Database Query Results : , , MKP1

MKP1, MAP kinase phosphatase 1: Click to Expand ⟱
Source:
Type:
MKP-1 and MKP-2 belong to the dual-specificity phosphatase family and are key regulators of MAPK signaling pathways (including ERK, JNK, and p38), which are central to cell proliferation, differentiation, and apoptosis.
-By dephosphorylating MAPKs, these phosphatases help maintain signaling homeostasis and protect cells against excessive or prolonged MAPK activation that could lead to cell death or uncontrolled proliferation.

-MKP-1 is frequently upregulated in various cancers, including breast, lung, and ovarian cancers, where it may serve as a feedback inhibitor of MAPK pathways.
- In some studies, high MKP-1 levels have been linked to resistance to chemotherapy and radiotherapy, as enhanced deactivation of MAPKs can reduce apoptosis in response to treatment-induced stress.
Scientific Papers found: Click to Expand⟱
4508- GLA,  aLinA,    α-Linolenic and γ-linolenic acids exercise differential antitumor effects on HT-29 human colorectal cancer cells
- in-vitro, Colon, HT29
Apoptosis↑, *Inflam↓, AntiCan↑, lipid-P↑, COX2↝, MKP1↝,
2651- Plum,    Oxidative Stress Inducers in Cancer Therapy: Preclinical and Clinical Evidence
- Review, Var, NA
ROS↑, TrxR↓, GSR↓, ER Stress↓, TumCCA↑, MMP↓, NF-kB↓, PI3K↓, Akt↓, mTOR↓, MKP1↓, MKP2↓, ChemoSen↑,
2005- Plum,    Plumbagin induces apoptosis in lymphoma cells via oxidative stress mediated glutathionylation and inhibition of mitogen-activated protein kinase phosphatases (MKP1/2)
- in-vivo, Nor, EL4 - in-vitro, AML, Jurkat
JNK↑, Cyt‑c↑, FasL↑, BAX↑, ROS↑, *ROS↑, MKP1↓, MKP2↓, selectivity∅, tumCV↑, Cyt‑c↑, Casp3↑, GSH/GSSG↓, ROS↑, mt-ROS↑, *ROS↑, eff↓,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 3

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

GSH/GSSG↓, 1,   GSR↓, 1,   lipid-P↑, 1,   ROS↑, 3,   mt-ROS↑, 1,   TrxR↓, 1,  

Mitochondria & Bioenergetics ⓘ

MMP↓, 1,  

Cell Death ⓘ

Akt↓, 1,   Apoptosis↑, 1,   BAX↑, 1,   Casp3↑, 1,   Cyt‑c↑, 2,   FasL↑, 1,   JNK↑, 1,   MKP1↓, 2,   MKP1↝, 1,   MKP2↓, 2,  

Transcription & Epigenetics ⓘ

tumCV↑, 1,  

Protein Folding & ER Stress ⓘ

ER Stress↓, 1,  

Cell Cycle & Senescence ⓘ

TumCCA↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

mTOR↓, 1,   PI3K↓, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↝, 1,   NF-kB↓, 1,  

Drug Metabolism & Resistance ⓘ

ChemoSen↑, 1,   eff↓, 1,   selectivity∅, 1,  

Functional Outcomes ⓘ

AntiCan↑, 1,  
Total Targets: 28

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

ROS↑, 2,  

Immune & Inflammatory Signaling ⓘ

Inflam↓, 1,  
Total Targets: 2

Scientific Paper Hit Count for: MKP1, MAP kinase phosphatase 1
2 Plumbagin
1 γ-linolenic acid (Borage Oil)
1 alpha Linolenic acid
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1225  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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