Database Query Results : , , GSTs

GSTs, Glutathione S-transferases: Click to Expand ⟱
Source:
Type:
Glutathione S-transferases (GSTs) are a family of phase II detoxification enzymes that play key roles in catalyzing the conjugation of glutathione (GSH) to a wide range of electrophilic compounds. This family includes multiple isoenzymes (e.g., GST-α, GST-μ, GST-π) with tissue-specific expression patterns and overlapping as well as distinct substrate specificities.

-GSTs are important for detoxifying potentially harmful compounds, including products of oxidative stress, environmental toxins, and chemotherapeutic agents.
-They contribute to the cellular defense mechanism against oxidative damage and help maintain cellular redox balance.
-Beyond detoxification, GSTs can modulate cell signaling pathways, potentially affecting cell proliferation, apoptosis, and drug resistance.

-GST-π is commonly upregulated in several cancers such as breast, lung, colorectal, and hematologic malignancies.
-Elevated expression of specific GST isoenzymes—most notably GST-π—has been associated with a poorer prognosis in several cancer types. This is often linked to resistance to chemo- or radiotherapy, as higher GST activity can lead to more efficient detoxification of these agents, reducing their cytotoxic effects.
-In contrast, reduced GST expression in some contexts might indicate a less robust detoxification system, which can correlate with increased sensitivity to oxidative stress and possibly a less aggressive tumor phenotype.
Scientific Papers found: Click to Expand⟱
2660- AL,    Allicin: A review of its important pharmacological activities
- Review, AD, NA - Review, Var, NA - Review, Park, NA - Review, Stroke, NA
*Inflam↓, AntiCan↑, *antiOx↑, *cardioP↑, *hepatoP↑, *BBB↑, *Half-Life↝, *H2S↑, *BP↓, *neuroP↑, *cognitive↑, *neuroP↑, *ROS↓, *GutMicro↑, *LDH↓, *ROS↓, *lipid-P↓, *antiOx↑, *other↑, *PI3K↓, *Akt↓, *NF-kB↓, *NO↓, *iNOS↓, *PGE2↓, *COX2↓, *IL6↓, *TNF-α↓, *MPO↓, *eff↑, *NRF2↑, *Keap1↓, *TBARS↓, *creat↓, *LDH↓, *AST↓, *ALAT↓, *MDA↓, *SOD↑, *GSH↑, *GSTs↑, *memory↑, chemoP↑, IL8↓, Cyt‑c↑, Casp3↑, Casp8↑, Casp9↑, Casp12↑, p38↑, Fas↑, P53↑, P21↑, CHK1↓, CycB/CCNB1↓, GSH↓, ROS↑, TumCCA↑, Hif1a↓, Bcl-2↓, VEGF↓, TumCMig↓, STAT3↓, VEGFR2↓, p‑FAK↓,
3269- ALA,    Sulfur-containing therapeutics in the treatment of Alzheimer’s disease
- NA, AD, NA
*AChE↓, *GlucoseCon↑, *ACC↑, *GSH↑, *Aβ↓, *Catalase↑, *GSR↑, *GSTs↑, *NADPH↑, *NQO1↑, *iNOS↓, *NF-kB↓, *lipid-P↓, *BBB↑, *memory↑, *cognitive↑, *antiOx↑, *Inflam↓,
3676- Ash,    Effect of Withania somnifera (Ashwagandha) root extract on amelioration of oxidative stress and autoantibodies production in collagen-induced arthritic rats
- in-vivo, Arthritis, NA
*CRP↓, *ROS↓, *lipid-P↓, *GSTs↓, *GSH↑, *antiOx↑, *Inflam↓,
4303- Ash,    Ashwagandha (Withania somnifera)—Current Research on the Health-Promoting Activities: A Narrative Review
- Review, AD, NA
*neuroP↑, *Sleep↑, *Inflam↓, *cardioP↑, *cognitive↑, *Aβ↓, *TNF-α↓, *IL1β↓, *IL6↓, *MCP1↓, *lipid-P↓, *tau↓, *ROS↓, *BBB↑, *AChE↓, *GSH↑, *GSTs↑, *GSR↑, *GPx↑, *SOD↑, *Catalase↑, ChemoSen↑, *Strength↑,
2717- BetA,    Betulinic Acid Induces ROS-Dependent Apoptosis and S-Phase Arrest by Inhibiting the NF-κB Pathway in Human Multiple Myeloma
- in-vitro, Melanoma, U266 - in-vivo, Melanoma, NA - in-vitro, Melanoma, RPMI-8226
Apoptosis↑, TumCCA↑, MMP↓, ROS↑, eff↓, NF-kB↓, Cyt‑c↑, Casp3↑, Casp8↑, Casp9↑, cl‑PARP1↑, MDA↑, SOD↓, SOD2↓, GCLM↓, GSTA1↓, FTH1↓, GSTs↓, TumVol↓,
2784- CHr,    Chrysin targets aberrant molecular signatures and pathways in carcinogenesis (Review)
- Review, Var, NA
Apoptosis↑, TumCMig↓, *toxicity↝, ChemoSen↑, *BioAv↓, Dose↝, neuroP↑, *P450↓, *ROS↓, *HDL↑, *GSTs↑, *SOD↑, *Catalase↑, *MAPK↓, *NF-kB↓, *PTEN↑, *VEGF↑, ROS↑, MMP↓, Ca+2↑, selectivity↑, PCNA↓, Twist↓, EMT↓, CDKN1C↑, p‑STAT3↑, MMP2↓, MMP9↓, eff↑, cycD1/CCND1↓, hTERT/TERT↓, CLDN1↓, TumVol↓, OS↑, COX2↓, eff↑, CDK2↓, CDK4↓, selectivity↑, TumCCA↑, E-cadherin↑, HK2↓, HDAC↓,
2786- CHr,    Chemopreventive and therapeutic potential of chrysin in cancer: mechanistic perspectives
- Review, Var, NA
Apoptosis↑, TumCCA↑, angioG↓, TumCI↓, TumMeta↑, *toxicity↓, selectivity↑, chemoPv↑, *GSTs↑, *NADPH↑, *GSH↑, HDAC8↓, Hif1a↓, *ROS↓, *NF-kB↓, SCF↓, cl‑PARP↑, survivin↓, XIAP↓, Casp3↑, Casp9↑, GSH↓, ChemoSen↑, Fenton↑, P21↑, P53↑, cycD1/CCND1↓, CDK2↓, STAT3↓, VEGF↓, Akt↓, NRF2↓,
2819- CUR,  Chemo,    Curcumin as a hepatoprotective agent against chemotherapy-induced liver injury
- Review, Var, NA
*hepatoP↑, *Inflam↓, *antiOx↑, *lipid-P↓, *GSH↑, *SOD↑, *Catalase↑, *GPx↑, *GSTs↑, *ROS↓, *ALAT↓, *AST↓, *MDA↓, *NRF2↑, *COX2↑, *NF-kB↓, *ICAM-1↓, *MCP1↓, *HO-1↑, CXCc↓,
2272- dietMet,    Methionine restriction - Association with redox homeostasis and implications on aging and diseases
- Review, Nor, NA
*OS↑, *mt-ROS↓, *H2S↑, *FGF21↑, *cognitive↑, *GutMicro↑, *IGF-1↓, *mTOR↓, *GSH↑, *SOD↑, *MDA↓, *NRF2↑, *HO-1↑, *NQO1↑, *GLUT4↑, *Glycolysis↑, *HK2↑, *PFK↑, *PKM2↑, *GlucoseCon↑, *ATF4↑, *PPARα↑, GSH↓, GSTs↑, ROS↑, *neuroP↑,
1621- EA,    The multifaceted mechanisms of ellagic acid in the treatment of tumors: State-of-the-art
- Review, Var, NA
AntiCan↑, Apoptosis↑, TumCP↓, TumMeta↓, TumCI↓, TumAuto↑, VEGFR2↓, MAPK↓, PI3K↓, Akt↓, PD-1↓, NOTCH↓, PCNA↓, Ki-67↓, cycD1/CCND1↓, CDK2↑, CDK6↓, Bcl-2↓, cl‑PARP↑, BAX↑, Casp3↑, DR4↑, DR5↑, Snail↓, MMP2↓, MMP9↓, TGF-β↑, PKCδ↓, β-catenin/ZEB1↓, SIRT1↓, HO-1↓, ROS↑, CHOP↑, Cyt‑c↑, MMP↓, OCR↓, AMPK↑, Hif1a↓, NF-kB↓, E-cadherin↑, Vim↓, EMT↓, LC3II↑, CIP2A↓, GLUT1↓, PDH↝, MAD↓, LDH↓, GSTs↑, NOTCH↓, survivin↓, XIAP↓, ER Stress↑, ChemoSideEff↓, ChemoSen↑,
1617- EA,  CUR,    The inhibition of human glutathione S-transferases activity by plant polyphenolic compounds ellagic acid and curcumin
- in-vitro, Nor, NA
Dose∅, GSTs↓,
3222- EGCG,    Epigallocatechin gallate and mitochondria—A story of life and death
- Review, Nor, NA
*lipid-P↓, *SOD↑, *Catalase↑, GPx↑, *GR↑, *GSTs↑, *GSH↑, *SIRT1↑, *PGC1A↑, *other↑,
2845- FIS,    Fisetin: A bioactive phytochemical with potential for cancer prevention and pharmacotherapy
- Review, Var, NA
PI3K↓, Akt↓, mTOR↓, p38↓, *antiOx↑, *neuroP↑, Casp3↑, Bcl-2↓, Mcl-1↓, BAX↑, BIM↑, BAD↑, AMPK↑, ACC↑, DNAdam↑, MMP↓, eff↑, ROS↑, cl‑PARP↑, Cyt‑c↑, Diablo↑, P53↑, p65↓, Myc↓, HSP70/HSPA5↓, HSP27↓, COX2↓, Wnt↓, EGFR↓, NF-kB↓, TumCCA↑, CDK2↓, CDK4↓, cycD1/CCND1↓, cycA1/CCNA1↓, P21↑, MMP2↓, MMP9↓, TumMeta↓, MMP1↓, MMP3↓, MMP7↓, MET↓, N-cadherin↓, Vim↓, Snail↓, Fibronectin↓, E-cadherin↑, uPA↓, ChemoSen↑, EMT↓, Twist↓, Zeb1↓, cFos↓, cJun↓, EGF↓, angioG↓, VEGF↓, eNOS↓, *NRF2↑, HO-1↑, NRF2↓, GSTs↓, ATF4↓,
2852- FIS,    A comprehensive view on the fisetin impact on colorectal cancer in animal models: Focusing on cellular and molecular mechanisms
- Review, CRC, NA
Risk↓, P53↑, MDM2↓, COX2↓, Wnt↓, NF-kB↓, CDK2↓, CDK4↓, p‑RB1↓, cycE/CCNE↓, P21↑, NRF2↓, ROS↑, Casp8↑, Fas↑, TRAIL↑, DR5↑, MMP↓, Cyt‑c↑, selectivity↑, P450↝, GSTs↝, RadioS↑, Inflam↓, β-catenin/ZEB1↓, EGFR↓, TumCCA↑, ChemoSen↑,
2859- FIS,    The Natural Flavonoid Fisetin Inhibits Cellular Proliferation of Hepatic, Colorectal, and Pancreatic Cancer Cells through Modulation of Multiple Signaling Pathways
- in-vitro, Liver, HepG2 - NA, Colon, Caco-2
TumCG↓, other↝, Casp3↑, Casp7↑, PGE2↓, GSTs↓, Wnt↓, EGFR↓, NF-kB↓, COX2↓, P53↑, P21↑, P450↓,
2861- FIS,    The neuroprotective effects of fisetin, a natural flavonoid in neurodegenerative diseases: Focus on the role of oxidative stress
- Review, Nor, NA - Review, Stroke, NA - Review, Park, NA
*antiOx↑, *ROS↓, *neuroP↑, *NO↑, BioAv↝, *BBB↑, *toxicity↑, *eff↑, *GSH↑, *SOD↑, *Aβ↓, *12LOX↓, *COX2↓, *Catalase↑, *Inflam↓, *TNF-α↓, *IL6↑, *lipid-P↓, NF-kB↓, IL1β↓, NRF2↑, HO-1↑, GSTs↑, cognitive↑, *BDNF↑,
2862- FIS,    Fisetin averts oxidative stress in pancreatic tissues of streptozotocin-induced diabetic rat
- in-vivo, Diabetic, NA
*BG↓, *NF-kB↓, *IL1β↓, *NO↓, *Insulin↑, *SOD↑, *Catalase↑, *GPx↑, *GSTs↑,
2916- LT,    Antioxidative and Anticancer Potential of Luteolin: A Comprehensive Approach Against Wide Range of Human Malignancies
- Review, Var, NA - Review, AD, NA - Review, Park, NA
proCasp9↓, CDC2↓, CycB/CCNB1↓, Casp9↑, Casp3↑, Cyt‑c↑, cycA1/CCNA1↑, CDK2↓, APAF1↑, TumCCA↑, P53↑, BAX↑, VEGF↓, Bcl-2↓, Apoptosis↑, p‑Akt↓, p‑EGFR↓, p‑ERK↓, p‑STAT3↓, cardioP↑, Catalase↓, SOD↓, *BioAv↓, *antiOx↑, *ROS↓, *NO↓, *GSTs↑, *GSR↑, *SOD↑, *Catalase↑, *lipid-P↓, PI3K↓, Akt↓, CDK2↓, BNIP3↑, hTERT/TERT↓, DR5↑, Beclin-1↑, TNF-α↓, NF-kB↓, IL1↓, IL6↓, EMT↓, FAK↓, E-cadherin↑, MDM2↓, NOTCH↓, MAPK↑, Vim↓, N-cadherin↓, Snail↓, MMP2↓, Twist↓, MMP9↓, ROS↑, MMP↓, *AChE↓, *MMP↑, *Aβ↓, *neuroP↑, Trx1↑, ROS↓, *NRF2↑, NRF2↓, *BBB↑, ChemoSen↑, GutMicro↑,
2919- LT,    Luteolin as a potential therapeutic candidate for lung cancer: Emerging preclinical evidence
- Review, Var, NA
RadioS↑, ChemoSen↑, chemoP↑, *lipid-P↓, *Catalase↑, *SOD↑, *GPx↑, *GSTs↑, *GSH↑, *TNF-α↓, *IL1β↓, *Casp3↓, *IL10↑, NRF2↓, HO-1↓, NQO1↓, GSH↓, MET↓, p‑MET↓, p‑Akt↓, HGF/c-Met↓, NF-kB↓, Bcl-2↓, SOD2↓, Casp8↑, Casp3↑, PARP↑, MAPK↓, NLRP3↓, ASC↓, Casp1↓, IL6↓, IKKα↓, p‑p65↓, p‑p38↑, MMP2↓, ICAM-1↓, EGFR↑, p‑PI3K↓, E-cadherin↓, ZO-1↑, N-cadherin↓, CLDN1↓, β-catenin/ZEB1↓, Snail↓, Vim↑, ITGB1↓, FAK↓, p‑Src↓, Rac1↓, Cdc42↓, Rho↓, PCNA↓, Tyro3↓, AXL↓, CEA↓, NSE↓, SOD↓, Catalase↓, GPx↓, GSR↓, GSTs↓, GSH↓, VitE↓, VitC↓, CYP1A1↓, cFos↑, AR↓, AIF↑, p‑STAT6↓, p‑MDM2↓, NOTCH1↓, VEGF↓, H3↓, H4↓, HDAC↓, SIRT1↓, ROS↑, DR5↑, Cyt‑c↑, p‑JNK↑, PTEN↓, mTOR↓, CD34↓, FasL↑, Fas↑, XIAP↓, p‑eIF2α↑, CHOP↑, LC3II↑, PD-1↓, STAT3↓, IL2↑, EMT↓, cachexia↓, BioAv↑, *Half-Life↝, *eff↑,
2922- LT,    Combination of transcriptomic and proteomic approaches helps unravel the mechanisms of luteolin in inducing liver cancer cell death via targeting AKT1 and SRC
- in-vitro, Liver, HUH7
Half-Life↝, TumCCA↑, AKT1↓, ATF2↓, NF-kB↓, GSK‐3β↓, cMyc↓, GSTs↓, TrxR1↓, ROS↑,
3264- Lyco,    Pharmacological potentials of lycopene against aging and aging‐related disorders: A review
- Review, Var, NA - Review, AD, NA - Review, Stroke, NA
*antiOx↑, *ROS↓, *SOD↑, *Catalase↑, *GSH↑, *GSTs↑, *MDA↓, *lipid-P↓, *NRF2↑, *HO-1↑, *iNOS↓, *NO↓, *TAC↑, *NOX4↓, *Inflam↓, *IL1↓, *IL6↓, *IL8↓, *IL1β↓, *TNF-α↓, *TLR2↓, *TLR4↓, *VCAM-1↓, *ICAM-1↓, *STAT3↓, *NF-kB↓, *ERK↓, *BP↓, ROS↓, PGE2↓, cardioP↑, *neuroP↑, *creat↓, *RenoP↑, *CRM↑,
3528- Lyco,    The Importance of Antioxidant Activity for the Health-Promoting Effect of Lycopene
- Review, Nor, NA - Review, AD, NA - Review, Park, NA
*antiOx↑, *ROS↓, *BioAv↝, *Half-Life↑, *BioAv↓, *BioAv↑, *cardioP↑, *neuroP↑, *H2O2↓, *VitC↑, *VitE↑, *GPx↑, *GSH↑, *MPO↓, *GSTs↓, *SOD↑, *NF-kB↓, *IL1β↓, *IL6↓, *IL10↑, *MAPK↓, *Akt↓, *COX2↓, *TNF-α↓, *TGF-β1↑, *NO↓, *GSR↑, *NRF2↑, *HO-1↑, *TAC↑, *Inflam↓, *BBB↑, *neuroP↑, *memory↑,
4797- Lyco,    A mechanistic updated overview on lycopene as potential anticancer agent
- Review, Var, NA
AntiCan↑, antiOx↓, Apoptosis↓, TumCP↓, TumCCA↑, Risk↓, ROS↓, SOD↑, Catalase↑, GSTs↑, ARE↑, NRF2↑, cycD1/CCND1↓, cycE/CCNE↑, CDK2↑, p27↑, BAX↑, Bcl-2↓, P53↑, ChemoSen↑,
4794- Lyco,    Anticancer Effect of Lycopene in Gastric Carcinogenesis
- Review, GC, NA
*AntiCan↑, *ROS↓, *GSH↑, *GPx↑, *GSTs↑, TumCG↓, Apoptosis↑, ERK↓, Bcl-2↓, BAX↑, Cyt‑c↑, TumCCA↑, *DNAdam↓,
3844- Moringa,    Review of the Safety and Efficacy of Moringa oleifera
- Review, NA, NA
*antiOx↑, *RenoP↑, *hepatoP↑, *radioP↑, *eff↑, *toxicity↓, *ROS↓, *lipid-P↓, *DNAdam↓, *Catalase↑, *SOD↑, *GPx↑, *GSR↑, *GSTs↑, *AST↓, *ALAT↓, *ALP↓, *Bil↓,
3595- PI,    Black pepper and health claims: a comprehensive treatise
- Review, Var, NA - Review, AD, NA
*antiOx↑, *ROS↓, *chemoP↑, TumCG↓, *cognitive↑, *MMPs↓, *PGE2↓, *AP-1↓, *5LO↓, *COX1↓, *other↑, *other↑, *other↑, *SOD↑, *Catalase↑, *GSTs↑, *GSR↑, *other↑, *Weight↓, *BioEnh↑, *BioAv↑, *eff↑, *CYP3A2↓, *neuroP↑, *BP↓, *other↑,
3596- PI,    Antioxidant efficacy of black pepper (Piper nigrum L.) and piperine in rats with high fat diet induced oxidative stress
- in-vivo, Nor, NA
*TBARS↑, *SOD↑, *Catalase↑, *GSTs↑, *GPx↑, *GSH↑, *ROS↓,
2942- PL,    Piperlongumine increases sensitivity of colorectal cancer cells to radiation: Involvement of ROS production via dual inhibition of glutathione and thioredoxin systems
- in-vitro, CRC, CT26 - in-vitro, CRC, DLD1 - in-vivo, CRC, CT26
ROS↑, GSH↓, TrxR↓, RadioS↑, DNAdam↑, TumCCA↑, mitResp↓, GSTs↓, OS↑,
3079- RES,    Therapeutic role of resveratrol against hepatocellular carcinoma: A review on its molecular mechanisms of action
- Review, Var, NA
angioG↓, TumMeta↓, ChemoSen↑, NADPH↑, SIRT1↑, NF-kB↓, NLRP3↓, Dose↝, COX2↓, MMP9↓, PGE2↓, TIMP1↑, TIMP2↑, Sp1/3/4↓, p‑JNK↓, uPAR↓, ROS↓, CXCR4↓, IL6↓, Gli1↓, *ROS↓, *GSTs↑, *SOD↑, *Catalase↑, *GPx↑, *lipid-P↓, *GSH↑, eff↑, eff↑, eff↑,
3001- RosA,    Therapeutic Potential of Rosmarinic Acid: A Comprehensive Review
- Review, Var, NA
TumCP↓, Apoptosis↑, TumMeta↓, Inflam↓, *antiOx↑, *AntiAge↑, *ROS↓, BioAv↑, Dose↝, NRF2↑, P-gp↑, ATP↑, MMPs↓, cl‑PARP↓, Hif1a↓, GlucoseCon↓, lactateProd↓, Warburg↓, TNF-α↓, COX2↓, IL6↓, HDAC2↓, GSH↑, ROS↓, ChemoSen↑, *BG↓, *IL1β↓, *TNF-α↓, *IL6↓, *p‑JNK↓, *p38↓, *Catalase↑, *SOD↑, *GSTs↑, *VitC↑, *VitE↑, *GSH↑, *GutMicro↑, *cardioP↑, *ROS↓, *MMP↓, *lipid-P↓, *NRF2↑, *hepatoP↑, *neuroP↑, *P450↑, *HO-1↑, *AntiAge↑, *motorD↓,
4735- Se,    Selenium triggers Nrf2-AMPK crosstalk to alleviate cadmium-induced autophagy in rabbit cerebrum
- in-vivo, Nor, NA
*MDA↓, *H2O2↓, *Catalase↑, *SOD↑, *GSTs↑, *GSH↑, *NRF2↓, *ATG3↓, *AMPK↓, *ROS↓,
4190- Sesame,    Sesame Seeds: A Nutrient-Rich Superfood
- Review, NA, NA
*antiOx↑, *LDL↓, *Aβ↓, *TNF-α↓, *SOD↑, *SIRT1↑, *Catalase↑, *GSH↑, *MDA↓, *GSTs↑, *IL4↑, *GPx↑, *COX2↓, *PGE2↓, *NO↓, CDK2↑, COX2↑, MMP9↑, ICAM-1↓, *BDNF↑, *PPARγ↑, *AChE↓, *Inflam↓, *HO-1↑, *NF-kB↓, *ROS↓,
4199- SFN,    Sulforaphane and Brain Health: From Pathways of Action to Effects on Specific Disorders
- Review, AD, NA - Review, Park, NA
*BBB↑, *BDNF↑, *neuroG↑, *NRF2↑, *HO-1↑, *Catalase↑, *SOD↑, *HSPs↑, *GSTs↑, *Trx↑, *GPx↑, *GSR↑, *GSH↑, *NQO1↑, *GutMicro↑, *Inflam↓, *neuroP↑,
1726- SFN,    Sulforaphane: A Broccoli Bioactive Phytocompound with Cancer Preventive Potential
- Review, Var, NA
Dose↝, eff↝, IL1β↓, IL6↓, IL12↓, TNF-α↓, COX2↓, CXCR4↓, MPO↓, HSP70/HSPA5↓, HSP90↓, VCAM-1↓, IKKα↓, NF-kB↓, HO-1↑, Casp3↑, Casp7↑, Casp8↑, Casp9↑, cl‑PARP↑, Cyt‑c↑, Diablo↑, CHOP↑, survivin↓, XIAP↓, p38↑, Fas↑, PUMA↑, VEGF↓, Hif1a↓, Twist↓, Zeb1↓, Vim↓, MMP2↓, MMP9↓, E-cadherin↑, N-cadherin↓, Snail↓, CD44↓, cycD1/CCND1↓, cycA1/CCNA1↓, CycB/CCNB1↓, cycE/CCNE↓, CDK4↓, CDK6↓, p50↓, P53↑, P21↑, GSH↑, SOD↑, GSTs↑, mTOR↓, Akt↓, PI3K↓, β-catenin/ZEB1↓, IGF-1↓, cMyc↓, CSCs↓,
3300- SIL,    Toward the definition of the mechanism of action of silymarin: activities related to cellular protection from toxic damage induced by chemotherapy
- Review, Var, NA
*ROS↓, *SOD↑, *hepatoP↑, *AST↓, *ALAT↓, *lipid-P↓, *GSH↑, *Catalase↑, *GSTs↑, *GSR↑, *TNF-α↓, *IFN-γ↓, *IL4↓, *IL2↓, *NF-kB↓, *IL10↑, *Inflam↓, COX2↓, Apoptosis↑, ChemoSen↑, PGE2↓, VEGF↓,
3293- SIL,    Silymarin (milk thistle extract) as a therapeutic agent in gastrointestinal cancer
- Review, Var, NA
hepatoP↑, TumMeta↓, Inflam↓, chemoP↑, radioP↑, Half-Life↝, *GSTs↑, p‑JNK↑, BAX↑, p‑p38↑, cl‑PARP↑, Bcl-2↓, p‑ERK↓, TumVol↓, eff↑, TumCCA↑, STAT3↓, Mcl-1↓, survivin↓, Bcl-xL↓, Casp3↑, Casp9↑, eff↑, CXCR4↓, Dose↝,
3313- SIL,    Silymarin attenuates post-weaning bisphenol A-induced renal injury by suppressing ferroptosis and amyloidosis through Kim-1/Nrf2/HO-1 signaling modulation in male Wistar rats
- in-vivo, NA, NA
*NRF2↑, *HO-1↑, *creat↓, *BUN↓, *RenoP↑, *MDA↓, *TNF-α↓, *IL1β↓, *Cyt‑c↓, *Casp3↓, *GSTs↓, *GSH↑, *GPx4↑, *SOD↑, *GSR↓, *Ferroptosis↓,
2205- SNP,    Potential protective efficacy of biogenic silver nanoparticles synthesised from earthworm extract in a septic mice model
- in-vivo, Nor, NA
*Dose↝, *eff↑, *RenoP↑, *antiOx↑, *MDA↓, *NO↓, *hepatoP↑, *toxicity↝, *GSH↑, *SOD↑, *GSTs↑, *Catalase↑,
3571- TQ,    The Role of Thymoquinone in Inflammatory Response in Chronic Diseases
- Review, Var, NA - Review, Stroke, NA
*BioAv↓, *BioAv↑, *Inflam↓, *antiOx↑, *ROS↓, *GSH↑, *GSTs↑, *MPO↓, *NF-kB↓, *COX2↓, *IL1β↓, *TNF-α↓, *IFN-γ↓, *IL6↓, *cardioP↑, *lipid-P↓, *TAC↑, *RenoP↑, Apoptosis↑, TumCCA↑, TumCP↓, TumCMig↓, angioG↓, TNF-α↓, NF-kB↓, ROS↑, EMT↓, *Aβ↓, *p‑tau↓, *BACE↓, *TLR2↓, *TLR4↓, *MyD88↓, *IRF3↓, *eff↑, eff↑, DNAdam↑, *iNOS↓,
3407- TQ,    Thymoquinone and its pharmacological perspective: A review
- Review, NA, NA
*antiOx↑, *ROS↓, *GSTs↑, *GSR↑, *GSH↑, *RenoP↑, *IL1β↓, *TNF-α↓, *MMP13↓, *COX2↓, *PGE2↓, *radioP↑, Twist↓, EMT↓, NF-kB↓, p‑PI3K↓, p‑Akt↓, p‑GSK‐3β↓, DNMT1↓, HDAC↓,
2088- TQ,    Nigella sativa L. and Its Bioactive Constituents as Hepatoprotectant: A Review
- Review, Nor, NA
*hepatoP↑, *lipid-P↓, *Thiols↑, *ROS↓, *Catalase↑, *SOD↑, *GSTs↑, *NF-kB↓, *COX2↓, *LOX1↓,
5024- TQ,    Thymoquinone: A Tie-Breaker in SARS-CoV2-Infected Cancer Patients?
- Review, Covid, NA
*NRF2↑, *NF-kB↓, *Inflam↓, *ROS↓, *HO-1↑, antiOx↑, GSH↑, GSTs↑, GSR↑, SOD1↑, Catalase↑, GPx↑, p62↓, Beclin-1↑, Sepsis↓, cardioP↑, hepatoP↑, neuroP↑,
2411- UA,    Ursolic acid in health and disease
- Review, Var, NA
Inflam↓, antiOx↑, NF-kB↓, Bcl-xL↓, Bcl-2↓, cycD1/CCND1↓, Ki-67↓, CD31↓, STAT3↓, EGFR↓, P53↑, P21↓, HK2↓, PKM2↓, ATP↓, lactateProd↓, p‑ERK↓, MMP↓, NO↑, ATM↑, Casp3↑, AMPK↑, JNK↑, FAO↑, FASN↓, *GSH↑, *SOD↑, *Catalase↑, *GPx↑, *GSTs↑, neuroP↑,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 43

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned ⓘ

chemoPv↑, 1,  

Redox & Oxidative Stress ⓘ

antiOx↓, 1,   antiOx↑, 2,   ARE↑, 1,   Catalase↓, 2,   Catalase↑, 2,   CYP1A1↓, 1,   Fenton↑, 1,   GCLM↓, 1,   GPx↓, 1,   GPx↑, 2,   GSH↓, 6,   GSH↑, 3,   GSR↓, 1,   GSR↑, 1,   GSTA1↓, 1,   GSTs↓, 7,   GSTs↑, 6,   GSTs↝, 1,   HO-1↓, 2,   HO-1↑, 3,   MAD↓, 1,   MDA↑, 1,   MPO↓, 1,   NQO1↓, 1,   NRF2↓, 5,   NRF2↑, 3,   ROS↓, 5,   ROS↑, 12,   SOD↓, 3,   SOD↑, 2,   SOD1↑, 1,   SOD2↓, 2,   Trx1↑, 1,   TrxR↓, 1,   TrxR1↓, 1,   VitC↓, 1,   VitE↓, 1,  

Metal & Cofactor Biology ⓘ

FTH1↓, 1,  

Mitochondria & Bioenergetics ⓘ

AIF↑, 1,   ATP↓, 1,   ATP↑, 1,   CDC2↓, 1,   EGF↓, 1,   mitResp↓, 1,   MMP↓, 7,   OCR↓, 1,   XIAP↓, 4,  

Core Metabolism/Glycolysis ⓘ

ACC↑, 1,   AKT1↓, 1,   AMPK↑, 3,   cMyc↓, 2,   FAO↑, 1,   FASN↓, 1,   GlucoseCon↓, 1,   HK2↓, 2,   lactateProd↓, 2,   LDH↓, 1,   NADPH↑, 1,   PDH↝, 1,   PKM2↓, 1,   SIRT1↓, 2,   SIRT1↑, 1,   Warburg↓, 1,  

Cell Death ⓘ

Akt↓, 5,   p‑Akt↓, 3,   APAF1↑, 1,   Apoptosis↓, 1,   Apoptosis↑, 9,   ATF2↓, 1,   BAD↑, 1,   BAX↑, 6,   Bcl-2↓, 9,   Bcl-xL↓, 2,   BIM↑, 1,   Casp1↓, 1,   Casp12↑, 1,   Casp3↑, 11,   Casp7↑, 2,   Casp8↑, 5,   Casp9↑, 6,   proCasp9↓, 1,   Cyt‑c↑, 9,   Diablo↑, 2,   DR4↑, 1,   DR5↑, 4,   Fas↑, 4,   FasL↑, 1,   HGF/c-Met↓, 1,   hTERT/TERT↓, 2,   JNK↑, 1,   p‑JNK↓, 1,   p‑JNK↑, 2,   MAPK↓, 2,   MAPK↑, 1,   Mcl-1↓, 2,   MDM2↓, 2,   p‑MDM2↓, 1,   Myc↓, 1,   p27↑, 1,   p38↓, 1,   p38↑, 2,   p‑p38↑, 2,   PUMA↑, 1,   survivin↓, 4,   TRAIL↑, 1,  

Kinase & Signal Transduction ⓘ

Sp1/3/4↓, 1,  

Transcription & Epigenetics ⓘ

cJun↓, 1,   H3↓, 1,   H4↓, 1,   other↝, 1,  

Protein Folding & ER Stress ⓘ

CHOP↑, 3,   p‑eIF2α↑, 1,   ER Stress↑, 1,   HSP27↓, 1,   HSP70/HSPA5↓, 2,   HSP90↓, 1,  

Autophagy & Lysosomes ⓘ

Beclin-1↑, 2,   BNIP3↑, 1,   LC3II↑, 2,   p62↓, 1,   TumAuto↑, 1,  

DNA Damage & Repair ⓘ

ATM↑, 1,   CHK1↓, 1,   DNAdam↑, 3,   DNMT1↓, 1,   P53↑, 9,   PARP↑, 1,   cl‑PARP↓, 1,   cl‑PARP↑, 5,   cl‑PARP1↑, 1,   PCNA↓, 3,  

Cell Cycle & Senescence ⓘ

CDK2↓, 6,   CDK2↑, 3,   CDK4↓, 4,   cycA1/CCNA1↓, 2,   cycA1/CCNA1↑, 1,   CycB/CCNB1↓, 3,   cycD1/CCND1↓, 7,   cycE/CCNE↓, 2,   cycE/CCNE↑, 1,   P21↓, 1,   P21↑, 6,   p‑RB1↓, 1,   TumCCA↑, 13,  

Proliferation, Differentiation & Cell State ⓘ

CD34↓, 1,   CD44↓, 1,   cFos↓, 1,   cFos↑, 1,   CIP2A↓, 1,   CSCs↓, 1,   EMT↓, 7,   ERK↓, 1,   p‑ERK↓, 3,   Gli1↓, 1,   GSK‐3β↓, 1,   p‑GSK‐3β↓, 1,   HDAC↓, 3,   HDAC2↓, 1,   HDAC8↓, 1,   IGF-1↓, 1,   mTOR↓, 3,   NOTCH↓, 3,   NOTCH1↓, 1,   PI3K↓, 4,   p‑PI3K↓, 2,   PTEN↓, 1,   SCF↓, 1,   p‑Src↓, 1,   STAT3↓, 5,   p‑STAT3↓, 1,   p‑STAT3↑, 1,   p‑STAT6↓, 1,   TumCG↓, 3,   Wnt↓, 3,  

Migration ⓘ

AXL↓, 1,   Ca+2↑, 1,   CD31↓, 1,   Cdc42↓, 1,   CDKN1C↑, 1,   CEA↓, 1,   CLDN1↓, 2,   E-cadherin↓, 1,   E-cadherin↑, 5,   FAK↓, 2,   p‑FAK↓, 1,   Fibronectin↓, 1,   ITGB1↓, 1,   Ki-67↓, 2,   MET↓, 2,   p‑MET↓, 1,   MMP1↓, 1,   MMP2↓, 6,   MMP3↓, 1,   MMP7↓, 1,   MMP9↓, 6,   MMP9↑, 1,   MMPs↓, 1,   N-cadherin↓, 4,   PKCδ↓, 1,   Rac1↓, 1,   Rho↓, 1,   Snail↓, 5,   TGF-β↑, 1,   TIMP1↑, 1,   TIMP2↑, 1,   TumCI↓, 2,   TumCMig↓, 3,   TumCP↓, 4,   TumMeta↓, 5,   TumMeta↑, 1,   Twist↓, 5,   Tyro3↓, 1,   uPA↓, 1,   uPAR↓, 1,   VCAM-1↓, 1,   Vim↓, 4,   Vim↑, 1,   Zeb1↓, 2,   ZO-1↑, 1,   β-catenin/ZEB1↓, 4,  

Angiogenesis & Vasculature ⓘ

angioG↓, 4,   ATF4↓, 1,   EGFR↓, 4,   EGFR↑, 1,   p‑EGFR↓, 1,   eNOS↓, 1,   Hif1a↓, 5,   NO↑, 1,   VEGF↓, 7,   VEGFR2↓, 2,  

Barriers & Transport ⓘ

GLUT1↓, 1,   P-gp↑, 1,  

Immune & Inflammatory Signaling ⓘ

ASC↓, 1,   COX2↓, 8,   COX2↑, 1,   CXCc↓, 1,   CXCR4↓, 3,   ICAM-1↓, 2,   IKKα↓, 2,   IL1↓, 1,   IL12↓, 1,   IL1β↓, 2,   IL2↑, 1,   IL6↓, 5,   IL8↓, 1,   Inflam↓, 4,   NF-kB↓, 14,   p50↓, 1,   p65↓, 1,   p‑p65↓, 1,   PD-1↓, 2,   PGE2↓, 4,   TNF-α↓, 4,  

Protein Aggregation ⓘ

NLRP3↓, 2,  

Hormonal & Nuclear Receptors ⓘ

AR↓, 1,   CDK6↓, 2,  

Drug Metabolism & Resistance ⓘ

BioAv↑, 2,   BioAv↝, 1,   ChemoSen↑, 12,   Dose↝, 5,   Dose∅, 1,   eff↓, 1,   eff↑, 9,   eff↝, 1,   Half-Life↝, 2,   P450↓, 1,   P450↝, 1,   RadioS↑, 3,   selectivity↑, 4,  

Clinical Biomarkers ⓘ

AR↓, 1,   CEA↓, 1,   EGFR↓, 4,   EGFR↑, 1,   p‑EGFR↓, 1,   GutMicro↑, 1,   hTERT/TERT↓, 2,   IL6↓, 5,   Ki-67↓, 2,   LDH↓, 1,   Myc↓, 1,   NSE↓, 1,  

Functional Outcomes ⓘ

AntiCan↑, 3,   cachexia↓, 1,   cardioP↑, 3,   chemoP↑, 3,   ChemoSideEff↓, 1,   cognitive↑, 1,   hepatoP↑, 2,   neuroP↑, 3,   OS↑, 2,   radioP↑, 1,   Risk↓, 2,   TumVol↓, 3,  

Infection & Microbiome ⓘ

Sepsis↓, 1,  
Total Targets: 295

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 17,   Bil↓, 1,   Catalase↑, 22,   Ferroptosis↓, 1,   GPx↑, 12,   GPx4↑, 1,   GSH↑, 25,   GSR↓, 1,   GSR↑, 9,   GSTs↓, 3,   GSTs↑, 27,   H2O2↓, 2,   HDL↑, 1,   HO-1↑, 9,   Keap1↓, 1,   lipid-P↓, 16,   MDA↓, 8,   MPO↓, 3,   NOX4↓, 1,   NQO1↑, 3,   NRF2↓, 1,   NRF2↑, 11,   ROS↓, 25,   mt-ROS↓, 1,   SOD↑, 25,   TAC↑, 3,   TBARS↓, 1,   TBARS↑, 1,   Thiols↑, 1,   Trx↑, 1,   VitC↑, 2,   VitE↑, 2,  

Mitochondria & Bioenergetics ⓘ

Insulin↑, 1,   MMP↓, 1,   MMP↑, 1,  

Core Metabolism/Glycolysis ⓘ

12LOX↓, 1,   ACC↑, 1,   ALAT↓, 4,   AMPK↓, 1,   BUN↓, 1,   CRM↑, 1,   CYP3A2↓, 1,   FGF21↑, 1,   GlucoseCon↑, 2,   Glycolysis↑, 1,   H2S↑, 2,   HK2↑, 1,   LDH↓, 2,   LDL↓, 1,   NADPH↑, 2,   PFK↑, 1,   PGC1A↑, 1,   PKM2↑, 1,   PPARα↑, 1,   PPARγ↑, 1,   SIRT1↑, 2,  

Cell Death ⓘ

Akt↓, 2,   Casp3↓, 2,   Cyt‑c↓, 1,   Ferroptosis↓, 1,   iNOS↓, 4,   p‑JNK↓, 1,   MAPK↓, 2,   p38↓, 1,  

Transcription & Epigenetics ⓘ

other↑, 7,  

Protein Folding & ER Stress ⓘ

HSPs↑, 1,  

Autophagy & Lysosomes ⓘ

ATG3↓, 1,  

DNA Damage & Repair ⓘ

DNAdam↓, 2,  

Proliferation, Differentiation & Cell State ⓘ

ERK↓, 1,   IGF-1↓, 1,   mTOR↓, 1,   neuroG↑, 1,   PI3K↓, 1,   PTEN↑, 1,   STAT3↓, 1,  

Migration ⓘ

5LO↓, 1,   AP-1↓, 1,   MMP13↓, 1,   MMPs↓, 1,   TGF-β1↑, 1,   VCAM-1↓, 1,  

Angiogenesis & Vasculature ⓘ

ATF4↑, 1,   LOX1↓, 1,   NO↓, 7,   NO↑, 1,   VEGF↑, 1,  

Barriers & Transport ⓘ

BBB↑, 7,   GLUT4↑, 1,  

Immune & Inflammatory Signaling ⓘ

COX1↓, 1,   COX2↓, 7,   COX2↑, 1,   CRP↓, 1,   ICAM-1↓, 2,   IFN-γ↓, 2,   IL1↓, 1,   IL10↑, 3,   IL1β↓, 9,   IL2↓, 1,   IL4↓, 1,   IL4↑, 1,   IL6↓, 6,   IL6↑, 1,   IL8↓, 1,   Inflam↓, 13,   MCP1↓, 2,   MyD88↓, 1,   NF-kB↓, 13,   PGE2↓, 4,   TLR2↓, 2,   TLR4↓, 2,   TNF-α↓, 12,  

Synaptic & Neurotransmission ⓘ

AChE↓, 4,   BDNF↑, 3,   tau↓, 1,   p‑tau↓, 1,  

Protein Aggregation ⓘ

Aβ↓, 6,   BACE↓, 1,  

Hormonal & Nuclear Receptors ⓘ

GR↑, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 4,   BioAv↑, 3,   BioAv↝, 1,   BioEnh↑, 1,   Dose↝, 1,   eff↑, 7,   Half-Life↑, 1,   Half-Life↝, 2,   P450↓, 1,   P450↑, 1,  

Clinical Biomarkers ⓘ

ALAT↓, 4,   ALP↓, 1,   AST↓, 4,   BG↓, 2,   Bil↓, 1,   BP↓, 3,   creat↓, 3,   CRP↓, 1,   GutMicro↑, 4,   IL6↓, 6,   IL6↑, 1,   LDH↓, 2,  

Functional Outcomes ⓘ

AntiAge↑, 2,   AntiCan↑, 1,   cardioP↑, 5,   chemoP↑, 1,   cognitive↑, 5,   hepatoP↑, 7,   memory↑, 3,   motorD↓, 1,   neuroP↑, 13,   OS↑, 1,   radioP↑, 2,   RenoP↑, 6,   Sleep↑, 1,   Strength↑, 1,   toxicity↓, 2,   toxicity↑, 1,   toxicity↝, 2,   Weight↓, 1,  

Infection & Microbiome ⓘ

IRF3↓, 1,  
Total Targets: 159

Scientific Paper Hit Count for: GSTs, Glutathione S-transferases
5 Fisetin
4 Lycopene
4 Thymoquinone
3 Luteolin
3 Silymarin (Milk Thistle) silibinin
2 Ashwagandha(Withaferin A)
2 Chrysin
2 Curcumin
2 Ellagic acid
2 Piperine
2 Sulforaphane (mainly Broccoli)
1 Allicin (mainly Garlic)
1 Alpha-Lipoic-Acid
1 Betulinic acid
1 Chemotherapy
1 diet Methionine-Restricted Diet
1 EGCG (Epigallocatechin Gallate)
1 Moringa oleifera
1 Piperlongumine
1 Resveratrol
1 Rosmarinic acid
1 Selenium
1 Sesame seeds and Oil
1 Silver-NanoParticles
1 Ursolic acid
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1153  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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