Database Query Results : , , tyrosinase

tyrosinase, tyrosinase: Click to Expand ⟱
Source:
Type:
Tyrosinase expression has been evaluated in various cancers—primarily melanoma—and its association with prognosis.
Tyrosinase and Cancer — Melanocytic Lineage Enzyme, Differentiation Marker, and Selective Target
Melanin Synthesis, Lineage Marker, and Therapeutic Handle

– Tyrosinase is normally expressed in melanocytes and is generally maintained in melanomas.
– Elevated tyrosinase expression in blood (detectable tyrosinase mRNA) has been correlated with advanced disease stage and the presence of micrometastases.
Direction of Regulation in Cancer
-Context-specific, but most informative in melanoma:
-Upregulated in differentiated melanocytic tumors
-Downregulated or lost in dedifferentiated, invasive, therapy-resistant melanoma states

Thus, tyrosinase is best read as a lineage/differentiation marker, not a universal oncogenic driver.


Scientific Papers found: Click to Expand⟱
1656- FA,    Ferulic Acid: A Natural Phenol That Inhibits Neoplastic Events through Modulation of Oncogenic Signaling
- Review, Var, NA
tyrosinase↓, CK2↓, TumCP↓, TumCMig↓, FGF↓, FGFR1↓, PI3K↓, Akt↓, VEGF↓, FGFR1↓, FGFR2↓, PDGF↓, ALAT↓, AST↓, TumCCA↑, CDK2↓, CDK4↓, CDK6↓, BAX↓, Bcl-2↓, MMP2↓, MMP9↓, P53↑, PARP↑, PUMA↑, NOXA↑, Casp3↑, Casp9↑, TIMP1↑, lipid-P↑, mtDam↑, EMT↓, Vim↓, E-cadherin↓, p‑STAT3↓, COX2↓, CDC25↓, RadioS↑, ROS↑, DNAdam↑, γH2AX↑, PTEN↑, LC3II↓, Beclin-1↓, SOD↓, Catalase↓, GPx↓, Fas↑, *BioAv↓, cMyc↓, Beclin-1↑, LC3‑Ⅱ/LC3‑Ⅰ↓,
4858- Uro,    The Metabolite Urolithin-A Ameliorates Oxidative Stress in Neuro-2a Cells, Becoming a Potential Neuroprotective Agent
- in-vitro, Nor, NA
*ROS?, *neuroP↑, *lipid-P↓, *Catalase↑, *SOD↑, *GPx↑, *GSR↑, *monoA↓, *tyrosinase↓,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

Catalase↓, 1,   GPx↓, 1,   lipid-P↑, 1,   ROS↑, 1,   SOD↓, 1,  

Mitochondria & Bioenergetics ⓘ

CDC25↓, 1,   FGFR1↓, 2,   mtDam↑, 1,  

Core Metabolism/Glycolysis ⓘ

ALAT↓, 1,   cMyc↓, 1,  

Cell Death ⓘ

Akt↓, 1,   BAX↓, 1,   Bcl-2↓, 1,   Casp3↑, 1,   Casp9↑, 1,   CK2↓, 1,   Fas↑, 1,   NOXA↑, 1,   PUMA↑, 1,  

Autophagy & Lysosomes ⓘ

Beclin-1↓, 1,   Beclin-1↑, 1,   LC3‑Ⅱ/LC3‑Ⅰ↓, 1,   LC3II↓, 1,  

DNA Damage & Repair ⓘ

DNAdam↑, 1,   P53↑, 1,   PARP↑, 1,   γH2AX↑, 1,  

Cell Cycle & Senescence ⓘ

CDK2↓, 1,   CDK4↓, 1,   TumCCA↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

EMT↓, 1,   FGF↓, 1,   FGFR2↓, 1,   PI3K↓, 1,   PTEN↑, 1,   p‑STAT3↓, 1,   tyrosinase↓, 1,  

Migration ⓘ

E-cadherin↓, 1,   MMP2↓, 1,   MMP9↓, 1,   PDGF↓, 1,   TIMP1↑, 1,   TumCMig↓, 1,   TumCP↓, 1,   Vim↓, 1,  

Angiogenesis & Vasculature ⓘ

VEGF↓, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 1,  

Hormonal & Nuclear Receptors ⓘ

CDK6↓, 1,  

Drug Metabolism & Resistance ⓘ

RadioS↑, 1,  

Clinical Biomarkers ⓘ

ALAT↓, 1,   AST↓, 1,  
Total Targets: 51

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

Catalase↑, 1,   GPx↑, 1,   GSR↑, 1,   lipid-P↓, 1,   ROS?, 1,   SOD↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

tyrosinase↓, 1,  

Synaptic & Neurotransmission ⓘ

monoA↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 1,  

Functional Outcomes ⓘ

neuroP↑, 1,  
Total Targets: 10

Scientific Paper Hit Count for: tyrosinase, tyrosinase
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1160  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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