Database Query Results : , , 4-HNE

4-HNE, 4‑Hydroxynonenal: Click to Expand ⟱
Source:
Type:
4‑Hydroxynonenal (4‑HNE) is a key bioactive aldehyde generated during lipid peroxidation, and it can form adducts with proteins, DNA, and other biomolecules.

4‑HNE can act as a “double‐edged sword”. At moderate concentrations, it might activate signaling pathways that promote cell proliferation and survival, potentially contributing to tumor growth. At higher concentrations, the same molecule may induce cytotoxicity and apoptosis.

-A biomarker of ferroptosis(high levels)
-Elevated levels of 4‑HNE adducts are sometimes associated with chemoresistance and poor clinical outcomes, highlighting its potential role in prognostication.
Scientific Papers found: Click to Expand⟱
3761- H2,    Therapeutic Inhalation of Hydrogen Gas for Alzheimer's Disease Patients and Subsequent Long-Term Follow-Up as a Disease-Modifying Treatment: An Open Label Pilot Study
- Human, AD, NA
*cognitive↑, *BBB↑, *ROS↓, *NRF2↑, *Inflam↓, *NFAT↓, *FAO↓, *4-HNE↓, *PGC-1α↑, *Ferroptosis↓,
4007- K+,    The increased potassium intake improves cognitive performance and attenuates histopathological markers in a model of Alzheimer's disease
- in-vivo, AD, NA
*p‑tau↓, *cognitive↑, *Inflam↓, *ROS↓, *IL6↓, *4-HNE↓, *other↝,
4296- QC,    A Flavonoid on the Brain: Quercetin as a Potential Therapeutic Agent in Central Nervous System Disorders
- Review, AD, NA
*Inflam↓, *COX2↓, *5LO↓, *antiOx↑, *BioAv↝, *GPx↑, *SOD↑, *Ach↑, *4-HNE↓, *CREB↑, *BDNF↑, *ROS↓, *GSH↑, *IL1β↓, *IL6↓, *TNF-α↓,
2203- SK,    Shikonin suppresses small cell lung cancer growth via inducing ATF3-mediated ferroptosis to promote ROS accumulation
- in-vitro, Lung, NA
TumCP↓, Apoptosis↓, TumCMig↓, TumCI↓, Ferroptosis↑, ERK↓, GPx4↓, 4-HNE↑, ROS↑, GSH↓, ATF3↑, HDAC1↓, ac‑Histones↑,
4311- VitB1/Thiamine,    Benfotiamine treatment activates the Nrf2/ARE pathway and is neuroprotective in a transgenic mouse model of tauopathy
- in-vivo, AD, NA
*Aβ↓, *p‑tau↓, *ROS↓, *cognitive↑, *OS↑, *Mood↑, *neuroP↑, *Inflam↓, *NRF2↑, *PGC-1α↑, *AGEs↓, *4-HNE↓, *NQO1↑, *COX2↓, *TNF-α↓, *IL1β↓, *NF-kB↓, *GSK‐3β↓,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 5

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

4-HNE↑, 1,   ATF3↑, 1,   Ferroptosis↑, 1,   GPx4↓, 1,   GSH↓, 1,   ROS↑, 1,  

Core Metabolism/Glycolysis ⓘ

ac‑Histones↑, 1,  

Cell Death ⓘ

Apoptosis↓, 1,   Ferroptosis↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

ERK↓, 1,   HDAC1↓, 1,  

Migration ⓘ

TumCI↓, 1,   TumCMig↓, 1,   TumCP↓, 1,  
Total Targets: 14

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

4-HNE↓, 4,   antiOx↑, 1,   Ferroptosis↓, 1,   GPx↑, 1,   GSH↑, 1,   NQO1↑, 1,   NRF2↑, 2,   ROS↓, 4,   SOD↑, 1,  

Mitochondria & Bioenergetics ⓘ

PGC-1α↑, 2,  

Core Metabolism/Glycolysis ⓘ

CREB↑, 1,   FAO↓, 1,  

Cell Death ⓘ

Ferroptosis↓, 1,  

Transcription & Epigenetics ⓘ

Ach↑, 1,   other↝, 1,  

Proliferation, Differentiation & Cell State ⓘ

GSK‐3β↓, 1,  

Migration ⓘ

5LO↓, 1,   NFAT↓, 1,  

Barriers & Transport ⓘ

BBB↑, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 2,   IL1β↓, 2,   IL6↓, 2,   Inflam↓, 4,   NF-kB↓, 1,   TNF-α↓, 2,  

Synaptic & Neurotransmission ⓘ

BDNF↑, 1,   p‑tau↓, 2,  

Protein Aggregation ⓘ

AGEs↓, 1,   Aβ↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↝, 1,  

Clinical Biomarkers ⓘ

IL6↓, 2,  

Functional Outcomes ⓘ

cognitive↑, 3,   Mood↑, 1,   neuroP↑, 1,   OS↑, 1,  
Total Targets: 35

Scientific Paper Hit Count for: 4-HNE, 4‑Hydroxynonenal
1 Hydrogen Gas
1 Potassium
1 Quercetin
1 Shikonin
1 Vitamin B1/Thiamine
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1262  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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