Database Query Results : , , RANKL

RANKL, Receptor Activator of Nuclear Factor κB Ligand: Click to Expand ⟱
Source:
Type:
RANKL (Receptor Activator of Nuclear Factor κB Ligand, formally known as TNFSF11)


-High expression of RANKL (or increased activity of the RANK pathway) has been linked to a higher tendency for bone metastasis, particularly in certain subtypes (e.g., estrogen receptor–negative cancers).
-Activation of this pathway may predict poor outcomes in specific settings, though the direct prognostic significance of RANKL levels still calls for additional clinical validation.
Scientific Papers found: Click to Expand⟱
1782- MEL,    Melatonin in Cancer Treatment: Current Knowledge and Future Opportunities
- Review, Var, NA
AntiCan↑, Apoptosis↑, TumCP↓, TumCG↑, TumMeta↑, ChemoSideEff↓, radioP↑, ChemoSen↑, *ROS↓, *SOD↑, *GSH↑, *GPx↑, *Catalase↑, Dose∅, VEGF↓, eff↑, Hif1a↓, GLUT1↑, GLUT3↑, CAIX↑, P21↑, p27↑, PTEN↑, Warburg↓, PI3K↓, Akt↓, NF-kB↓, cycD1/CCND1↓, CDK4↓, CycB/CCNB1↓, CDK4↓, MAPK↑, IGF-1R↓, STAT3↓, MMP9↓, MMP2↓, MMP13↓, E-cadherin↑, Vim↓, RANKL↓, JNK↑, Bcl-2↓, P53↑, Casp3↑, Casp9↑, BAX↑, DNArepair↑, COX2↓, IL6↓, IL8↓, NO↓, T-Cell↑, NK cell↑, Treg lymp↓, FOXP3↓, CD4+↑, TNF-α↑, Th1 response↑, BioAv↝, RadioS↑, OS↑,
1755- WBV,    Reduction of breast cancer extravasation via vibration activated osteocyte regulation
Dose∅, TumMeta↑, eff∅, Piezo1↑, COX2↑, RANKL↓, TumCG∅, tumCV∅, TumCI↓,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


Core Metabolism/Glycolysis ⓘ

CAIX↑, 1,   Warburg↓, 1,  

Cell Death ⓘ

Akt↓, 1,   Apoptosis↑, 1,   BAX↑, 1,   Bcl-2↓, 1,   Casp3↑, 1,   Casp9↑, 1,   JNK↑, 1,   MAPK↑, 1,   p27↑, 1,  

Transcription & Epigenetics ⓘ

tumCV∅, 1,  

DNA Damage & Repair ⓘ

DNArepair↑, 1,   P53↑, 1,  

Cell Cycle & Senescence ⓘ

CDK4↓, 2,   CycB/CCNB1↓, 1,   cycD1/CCND1↓, 1,   P21↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

IGF-1R↓, 1,   PI3K↓, 1,   Piezo1↑, 1,   PTEN↑, 1,   STAT3↓, 1,   TumCG↑, 1,   TumCG∅, 1,  

Migration ⓘ

E-cadherin↑, 1,   MMP13↓, 1,   MMP2↓, 1,   MMP9↓, 1,   Treg lymp↓, 1,   TumCI↓, 1,   TumCP↓, 1,   TumMeta↑, 2,   Vim↓, 1,  

Angiogenesis & Vasculature ⓘ

Hif1a↓, 1,   NO↓, 1,   VEGF↓, 1,  

Barriers & Transport ⓘ

GLUT1↑, 1,   GLUT3↑, 1,  

Immune & Inflammatory Signaling ⓘ

CD4+↑, 1,   COX2↓, 1,   COX2↑, 1,   FOXP3↓, 1,   IL6↓, 1,   IL8↓, 1,   NF-kB↓, 1,   NK cell↑, 1,   T-Cell↑, 1,   Th1 response↑, 1,   TNF-α↑, 1,  

Hormonal & Nuclear Receptors ⓘ

RANKL↓, 2,  

Drug Metabolism & Resistance ⓘ

BioAv↝, 1,   ChemoSen↑, 1,   Dose∅, 2,   eff↑, 1,   eff∅, 1,   RadioS↑, 1,  

Clinical Biomarkers ⓘ

IL6↓, 1,  

Functional Outcomes ⓘ

AntiCan↑, 1,   ChemoSideEff↓, 1,   OS↑, 1,   radioP↑, 1,  
Total Targets: 62

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

Catalase↑, 1,   GPx↑, 1,   GSH↑, 1,   ROS↓, 1,   SOD↑, 1,  
Total Targets: 5

Scientific Paper Hit Count for: RANKL, Receptor Activator of Nuclear Factor κB Ligand
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1183  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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