Database Query Results : , , glucoNG

glucoNG, gluconeogenesis: Click to Expand ⟱
Source:
Type:
Gluconeogenesis is the metabolic pathway through which organisms synthesize glucose from non-carbohydrate precursors. This process is crucial for maintaining blood glucose levels, especially during fasting or intense exercise. In the context of cancer, gluconeogenesis can play a significant role in tumor metabolism and growth.
Cancer cells often exhibit altered metabolic pathways, a phenomenon known as the Warburg effect, where they preferentially use glycolysis for energy production even in the presence of oxygen. However, gluconeogenesis can also be upregulated in certain cancer types, providing a source of glucose to support rapid cell proliferation.
Cancer cells can utilize various substrates for gluconeogenesis, including lactate, amino acids (especially alanine and glutamine), and glycerol. This allows tumors to generate glucose even when dietary glucose is limited.
Hormones such as glucagon and cortisol can stimulate gluconeogenesis. In cancer, the dysregulation of these hormones can contribute to altered glucose metabolism.
Key Enzymes in Gluconeogenesis
Pyruvate Carboxylase (PC)
Phosphoenolpyruvate Carboxykinase (PEPCK)
Fructose-1,6-bisphosphatase (FBPase)
Glucose-6-phosphatase (G6Pase)

The expression of gluconeogenic enzymes is often altered in various cancers, and their upregulation is generally associated with poorer prognosis.
Scientific Papers found: Click to Expand⟱
932- BBR,    The short-term effects of berberine in the liver: Narrow margins between benefits and toxicity
- in-vivo, Nor, NA
*glucoNG↓, *Glycolysis↑, *NH3↑, *NADPH/NADP+↑, *ATP↓, *toxicity↑,
1578- Citrate,    Understanding the Central Role of Citrate in the Metabolism of Cancer Cells and Tumors: An Update
- Review, Var, NA
TCA↑, FASN↑, Glycolysis↓, glucoNG↑, PFK1↓, PFK2↓, FBPase↑, TumCP↓, eff↑, ACLY↓, Dose↑, Casp3↑, Casp2↑, Casp8↑, Casp9↑, Bcl-xL↓, Mcl-1↓, IGF-1R↓, PI3K↓, Akt↓, mTOR↓, PTEN↑, ChemoSen↑, Dose?,
1593- Citrate,    Citrate Induces Apoptotic Cell Death: A Promising Way to Treat Gastric Carcinoma?
- in-vitro, GC, BGC-823 - in-vitro, GC, SGC-7901
PFK↓, Glycolysis↓, tumCV↓, cl‑Casp3↑, cl‑PARP↑, Apoptosis↑, ATP↓, ChemoSen↑, Mcl-1↓, glucoNG↑, FBPase↑, OXPHOS↓, TCA↓, β-oxidation↓, HK2↓, PDH↓, ROS↑,
1883- DCA,    In vivo metabolic response of glucose to dichloroacetate in humans
- Analysis, Var, NA
BG↓, glucoNG↓,
2491- MET,    Metformin suppresses gluconeogenesis by inhibiting mitochondrial glycerophosphate dehydrogenase
- in-vivo, Nor, NA
*glucoNG↓, *glucose↓, *mitResp↓,
2492- MET,    The Metformin Mechanism on Gluconeogenesis and AMPK Activation: The Metabolite Perspective
- Review, Nor, NA
*glucose↓, *glucoNG↓, *AMPK↑,
2493- MET,    Metformin Inhibits Gluconeogenesis by a Redox-Dependent Mechanism In Vivo
- in-vivo, Nor, NA
glucoNG↓, glucose↓,
2448- SFN,    Sulforaphane and bladder cancer: a potential novel antitumor compound
- Review, Bladder, NA
Apoptosis↑, TumCG↓, TumCI↓, TumMeta↓, glucoNG↓, ChemoSen↑, TumCCA↑, Casp3↑, Casp7↑, cl‑PARP↑, survivin↓, EGFR↓, HER2/EBBR2↓, ATP↓, Glycolysis↓, mt-OXPHOS↓, AKT1↓, HK2↓, Hif1a↓, ROS↑, NRF2↑, EMT↓, COX2↓, MMP2↓, MMP9↓, Zeb1↓, Snail↓, HDAC↓, HATs↓, MMP↓, Cyt‑c↓, Shh↓, Smo↓, Gli1↓, BioAv↝, BioAv↝, Dose↝,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 8

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

NRF2↑, 1,   OXPHOS↓, 1,   mt-OXPHOS↓, 1,   ROS↑, 2,  

Mitochondria & Bioenergetics ⓘ

ATP↓, 2,   MMP↓, 1,  

Core Metabolism/Glycolysis ⓘ

ACLY↓, 1,   AKT1↓, 1,   FASN↑, 1,   FBPase↑, 2,   glucoNG↓, 3,   glucoNG↑, 2,   glucose↓, 1,   Glycolysis↓, 3,   HK2↓, 2,   PDH↓, 1,   PFK↓, 1,   PFK1↓, 1,   PFK2↓, 1,   TCA↓, 1,   TCA↑, 1,   β-oxidation↓, 1,  

Cell Death ⓘ

Akt↓, 1,   Apoptosis↑, 2,   Bcl-xL↓, 1,   Casp2↑, 1,   Casp3↑, 2,   cl‑Casp3↑, 1,   Casp7↑, 1,   Casp8↑, 1,   Casp9↑, 1,   Cyt‑c↓, 1,   Mcl-1↓, 2,   survivin↓, 1,  

Kinase & Signal Transduction ⓘ

HER2/EBBR2↓, 1,  

Transcription & Epigenetics ⓘ

HATs↓, 1,   tumCV↓, 1,  

DNA Damage & Repair ⓘ

cl‑PARP↑, 2,  

Cell Cycle & Senescence ⓘ

TumCCA↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

EMT↓, 1,   Gli1↓, 1,   HDAC↓, 1,   IGF-1R↓, 1,   mTOR↓, 1,   PI3K↓, 1,   PTEN↑, 1,   Shh↓, 1,   Smo↓, 1,   TumCG↓, 1,  

Migration ⓘ

MMP2↓, 1,   MMP9↓, 1,   Snail↓, 1,   TumCI↓, 1,   TumCP↓, 1,   TumMeta↓, 1,   Zeb1↓, 1,  

Angiogenesis & Vasculature ⓘ

EGFR↓, 1,   Hif1a↓, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↝, 2,   ChemoSen↑, 3,   Dose?, 1,   Dose↑, 1,   Dose↝, 1,   eff↑, 1,  

Clinical Biomarkers ⓘ

BG↓, 1,   EGFR↓, 1,   HER2/EBBR2↓, 1,  
Total Targets: 68

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

NADPH/NADP+↑, 1,  

Mitochondria & Bioenergetics ⓘ

ATP↓, 1,   mitResp↓, 1,  

Core Metabolism/Glycolysis ⓘ

AMPK↑, 1,   glucoNG↓, 3,   glucose↓, 2,   Glycolysis↑, 1,   NH3↑, 1,  

Functional Outcomes ⓘ

toxicity↑, 1,  
Total Targets: 9

Scientific Paper Hit Count for: glucoNG, gluconeogenesis
3 Metformin
2 Citric Acid
1 Berberine
1 Dichloroacetate
1 Sulforaphane (mainly Broccoli)
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:126  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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