Database Query Results : , , Piezo1

Piezo1, Piezo1: Click to Expand ⟱
Source:
Type:
Piezo1 is a mechanosensitive ion channel that converts mechanical stimuli into electrochemical signals.

Piezo1 protein is a mechanosensitive ion channel that allows intracellular calcium influx in response to various mechanical signals such as static pressure, shear stress, and membrane stretch and further initiates downstream biological responses. It is critical in various physiological processes, including the development of vasculatures, regulation of red blood cell volume, and sensation of light touch. Piezo1 is also highly expressed in the bone, regulating the differentiation of mesenchymal stem cells and mediating calcium ion influx in osteocytes and osteoblasts.

In a number of cancer types (such as breast, colon, and prostate cancer), studies have found that Piezo1 is often upregulated.
An increase in Piezo1 expression can promote enhanced cell migration and invasive behavior, both of which are critical for cancer spread.
Scientific Papers found: Click to Expand⟱
1755- WBV,    Reduction of breast cancer extravasation via vibration activated osteocyte regulation
Dose∅, TumMeta↑, eff∅, Piezo1↑, COX2↑, RANKL↓, TumCG∅, tumCV∅, TumCI↓,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Transcription & Epigenetics ⓘ

tumCV∅, 1,  

Proliferation, Differentiation & Cell State ⓘ

Piezo1↑, 1,   TumCG∅, 1,  

Migration ⓘ

TumCI↓, 1,   TumMeta↑, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↑, 1,  

Hormonal & Nuclear Receptors ⓘ

RANKL↓, 1,  

Drug Metabolism & Resistance ⓘ

Dose∅, 1,   eff∅, 1,  
Total Targets: 9

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: Piezo1, Piezo1
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1182  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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