Database Query Results : , , SLC25A1

SLC25A1, CIC: Click to Expand ⟱
Source:
Type:
SLC25A1 (also known as the mitochondrial citrate carrier, CIC) in cancer and its potential prognostic implications. SLC25A1 plays a central role in cellular metabolism by transporting citrate out of the mitochondria into the cytosol, where it can be used in lipid biosynthesis and energy production.

• SLC25A1 facilitates the transport of citrate from the mitochondria to the cytosol. Once in the cytosol, citrate can be converted into acetyl-CoA, serving as a substrate for lipid synthesis and histone acetylation.
• By linking mitochondrial metabolism with cytosolic biosynthetic pathways, SLC25A1 plays a key role in metabolic reprogramming—a hallmark of cancer.

-In various cancers, including breast, lung, and colorectal cancers, elevated SLC25A1 expression has been associated—with varying degrees of consistency—with metabolic reprogramming that supports tumor growth and survival. As such, high SLC25A1 levels are often considered a marker of aggressive disease and may correlate with poorer prognosis.
Scientific Papers found: Click to Expand⟱
1991- Part,    A novel SLC25A1 inhibitor, parthenolide, suppresses the growth and stemness of liver cancer stem cells with metabolic vulnerability
- in-vitro, Liver, HUH7
TumCCA↑, Apoptosis↑, CSCs↓, ROS↑, OXPHOS↓, MMP↓, SLC25A1↓, IDH2↓,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

OXPHOS↓, 1,   ROS↑, 1,  

Mitochondria & Bioenergetics ⓘ

MMP↓, 1,  

Core Metabolism/Glycolysis ⓘ

IDH2↓, 1,   SLC25A1↓, 1,  

Cell Death ⓘ

Apoptosis↑, 1,  

Cell Cycle & Senescence ⓘ

TumCCA↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

CSCs↓, 1,  
Total Targets: 8

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: SLC25A1, CIC
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1223  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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