Database Query Results : , , TrxR2

TrxR2, thioredoxin reductase-mitochondrial: Click to Expand ⟱
Source:
Type:
TrxR2 is a mitochondrial selenoprotein that reduces oxidized Trx2, thereby preserving a reduced environment within the mitochondria.
• By maintaining mitochondrial redox homeostasis, TrxR2 contributes to cell survival, protects against oxidative stress, and helps regulate apoptosis.
• Its activity is especially critical in rapidly proliferating cells, such as cancer cells, which often experience elevated levels of reactive oxygen species (ROS).

-In various cancers—such as breast, lung, and colorectal cancers—upregulation of TrxR2 has been linked to enhanced cell survival, resistance to oxidative stress, and, in some studies, poorer clinical outcomes.
Scientific Papers found: Click to Expand⟱
1984- Part,    Targeting Thioredoxin Reductase by Parthenolide Contributes to Inducing Apoptosis of HeLa Cells
- in-vitro, Cerv, HeLa
AntiCan↑, TrxR1↓, TrxR2↓, ROS↑, Apoptosis↑, eff↓, eff↑,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

ROS↑, 1,   TrxR1↓, 1,   TrxR2↓, 1,  

Cell Death ⓘ

Apoptosis↑, 1,  

Drug Metabolism & Resistance ⓘ

eff↓, 1,   eff↑, 1,  

Functional Outcomes ⓘ

AntiCan↑, 1,  
Total Targets: 7

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: TrxR2, thioredoxin reductase-mitochondrial
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1222  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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