Database Query Results : , , 6PGD

6PGD, 6-phosphogluconate dehydrogenase: Click to Expand ⟱
Source:
Type:
6PGD is a key enzyme in the oxidative branch of the pentose phosphate pathway (PPP), contributing to nucleotide biosynthesis and the production of NADPH. This activity is essential for maintaining redox homeostasis and supporting anabolic processes in rapidly proliferating cells.

-In several cancers, elevated 6PGD expression or activity is associated with aggressive tumor behavior and poorer prognosis.
Scientific Papers found: Click to Expand⟱
1963- GamB,    Gambogic acid exhibits promising anticancer activity by inhibiting the pentose phosphate pathway in lung cancer mouse model
- in-vitro, Lung, NA
ROS↑, 6PGD↓, PPP↓,
1964- GamB,    Gambogic acid suppresses the pentose phosphate pathway by covalently inhibiting 6PGD protein in cancer cells
- in-vitro, NA, NA
PPP↓, 6PGD↓,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

ROS↑, 1,  

Core Metabolism/Glycolysis ⓘ

6PGD↓, 2,   PPP↓, 2,  
Total Targets: 3

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: 6PGD, 6-phosphogluconate dehydrogenase
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1217  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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