Database Query Results : , , GPI

GPI, Glucose-6-Phosphate Isomerase: Click to Expand ⟱
Source:
Type:
GPI (Glucose-6-Phosphate Isomerase)
– GPI catalyzes the reversible interconversion of glucose-6-phosphate and fructose-6-phosphate, a critical step in glycolysis and gluconeogenesis.

GPI can contribute to the enhanced glycolytic activity observed in many tumors.

– Tumor Aggressiveness: Elevated levels of GPI (both intracellular and secreted forms) have been correlated with enhanced invasiveness and metastatic potential, particularly in cancers such as breast, lung, and gastric cancers.

– Poor Outcomes: Increased GPI may serve as a marker for aggressive tumor phenotypes and is often associated with poorer clinical outcomes. In some studies, high serum levels of GPI/AMF have been proposed as indicative of advanced disease and a worse prognosis.
Scientific Papers found: Click to Expand⟱
2291- Ba,  BA,    Baicalein and Baicalin Promote Melanoma Apoptosis and Senescence via Metabolic Inhibition
- in-vitro, Melanoma, SK-MEL-28 - in-vitro, Melanoma, A375
LDHA↓, ENO1↓, PKM2↓, GLUT1↓, GLUT3↓, HK2↓, PFK1↓, GPI↓, TPI↓, GlucoseCon↓, TumCG↓, TumCP↓, mTORC1↓, Hif1a↓, Ki-67↓,
2431- QC,    The Protective Effect of Quercetin against the Cytotoxicity Induced by Fumonisin B1 in Sertoli Cells
- in-vitro, Nor, TM4
*Apoptosis↓, *ROS↓, *antiOx↓, *MMP↑, *GPI↑, *HK2↑, *ALDOA↑, *PKM1↑, *LDHA↑, *PFKL↑,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


Core Metabolism/Glycolysis ⓘ

ENO1↓, 1,   GlucoseCon↓, 1,   GPI↓, 1,   HK2↓, 1,   LDHA↓, 1,   PFK1↓, 1,   PKM2↓, 1,   TPI↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

mTORC1↓, 1,   TumCG↓, 1,  

Migration ⓘ

Ki-67↓, 1,   TumCP↓, 1,  

Angiogenesis & Vasculature ⓘ

Hif1a↓, 1,  

Barriers & Transport ⓘ

GLUT1↓, 1,   GLUT3↓, 1,  

Clinical Biomarkers ⓘ

Ki-67↓, 1,  
Total Targets: 16

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↓, 1,   ROS↓, 1,  

Mitochondria & Bioenergetics ⓘ

MMP↑, 1,  

Core Metabolism/Glycolysis ⓘ

ALDOA↑, 1,   GPI↑, 1,   HK2↑, 1,   LDHA↑, 1,   PFKL↑, 1,   PKM1↑, 1,  

Cell Death ⓘ

Apoptosis↓, 1,  
Total Targets: 10

Scientific Paper Hit Count for: GPI, Glucose-6-Phosphate Isomerase
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1286  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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