Database Query Results : , , Mich

Mich, Michael addition reaction.: Click to Expand ⟱
Source:
Type:
The Michael addition reaction is a type of nucleophilic conjugate addition where a nucleophile attacks an α,β-unsaturated carbonyl compound (or, more generally, an electron-deficient alkene). This reaction is a cornerstone in organic synthesis, allowing the formation of carbon–carbon or carbon–heteroatom bonds under relatively mild conditions.

-In biological systems, proteins often contain cysteine residues with thiol (-SH) groups that can act as nucleophiles.

Some anticancer drug development strategies employ compounds that act as Michael acceptors. These drugs are designed to specifically form covalent bonds with cysteine residues on target proteins (such as enzymes or receptors involved in cancer cell survival). The irreversible binding can result in a prolonged inhibitory effect.

Nrf2 Pathway Activation: Certain natural compounds with Michael acceptor properties (such as curcumin or specific electrophilic phytochemicals) can activate the Nrf2 (nuclear factor erythroid 2–related factor 2) pathway.

-The modulation of proteins via Michael addition can indirectly affect the cellular redox state, influencing ROS levels.

Natural compounds known to exhibit Michael acceptor properties:
-Curcumin
-Sulforaphane
-Parthenolide
-Caffeic Acid Phenethyl Ester (CAPE)
-Withania somnifera (ashwagandha)
-Gambogic Acid
-Dimethyl Fumarate (DMF) (resembles natural fumaric acid)
Scientific Papers found: Click to Expand⟱
1973- GamB,    Gambogic acid deactivates cytosolic and mitochondrial thioredoxins by covalent binding to the functional domain
- in-vitro, Liver, SMMC-7721 cell
Apoptosis↑, ROS↑, Trx↓, Trx1↓, Trx2↓, Mich↑,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

Mich↑, 1,   ROS↑, 1,   Trx↓, 1,   Trx1↓, 1,   Trx2↓, 1,  

Cell Death ⓘ

Apoptosis↑, 1,  
Total Targets: 6

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: Mich, Michael addition reaction.
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1219  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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