Database Query Results : , , miR-22

miR-22, miR-22: Click to Expand ⟱
Source:
Type:
miR-22 is a microRNA that has been widely investigated in various cancers, where it is often characterized as having tumor-suppressive functions.

-miR-22 predominantly acts as a tumor suppressor in multiple cancers, and its reduced expression is frequently associated with more aggressive tumor characteristics and poorer patient prognosis.
Scientific Papers found: Click to Expand⟱
2975- CUR,    Curcumin inhibits proliferation, migration and neointimal formation of vascular smooth muscle via activating miR-22
- in-vivo, Nor, NA
*miR-22↑, *Sp1/3/4↓,
4028- FulvicA,    Mineral pitch induces apoptosis and inhibits proliferation via modulating reactive oxygen species in hepatic cancer cells
- in-vitro, Liver, HUH7
Apoptosis↑, TumCP↓, ROS↑, NO↑, Dose↝, MMP↓, Cyt‑c↑, SOD↓, Catalase↓, GSH↑, lipid-P↑, miR-21↓, miR-22↑,
2077- PB,    Butyrate induces ROS-mediated apoptosis by modulating miR-22/SIRT-1 pathway in hepatic cancer cells
- in-vitro, Liver, HUH7
miR-22↑, SIRT1↓, ROS↑, Cyt‑c↑, Casp3↑, eff↓, TumCG↓, TumCP↓, HDAC↓, SIRT1↓, CD44↓, proMMP2↓, MMP↓, SOD↓,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 3

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

Catalase↓, 1,   GSH↑, 1,   lipid-P↑, 1,   ROS↑, 2,   SOD↓, 2,  

Mitochondria & Bioenergetics ⓘ

MMP↓, 2,  

Core Metabolism/Glycolysis ⓘ

SIRT1↓, 2,  

Cell Death ⓘ

Apoptosis↑, 1,   Casp3↑, 1,   Cyt‑c↑, 2,  

Transcription & Epigenetics ⓘ

miR-21↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

CD44↓, 1,   HDAC↓, 1,   TumCG↓, 1,  

Migration ⓘ

miR-22↑, 2,   proMMP2↓, 1,   TumCP↓, 2,  

Angiogenesis & Vasculature ⓘ

NO↑, 1,  

Drug Metabolism & Resistance ⓘ

Dose↝, 1,   eff↓, 1,  
Total Targets: 20

Pathway results for Effect on Normal Cells:


Kinase & Signal Transduction ⓘ

Sp1/3/4↓, 1,  

Migration ⓘ

miR-22↑, 1,  
Total Targets: 2

Scientific Paper Hit Count for: miR-22, miR-22
1 Curcumin
1 Shilajit/Fulvic Acid
1 Phenylbutyrate
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1249  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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