Database Query Results : , , Mst1

Mst1, Mammalian Ste20-like kinase 1: Click to Expand ⟱
Source:
Type:
MST1 (Mammalian Ste20-like kinase 1), also known as STK4, is a key component of the Hippo signaling pathway and has been implicated in regulating cell proliferation, apoptosis, and tissue homeostasis.

Several studies have suggested that MST1 expression may be reduced in aggressive breast cancer subtypes.

• Prognosis: Lower MST1 levels have been associated with enhanced tumor growth and metastasis, suggesting a potential tumor suppressor role. Some reports correlate low MST1 with poorer disease-free and overall survival.
Scientific Papers found: Click to Expand⟱
2215- SK,  doxoR,    Shikonin alleviates doxorubicin-induced cardiotoxicity via Mst1/Nrf2 pathway in mice
- in-vivo, Nor, NA
*cardioP↑, *ROS↓, *Inflam↓, *Mst1↓, *NRF2↑, *eff↓, *antiOx↑, *SOD↑, *GSH↑, *TNF-α↓, BAX↓, Bcl-2↑,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Cell Death ⓘ

BAX↓, 1,   Bcl-2↑, 1,  
Total Targets: 2

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 1,   GSH↑, 1,   NRF2↑, 1,   ROS↓, 1,   SOD↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

Mst1↓, 1,  

Immune & Inflammatory Signaling ⓘ

Inflam↓, 1,   TNF-α↓, 1,  

Drug Metabolism & Resistance ⓘ

eff↓, 1,  

Functional Outcomes ⓘ

cardioP↑, 1,  
Total Targets: 10

Scientific Paper Hit Count for: Mst1, Mammalian Ste20-like kinase 1
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1266  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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