Database Query Results : , , Prx4

Prx4, Peroxiredoxin 4: Click to Expand ⟱
Source:
Type:
Peroxiredoxin 4 (PRDX4) is one of the members of the peroxiredoxin family of antioxidant enzymes. It plays a key role in reducing hydrogen peroxide and other peroxides, thereby contributing to the maintenance of the intracellular redox balance. In addition to its antioxidant function, PRDX4 is located in the endoplasmic reticulum (and can be secreted), which adds complexity to its role in cellular homeostasis, stress responses, and cancer biology.

– Several studies have reported that PRDX4 is overexpressed in various cancers, including lung, breast, prostate, and gastrointestinal cancers.
– In some cases, increased PRDX4 levels are thought to reflect a cellular adaptation to elevated oxidative stress in the tumor microenvironment.
– High PRDX4 expression has been observed to correlate with more aggressive tumor phenotypes in particular cancer types. This may be due to its role in protecting cancer cells from oxidative damage, thereby supporting cell survival and growth under stress conditions.
– In some studies, increased PRDX4 has been linked to enhanced tumor progression, metastasis, and resistance to therapy.
Scientific Papers found: Click to Expand⟱
1943- PL,    Piperlongumine treatment inactivates peroxiredoxin 4, exacerbates endoplasmic reticulum stress, and preferentially kills high-grade glioma cells
- in-vitro, GBM, NA - in-vivo, NA, NA
selectivity↑, ROS↑, selectivity↑, Prx4↓, *Prx4∅, ER Stress↑, CHOP↑, UPR↑,
2946- PL,    Piperlongumine, a potent anticancer phytotherapeutic: Perspectives on contemporary status and future possibilities as an anticancer agent
- Review, Var, NA
ROS↑, GSH↓, DNAdam↑, ChemoSen↑, RadioS↑, BioEnh↑, selectivity↑, BioAv↓, eff↑, p‑Akt↓, mTOR↓, GSK‐3β↓, β-catenin/ZEB1↓, HK2↓, Glycolysis↓, Cyt‑c↑, Casp9↑, Casp3↑, Casp7↑, cl‑PARP↑, TrxR↓, ER Stress↑, ATF4↝, CHOP↑, Prx4↑, NF-kB↓, cycD1/CCND1↓, CDK4↓, CDK6↓, p‑RB1↓, RAS↓, cMyc↓, TumCCA↑, selectivity↑, STAT3↓, NRF2↑, HO-1↑, PTEN↑, P-gp↓, MDR1↓, MRP1↓, survivin↓, Twist↓, AP-1↓, Sp1/3/4↓, STAT1↓, STAT6↓, SOX4↑, XBP-1↑, P21↑, eff↑, Inflam↓, COX2↓, IL6↓, MMP9↓, TumMeta↓, TumCI↓, ICAM-1↓, CXCR4↓, VEGF↓, angioG↓, Half-Life↝, BioAv↑,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

GSH↓, 1,   HO-1↑, 1,   NRF2↑, 1,   Prx4↓, 1,   Prx4↑, 1,   ROS↑, 2,   TrxR↓, 1,  

Core Metabolism/Glycolysis ⓘ

cMyc↓, 1,   Glycolysis↓, 1,   HK2↓, 1,  

Cell Death ⓘ

p‑Akt↓, 1,   Casp3↑, 1,   Casp7↑, 1,   Casp9↑, 1,   Cyt‑c↑, 1,   survivin↓, 1,  

Kinase & Signal Transduction ⓘ

Sp1/3/4↓, 1,  

Protein Folding & ER Stress ⓘ

CHOP↑, 2,   ER Stress↑, 2,   UPR↑, 1,   XBP-1↑, 1,  

DNA Damage & Repair ⓘ

DNAdam↑, 1,   cl‑PARP↑, 1,  

Cell Cycle & Senescence ⓘ

CDK4↓, 1,   cycD1/CCND1↓, 1,   P21↑, 1,   p‑RB1↓, 1,   TumCCA↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

GSK‐3β↓, 1,   mTOR↓, 1,   PTEN↑, 1,   RAS↓, 1,   STAT1↓, 1,   STAT3↓, 1,   STAT6↓, 1,  

Migration ⓘ

AP-1↓, 1,   MMP9↓, 1,   SOX4↑, 1,   TumCI↓, 1,   TumMeta↓, 1,   Twist↓, 1,   β-catenin/ZEB1↓, 1,  

Angiogenesis & Vasculature ⓘ

angioG↓, 1,   ATF4↝, 1,   VEGF↓, 1,  

Barriers & Transport ⓘ

P-gp↓, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 1,   CXCR4↓, 1,   ICAM-1↓, 1,   IL6↓, 1,   Inflam↓, 1,   NF-kB↓, 1,  

Hormonal & Nuclear Receptors ⓘ

CDK6↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 1,   BioAv↑, 1,   BioEnh↑, 1,   ChemoSen↑, 1,   eff↑, 2,   Half-Life↝, 1,   MDR1↓, 1,   MRP1↓, 1,   RadioS↑, 1,   selectivity↑, 4,  

Clinical Biomarkers ⓘ

IL6↓, 1,  
Total Targets: 64

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

Prx4∅, 1,  
Total Targets: 1

Scientific Paper Hit Count for: Prx4, Peroxiredoxin 4
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1213  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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