Database Query Results : , , HSPs

HSPs, Heat shock proteins: Click to Expand ⟱
Source:
Type:
Heat shock proteins (HSPs) are a diverse group of molecular chaperones that assist in proper protein folding, stabilization of proteins against aggregation, and protein trafficking. In cancer, HSPs are often overexpressed, which can help tumor cells survive the stressful conditions present in the tumor microenvironment (such as hypoxia, oxidative stress, and nutrient deprivation).

-Overexpression: Many cancers exhibit high levels of HSPs compared to their normal tissue counterparts. Overexpression of chaperones like HSP27, HSP70, and HSP90 is common in various tumors.
Scientific Papers found: Click to Expand⟱
2640- Api,    Apigenin: A Promising Molecule for Cancer Prevention
- Review, Var, NA
chemoPv↑, ITGB4↓, TumCI↓, TumMeta↓, Akt↓, ERK↓, p‑JNK↓, *Inflam↓, *PKCδ↓, *MAPK↓, EGFR↓, CK2↓, TumCCA↑, CDK1↓, P53↓, P21↑, Bax:Bcl2↑, Cyt‑c↑, APAF1↑, Casp↑, cl‑PARP↑, VEGF↓, Hif1a↓, IGF-1↓, IGFBP3↑, E-cadherin↑, β-catenin/ZEB1↓, HSPs↓, Telomerase↓, FASN↓, MMPs↓, HER2/EBBR2↓, CK2↓, eff↑, AntiAg↑, eff↑, FAK↓, ROS↑, Bcl-2↓, Cyt‑c↑, cl‑Casp3↑, cl‑Casp7↑, cl‑Casp8↑, cl‑Casp9↑, cl‑IAP2↑, AR↓, PSA↓, p‑pRB↓, p‑GSK‐3β↓, CDK4↓, ChemoSen↑, Ca+2↑, cal2↑,
3687- Ash,    Role of Withaferin A and Its Derivatives in the Management of Alzheimer’s Disease: Recent Trends and Future Perspectives
- Review, AD, NA
*Aβ↓, *tau↓, *HSPs↝, *antiOx↑, *ROS↓, *Inflam↓, *neuroP↑, *cognitive↑, *NF-kB↓, *HO-1↑, *memory↑, *AChE↓, *BChE↓, *ChAT↑, *Ach↑,
4159- dietSTF,  2DG,  CRMs,    Meal size and frequency affect neuronal plasticity and vulnerability to disease: cellular and molecular mechanisms
- Review, AD, NA
*BDNF↑, *HSPs↑, *eff↑,
2252- MF,  HPT,    Cellular Response to ELF-MF and Heat: Evidence for a Common Involvement of Heat Shock Proteins?
- Review, NA, NA
HSPs∅, *HSPs↑, eff↝, *eff↑, eff↑, eff↓,
3457- MF,    Cellular stress response to extremely low‐frequency electromagnetic fields (ELF‐EMF): An explanation for controversial effects of ELF‐EMF on apoptosis
- Review, Var, NA
Apoptosis↑, H2O2↑, ROS↑, eff↑, eff↑, Ca+2↑, MAPK↑, *Catalase↑, *SOD1↑, *GPx1↑, *GPx4↑, *NRF2↑, TumAuto↑, ER Stress↑, HSPs↑, SIRT3↑, ChemoSen↑, UPR↑, other↑, PI3K↓, JNK↑, p38↑, eff↓, *toxicity?,
3352- QC,    A review of quercetin: Antioxidant and anticancer properties
- Review, Var, NA
*antiOx↑, *lipid-P↓, *TNF-α↓, *NF-kB↓, *COX2↓, *IronCh↑, P53↓, TumCCA↑, HSPs↓, P21↓, RAS↓, ER(estro)↑, OS?,
3372- QC,  FIS,  KaempF,    Anticancer Potential of Selected Flavonols: Fisetin, Kaempferol, and Quercetin on Head and Neck Cancers
- Review, HNSCC, NA
ROCK1↑, TumCCA↓, HSPs↓, RAS↓, ROS↑, Ca+2↑, MMP↓, Cyt‑c↑, Endon↑, MMP9↓, MMP2↓, MMP7↓, MMP-10↓, VEGF↓, NF-kB↓, p65↓, iNOS↓, COX2↓, uPA↓, PI3K↓, FAK↓, MEK↓, ERK↓, JNK↓, p38↓, cJun↓, FOXO3↑,
4199- SFN,    Sulforaphane and Brain Health: From Pathways of Action to Effects on Specific Disorders
- Review, AD, NA - Review, Park, NA
*BBB↑, *BDNF↑, *neuroG↑, *NRF2↑, *HO-1↑, *Catalase↑, *SOD↑, *HSPs↑, *GSTs↑, *Trx↑, *GPx↑, *GSR↑, *GSH↑, *NQO1↑, *GutMicro↑, *Inflam↓, *neuroP↑,
3648- SIL,    Silymarin/Silybin and Chronic Liver Disease: A Marriage of Many Years
- Review, NA, NA
*antiOx↑, *Inflam↓, *lipid-P↓, *necrosis↓, *hepatoP↑, *IL1↓, *IL6↓, *TNF-α↓, *IFN-γ↓, MAPK↓, Apoptosis↑, Cyt‑c↑, Casp3↑, Casp9↑, *PPARγ↑, *GLUT4↑, *HSPs↓, *HSP27↑, *Trx↑, *SIRT1↑, *ALAT↓, *GSH↑, *lipid-P↓, *TNF-α↓, TumCG↓, P21↑, CDK4↑,
3309- SIL,    Silymarin as a Natural Antioxidant: An Overview of the Current Evidence and Perspectives
- Review, NA, NA
*ROS↓, *IronCh↑, *MMP↑, *NRF2↑, *Inflam↓, *hepatoP↑, *HSPs↑, *Trx↑, *SIRT2↑, *GSH↑, *ROS↑, *NADPH↓, *iNOS↓, *NF-kB↓, *BioAv↓, *Dose↝, *BioAv↑,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 10

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned ⓘ

chemoPv↑, 1,  

Redox & Oxidative Stress ⓘ

H2O2↑, 1,   ROS↑, 3,   SIRT3↑, 1,  

Mitochondria & Bioenergetics ⓘ

MEK↓, 1,   MMP↓, 1,  

Core Metabolism/Glycolysis ⓘ

FASN↓, 1,  

Cell Death ⓘ

Akt↓, 1,   APAF1↑, 1,   Apoptosis↑, 2,   Bax:Bcl2↑, 1,   Bcl-2↓, 1,   Casp↑, 1,   Casp3↑, 1,   cl‑Casp3↑, 1,   cl‑Casp7↑, 1,   cl‑Casp8↑, 1,   Casp9↑, 1,   cl‑Casp9↑, 1,   CK2↓, 2,   Cyt‑c↑, 4,   Endon↑, 1,   cl‑IAP2↑, 1,   iNOS↓, 1,   JNK↓, 1,   JNK↑, 1,   p‑JNK↓, 1,   MAPK↓, 1,   MAPK↑, 1,   p38↓, 1,   p38↑, 1,   Telomerase↓, 1,  

Kinase & Signal Transduction ⓘ

HER2/EBBR2↓, 1,  

Transcription & Epigenetics ⓘ

cJun↓, 1,   other↑, 1,   p‑pRB↓, 1,  

Protein Folding & ER Stress ⓘ

ER Stress↑, 1,   HSPs↓, 3,   HSPs↑, 1,   HSPs∅, 1,   UPR↑, 1,  

Autophagy & Lysosomes ⓘ

TumAuto↑, 1,  

DNA Damage & Repair ⓘ

P53↓, 2,   cl‑PARP↑, 1,  

Cell Cycle & Senescence ⓘ

CDK1↓, 1,   CDK4↓, 1,   CDK4↑, 1,   P21↓, 1,   P21↑, 2,   TumCCA↓, 1,   TumCCA↑, 2,  

Proliferation, Differentiation & Cell State ⓘ

ERK↓, 2,   FOXO3↑, 1,   p‑GSK‐3β↓, 1,   IGF-1↓, 1,   IGFBP3↑, 1,   PI3K↓, 2,   RAS↓, 2,   TumCG↓, 1,  

Migration ⓘ

AntiAg↑, 1,   Ca+2↑, 3,   cal2↑, 1,   E-cadherin↑, 1,   FAK↓, 2,   ITGB4↓, 1,   MMP-10↓, 1,   MMP2↓, 1,   MMP7↓, 1,   MMP9↓, 1,   MMPs↓, 1,   ROCK1↑, 1,   TumCI↓, 1,   TumMeta↓, 1,   uPA↓, 1,   β-catenin/ZEB1↓, 1,  

Angiogenesis & Vasculature ⓘ

EGFR↓, 1,   Hif1a↓, 1,   VEGF↓, 2,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 1,   NF-kB↓, 1,   p65↓, 1,   PSA↓, 1,  

Hormonal & Nuclear Receptors ⓘ

AR↓, 1,   ER(estro)↑, 1,  

Drug Metabolism & Resistance ⓘ

ChemoSen↑, 2,   eff↓, 2,   eff↑, 5,   eff↝, 1,  

Clinical Biomarkers ⓘ

AR↓, 1,   EGFR↓, 1,   HER2/EBBR2↓, 1,   PSA↓, 1,  

Functional Outcomes ⓘ

OS?, 1,  
Total Targets: 93

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 3,   Catalase↑, 2,   GPx↑, 1,   GPx1↑, 1,   GPx4↑, 1,   GSH↑, 3,   GSR↑, 1,   GSTs↑, 1,   HO-1↑, 2,   lipid-P↓, 3,   NQO1↑, 1,   NRF2↑, 3,   ROS↓, 2,   ROS↑, 1,   SOD↑, 1,   SOD1↑, 1,   Trx↑, 3,  

Metal & Cofactor Biology ⓘ

IronCh↑, 2,  

Mitochondria & Bioenergetics ⓘ

MMP↑, 1,  

Core Metabolism/Glycolysis ⓘ

ALAT↓, 1,   NADPH↓, 1,   PPARγ↑, 1,   SIRT1↑, 1,   SIRT2↑, 1,  

Cell Death ⓘ

iNOS↓, 1,   MAPK↓, 1,   necrosis↓, 1,  

Transcription & Epigenetics ⓘ

Ach↑, 1,  

Protein Folding & ER Stress ⓘ

HSP27↑, 1,   HSPs↓, 1,   HSPs↑, 4,   HSPs↝, 1,  

Proliferation, Differentiation & Cell State ⓘ

neuroG↑, 1,  

Migration ⓘ

PKCδ↓, 1,  

Barriers & Transport ⓘ

BBB↑, 1,   GLUT4↑, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 1,   IFN-γ↓, 1,   IL1↓, 1,   IL6↓, 1,   Inflam↓, 5,   NF-kB↓, 3,   TNF-α↓, 3,  

Synaptic & Neurotransmission ⓘ

AChE↓, 1,   BChE↓, 1,   BDNF↑, 2,   ChAT↑, 1,   tau↓, 1,  

Protein Aggregation ⓘ

Aβ↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 1,   BioAv↑, 1,   Dose↝, 1,   eff↑, 2,  

Clinical Biomarkers ⓘ

ALAT↓, 1,   GutMicro↑, 1,   IL6↓, 1,  

Functional Outcomes ⓘ

cognitive↑, 1,   hepatoP↑, 2,   memory↑, 1,   neuroP↑, 2,   toxicity?, 1,  
Total Targets: 61

Scientific Paper Hit Count for: HSPs, Heat shock proteins
2 Magnetic Fields
2 Quercetin
2 Silymarin (Milk Thistle) silibinin
1 Apigenin (mainly Parsley)
1 Ashwagandha(Withaferin A)
1 diet Short Term Fasting
1 2-DeoxyGlucose
1 Calorie Restriction Mimetics
1 Hyperthermia
1 Fisetin
1 Kaempferol
1 Sulforaphane (mainly Broccoli)
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1272  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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