Cycle & Senescence ⓘ

CDK4↓, 1,   cycA1/CCNA1↑, 1,   CycB/CCNB1↓, 1,   cycD1/CCND1↓, 1,   P21↑, 2,   TumCCA↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

EMT↓, 1,   GSK‐3β↓, 1,   HDAC10↓, 1,   HDAC10↑, 1,   p‑mTOR↓, 2,   PI3K↓, 2,   Shh↓, 1,   STAT3↓, 1,   Wnt?, 1,  

Migration ⓘ

Ca+2↑, 1,   GLI2↓, 1,   MMP2↓, 1,   MMP9↓, 1,   MMPs↓, 1,   ROCK1↓, 1,  

Angiogenesis & Vasculature ⓘ

Hif1a↓, 1,  

Barriers & Transport ⓘ

P-gp↓, 1,  

Immune & Inflammatory Signaling ⓘ

p‑IKKα↓, 1,   IL1β↓, 1,   IL2↓, 1,   IL6↓, 1,   IκB↑, 1,   p‑IκB↓, 1,   NF-kB↓, 2,   PD-L1↓, 1,  

Hormonal & Nuclear Receptors ⓘ

AR↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 1,   BioAv↑, 1,   eff↓, 1,   eff↑, 1,  

Clinical Biomarkers ⓘ

AR↓, 1,   IL6↓, 1,   PD-L1↓, 1,  
Total Targets: 62

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: HDAC10, HDAC10
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1127  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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