Database Query Results : , , GSS

GSS, Glutathione Synthetase: Click to Expand ⟱
Source:
Type:
GSS (Glutathione Synthetase) is a key enzyme in the synthesis of glutathione (GSH), an essential intracellular antioxidant that protects cells from oxidative stress and contributes to detoxification processes.
-GSS catalyzes the second step in glutathione synthesis, converting γ-glutamylcysteine and glycine into glutathione.

-Elevated expression of GSS has been observed in certain tumors as cancer cells adapt to high ROS levels. This adaptation can help protect malignant cells from apoptosis and contribute to chemoresistance.
Scientific Papers found: Click to Expand⟱
2394- CAP,    Capsaicin acts as a novel NRF2 agonist to suppress ethanol induced gastric mucosa oxidative damage by directly disrupting the KEAP1-NRF2 interaction
- in-vitro, Nor, GES-1
*mtDam↓, *NRF2↑, *HO-1↑, *Trx↑, *GSS↑, *NQO1↑, *Keap1↓, *ROS↓, *PKM2↓, *LDHA↓, *Inflam↓,
2915- LT,    Luteolin promotes apoptotic cell death via upregulation of Nrf2 expression by DNA demethylase and the interaction of Nrf2 with p53 in human colon cancer cells
- in-vitro, Colon, HT29 - in-vitro, CRC, SNU-407 - in-vitro, Nor, FHC
DNMTs↓, TET1↑, NRF2↑, HDAC↓, tumCV↓, BAX↑, Casp9↑, Casp3↑, Bcl-2↓, ROS↓, GSS↑, Catalase↑, HO-1↑, DNMT1↓, DNMT3A↓, TET1↑, TET3↑, TET2↓, P53↑, P21↑,
2225- SK,    Shikonin protects skin cells against oxidative stress and cellular dysfunction induced by fine particulate matter
- in-vitro, Nor, HaCaT
*antiOx↑, *ROS↓, *GSH↑, *GCLC↑, *GSS↑, *Akt↑, *NRF2↑,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 3

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

Catalase↑, 1,   GSS↑, 1,   HO-1↑, 1,   NRF2↑, 1,   ROS↓, 1,  

Cell Death ⓘ

BAX↑, 1,   Bcl-2↓, 1,   Casp3↑, 1,   Casp9↑, 1,  

Transcription & Epigenetics ⓘ

TET3↑, 1,   tumCV↓, 1,  

DNA Damage & Repair ⓘ

DNMT1↓, 1,   DNMT3A↓, 1,   DNMTs↓, 1,   P53↑, 1,  

Cell Cycle & Senescence ⓘ

P21↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

HDAC↓, 1,  

Migration ⓘ

TET1↑, 2,  

Drug Metabolism & Resistance ⓘ

TET2↓, 1,  
Total Targets: 19

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 1,   GCLC↑, 1,   GSH↑, 1,   GSS↑, 2,   HO-1↑, 1,   Keap1↓, 1,   NQO1↑, 1,   NRF2↑, 2,   ROS↓, 2,   Trx↑, 1,  

Mitochondria & Bioenergetics ⓘ

mtDam↓, 1,  

Core Metabolism/Glycolysis ⓘ

LDHA↓, 1,   PKM2↓, 1,  

Cell Death ⓘ

Akt↑, 1,  

Immune & Inflammatory Signaling ⓘ

Inflam↓, 1,  
Total Targets: 15

Scientific Paper Hit Count for: GSS, Glutathione Synthetase
1 Capsaicin
1 Luteolin
1 Shikonin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1271  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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