Database Query Results : , , proline

proline, proline: Click to Expand ⟱
Source:
Type:
Proline, a non-essential amino acid, plays multiple roles in cellular function, including protein synthesis, energy metabolism, and redox balance.
– Proline is a key component in the structure of proteins (notably collagen) and influences protein folding due to its unique cyclic structure.
– Its availability is critical for extracellular matrix synthesis, which is important for tumor stroma remodeling and metastasis.

The effect of proline on the metabolism of tumor cells seems to be particularly important, where a significant increase in the concentration of this amino acid is observed in comparison with normal cells. The high concentration of intracellular proline is associated with an enhanced ability of tumor cells to metastasize.

– Proline can serve as a source of energy under metabolic stress.
– The enzyme proline dehydrogenase (PRODH) initiates proline catabolism, converting it into pyrroline-5-carboxylate (P5C) and influencing the mitochondrial redox state.
– This process is linked to the generation of reactive oxygen species (ROS), which may either signal adaptive responses or promote apoptosis depending on context.
– Proline metabolism is intertwined with cellular redox balance. PRODH activity can contribute to ROS production, potentially triggering stress responses in tumor cells.

– Upregulation of PRODH and the resultant ROS production can induce apoptosis in some contexts, acting as a tumor suppressive mechanism.
Scientific Papers found: Click to Expand⟱
1679- PBG,    Constituents of Propolis: Chrysin, Caffeic Acid, p-Coumaric Acid, and Ferulic Acid Induce PRODH/POX-Dependent Apoptosis in Human Tongue Squamous Cell Carcinoma Cell (CAL-27)
- in-vitro, SCC, CAL27
tumCV↓, P53↑, Casp9↑, Casp3↑, GSH↓, proline↓,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

GSH↓, 1,  

Cell Death ⓘ

Casp3↑, 1,   Casp9↑, 1,  

Transcription & Epigenetics ⓘ

tumCV↓, 1,  

DNA Damage & Repair ⓘ

P53↑, 1,  

Migration ⓘ

proline↓, 1,  
Total Targets: 6

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: proline, proline
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1165  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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