Database Query Results : , , K17

K17, Keratin 17: Click to Expand ⟱
Source:
Type:
Keratin 17 (K17) is an intermediate filament protein that has emerged as more than just a structural component in epithelial cells.

-K17 is frequently upregulated in certain subtypes of breast, CC, SCC cancer, especially in triple-negative breast cancers (TNBC).
–Prognosis: High K17 expression has been correlated with aggressive tumor behavior, higher proliferation rates, and poorer overall survival. It is emerging as a marker for tumor aggressiveness in this context.
Scientific Papers found: Click to Expand⟱
1938- PL,    Piperlongumine regulates epigenetic modulation and alleviates psoriasis-like skin inflammation via inhibition of hyperproliferation and inflammation
- Study, PSA, NA - in-vivo, NA, NA
ROS↑, Apoptosis↑, MMP↓, TumCCA↑, DNAdam↑, STAT3↓, Akt↓, PCNA↓, Ki-67↓, cycD1/CCND1↓, Bcl-2↓, K17↓, HDAC↓, ROS↑, *IL1β↓, *IL6↓, *TNF-α↓, *IL17↓, *IL22↓,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

ROS↑, 2,  

Mitochondria & Bioenergetics ⓘ

MMP↓, 1,  

Cell Death ⓘ

Akt↓, 1,   Apoptosis↑, 1,   Bcl-2↓, 1,  

DNA Damage & Repair ⓘ

DNAdam↑, 1,   PCNA↓, 1,  

Cell Cycle & Senescence ⓘ

cycD1/CCND1↓, 1,   TumCCA↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

HDAC↓, 1,   STAT3↓, 1,  

Migration ⓘ

Ki-67↓, 1,  

Clinical Biomarkers ⓘ

Ki-67↓, 1,  

Functional Outcomes ⓘ

K17↓, 1,  
Total Targets: 14

Pathway results for Effect on Normal Cells:


Immune & Inflammatory Signaling ⓘ

IL17↓, 1,   IL1β↓, 1,   IL22↓, 1,   IL6↓, 1,   TNF-α↓, 1,  

Clinical Biomarkers ⓘ

IL6↓, 1,  
Total Targets: 6

Scientific Paper Hit Count for: K17, Keratin 17
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1211  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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