Database Query Results : , , BMAL1

BMAL1, ARNTL: Click to Expand ⟱
Source:
Type:
BMAL1 (Brain and Muscle ARNT-Like 1), also known as ARNTL, is a core component of the circadian clock machinery. It regulates daily rhythmicity in gene expression, metabolism, cell cycle, and DNA repair mechanisms.

-BMAL1 is emerging as an important factor in cancer biology through its regulation of circadian rhythms, metabolism, and the cell cycle. Altered BMAL1 expression or disrupted oscillatory patterns have been associated with more aggressive tumors and poorer prognosis in several cancer types, including breast, colorectal, lung, and liver cancers.
Scientific Papers found: Click to Expand⟱
2071- HNK,    Identification of senescence rejuvenation mechanism of Magnolia officinalis extract including honokiol as a core ingredient
- Review, Nor, HaCaT
*ROS↓, *antiOx↑, *AntiAge↑, *MMP↑, *ECAR↓, *Glycolysis↓, *PAR-2↓, *CXCL12↑, *BMAL1↑, *mt-ROS↓, *OXPHOS↓,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Total Targets: 0

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 1,   OXPHOS↓, 1,   ROS↓, 1,   mt-ROS↓, 1,  

Mitochondria & Bioenergetics ⓘ

MMP↑, 1,  

Core Metabolism/Glycolysis ⓘ

BMAL1↑, 1,   ECAR↓, 1,   Glycolysis↓, 1,  

Migration ⓘ

CXCL12↑, 1,  

Immune & Inflammatory Signaling ⓘ

PAR-2↓, 1,  

Functional Outcomes ⓘ

AntiAge↑, 1,  
Total Targets: 11

Scientific Paper Hit Count for: BMAL1, ARNTL
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1248  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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