Database Query Results : , , p66Shc

p66Shc, p66Shc: Click to Expand ⟱
Source:
Type:
p66Shc is one of three isoforms encoded by the ShcA gene and is well known for its roles in oxidative stress response, apoptosis, and cellular metabolism.

• Some studies have revealed that altered p66Shc expression is associated with changes in oxidative stress signaling.
• Elevated p66Shc activity in certain contexts has been linked to enhanced reactive oxygen species (ROS) production, which may promote tumor progression.
• However, the exact relationship is complex; in some research, higher p66Shc levels have been associated with increased cancer cell apoptosis and a better prognosis, while in other studies a pro-oxidative environment may favor tumor aggressiveness.
Scientific Papers found: Click to Expand⟱
1956- GamB,    Gambogic Acid Inhibits Malignant Melanoma Cell Proliferation Through Mitochondrial p66shc/ROS-p53/Bax-Mediated Apoptosis
- in-vitro, Melanoma, A375
tumCV↓, Apoptosis↑, ROS↑, p66Shc↑,
3339- QC,    Quercetin suppresses ROS production and migration by specifically targeting Rac1 activation in gliomas
- in-vitro, GBM, C6 - in-vitro, GBM, IMR32
BBB↑, tumCV↓, TumCMig↓, Rac1↓, p66Shc↓, ROS↓,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

p66Shc↓, 1,   p66Shc↑, 1,   ROS↓, 1,   ROS↑, 1,  

Cell Death ⓘ

Apoptosis↑, 1,  

Transcription & Epigenetics ⓘ

tumCV↓, 2,  

Migration ⓘ

Rac1↓, 1,   TumCMig↓, 1,  

Barriers & Transport ⓘ

BBB↑, 1,  
Total Targets: 9

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: p66Shc, p66Shc
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1215  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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