Database Query Results : , , SMCT1

SMCT1, SLC5A8: Click to Expand ⟱
Source:
Type:
SLC5A8 (also known as SMCT1) is a sodium-coupled monocarboxylate transporter.

- Many studies suggest that SLC5A8 functions as a tumor suppressor. In normal tissues, SLC5A8 contributes to the cellular uptake of short-chain fatty acids (SCFAs) like butyrate. Butyrate is known to have histone deacetylase inhibitor activity, which can modulate gene expression in a way that suppresses tumor growth.
-In cancer, loss or silencing of SLC5A8 is often observed. Epigenetic mechanisms such as DNA hypermethylation of the SLC5A8 promoter region are commonly cited as a reason for its downregulation.

SLC5A8 is commonly downregulated in a variety of cancers. Its loss, often due to promoter hypermethylation, correlates with poorer outcomes in several tumor types, suggesting a tumor suppressor role. While sustained expression of SLC5A8 appears to be protective and is associated with a better prognosis in some cancers, the field is still evolving.

Inhibitors of DNA methylation induce reactivation of SLC5A8.
procaine is a DNA-demethylating agent with growth-inhibitory effects in human cancer cells.
Scientific Papers found: Click to Expand⟱
1885- DCA,    Role of SLC5A8, a plasma membrane transporter and a tumor suppressor, in the antitumor activity of dichloroacetate
- in-vitro, CRC, HCT116 - in-vitro, CRC, SW-620 - in-vitro, CRC, HT-29
SMCT1∅, eff↓, eff↑, eff↑, PDKs↓, MMP↓, Glycolysis↓, mitResp↑, ROS↑, eff↑,
1886- Dicl,    Regulation of colonic epithelial butyrate transport: Focus on colorectal cancer
- Review, CRC, NA
SMCT1↑,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

ROS↑, 1,  

Mitochondria & Bioenergetics ⓘ

mitResp↑, 1,   MMP↓, 1,  

Core Metabolism/Glycolysis ⓘ

Glycolysis↓, 1,   PDKs↓, 1,  

Barriers & Transport ⓘ

SMCT1↑, 1,   SMCT1∅, 1,  

Drug Metabolism & Resistance ⓘ

eff↓, 1,   eff↑, 3,  
Total Targets: 9

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: SMCT1, SLC5A8
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1202  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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