Database Query Results : , , CRT

CRT, calreticulin: Click to Expand ⟱
Source:
Type:
Calreticulin (CRT) is a multifunctional protein principally located in the endoplasmic reticulum (ER), where it plays key roles in calcium homeostasis, protein folding, and quality control. It has also emerged as an important player in cancer biology and immunogenic cell death.

CRT expression can be upregulated in certain cancers, where it may be associated with an active unfolded protein response (UPR) or stress conditions in the tumor microenvironment.

-In some cancers, elevated CRT expression has been correlated with improved outcomes due to its role in enhancing immunogenic cell death. For instance, when CRT is externalized on the surface of dying tumor cells, it can facilitate a robust anti-tumor immune response.
-Conversely, in other cancer types, high CRT levels may be associated with tumor progression, metastasis, or poor clinical outcomes—likely because CRT might also contribute to tumor cell migration or cell survival under stressful conditions.
Scientific Papers found: Click to Expand⟱
1601- Cu,    The copper (II) complex of salicylate phenanthroline induces immunogenic cell death of colorectal cancer cells through inducing endoplasmic reticulum stress
- in-vitro, CRC, NA
i-CRT↓, ICD↑, i-ATP↓, i-HMGB1↓, ER Stress↑, ROS↑, DCells↑, CD8+↑, IL12↑, IFN-γ↑, TGF-β↓,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

ICD↑, 1,   ROS↑, 1,  

Mitochondria & Bioenergetics ⓘ

i-ATP↓, 1,  

Protein Folding & ER Stress ⓘ

i-CRT↓, 1,   ER Stress↑, 1,  

Migration ⓘ

TGF-β↓, 1,  

Immune & Inflammatory Signaling ⓘ

DCells↑, 1,   i-HMGB1↓, 1,   IFN-γ↑, 1,   IL12↑, 1,  

Infection & Microbiome ⓘ

CD8+↑, 1,  
Total Targets: 11

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: CRT, calreticulin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1149  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

Home Page