Database Query Results : , , NHE3

NHE3, Sodium/Hydrogen Exchanger 3: Click to Expand ⟱
Source:
Type:
NHE3 (Sodium/Hydrogen Exchanger 3), encoded by the SLC9A3 gene, is best known for its role in maintaining sodium and fluid balance as well as intracellular pH, particularly in epithelial tissues such as the intestine and kidney.
-well known that NHE3 activity is increased with PI3K cascade activation

• NHE3 is central to regulating the intracellular pH by exchanging intracellular H⁺ for extracellular Na⁺.
• By controlling pH and ion balance, NHE3 indirectly contributes to cell volume regulation, nutrient absorption, and overall epithelial barrier integrity.
• In non-transformed tissues, NHE3 activity supports normal metabolic functions and cellular homeostasis.

Expression in Cancer
• Tumor Microenvironment: Cancer cells often face an acidic microenvironment; alterations in NHE activity (including NHE3) could help tumor cells adapt by regulating intracellular pH.
-The degree of NHE3 expression (upregulation or downregulation) may vary with cancer type and the specific tumor microenvironment, influencing local pH balance and, consequently, tumor behavior.
Scientific Papers found: Click to Expand⟱
2220- SK,    Shikonin Alleviates Gentamicin-Induced Renal Injury in Rats by Targeting Renal Endocytosis, SIRT1/Nrf2/HO-1, TLR-4/NF-κB/MAPK, and PI3K/Akt Cascades
- in-vivo, Nor, NA
*RenoP↑, *ROS↓, *SIRT1↓, *NRF2↑, *HO-1↑, *GSH↑, *TAC↑, *SOD↑, *MDA↓, *NO↓, *iNOS↓, *NHE3↑, *PI3K↑,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Total Targets: 0

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

GSH↑, 1,   HO-1↑, 1,   MDA↓, 1,   NRF2↑, 1,   ROS↓, 1,   SOD↑, 1,   TAC↑, 1,  

Core Metabolism/Glycolysis ⓘ

SIRT1↓, 1,  

Cell Death ⓘ

iNOS↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

PI3K↑, 1,  

Angiogenesis & Vasculature ⓘ

NO↓, 1,  

Barriers & Transport ⓘ

NHE3↑, 1,  

Functional Outcomes ⓘ

RenoP↑, 1,  
Total Targets: 13

Scientific Paper Hit Count for: NHE3, Sodium/Hydrogen Exchanger 3
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1270  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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