Database Query Results : , , MKP2

MKP2, MAP kinase phosphatase 2: Click to Expand ⟱
Source:
Type:
MKP-1 and MKP-2 belong to the dual-specificity phosphatase family and are key regulators of MAPK signaling pathways (including ERK, JNK, and p38), which are central to cell proliferation, differentiation, and apoptosis.
• By dephosphorylating MAPKs, these phosphatases help maintain signaling homeostasis and protect cells against excessive or prolonged MAPK activation that could lead to cell death or uncontrolled proliferation.

- Elevated MKP-2 expression has sometimes been associated with enhanced cell survival due to dampened MAPK activity, which can contribute to tumor progression and treatment resistance.
Scientific Papers found: Click to Expand⟱
2651- Plum,    Oxidative Stress Inducers in Cancer Therapy: Preclinical and Clinical Evidence
- Review, Var, NA
ROS↑, TrxR↓, GSR↓, ER Stress↓, TumCCA↑, MMP↓, NF-kB↓, PI3K↓, Akt↓, mTOR↓, MKP1↓, MKP2↓, ChemoSen↑,
2005- Plum,    Plumbagin induces apoptosis in lymphoma cells via oxidative stress mediated glutathionylation and inhibition of mitogen-activated protein kinase phosphatases (MKP1/2)
- in-vivo, Nor, EL4 - in-vitro, AML, Jurkat
JNK↑, Cyt‑c↑, FasL↑, BAX↑, ROS↑, *ROS↑, MKP1↓, MKP2↓, selectivity∅, tumCV↑, Cyt‑c↑, Casp3↑, GSH/GSSG↓, ROS↑, mt-ROS↑, *ROS↑, eff↓,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

GSH/GSSG↓, 1,   GSR↓, 1,   ROS↑, 3,   mt-ROS↑, 1,   TrxR↓, 1,  

Mitochondria & Bioenergetics ⓘ

MMP↓, 1,  

Cell Death ⓘ

Akt↓, 1,   BAX↑, 1,   Casp3↑, 1,   Cyt‑c↑, 2,   FasL↑, 1,   JNK↑, 1,   MKP1↓, 2,   MKP2↓, 2,  

Transcription & Epigenetics ⓘ

tumCV↑, 1,  

Protein Folding & ER Stress ⓘ

ER Stress↓, 1,  

Cell Cycle & Senescence ⓘ

TumCCA↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

mTOR↓, 1,   PI3K↓, 1,  

Immune & Inflammatory Signaling ⓘ

NF-kB↓, 1,  

Drug Metabolism & Resistance ⓘ

ChemoSen↑, 1,   eff↓, 1,   selectivity∅, 1,  
Total Targets: 23

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

ROS↑, 2,  
Total Targets: 1

Scientific Paper Hit Count for: MKP2, MAP kinase phosphatase 2
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1226  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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