Database Query Results : , , PDK3

PDK3, Pyruvate Dehydrogenase Kinase 3: Click to Expand ⟱
Source:
Type:
Pyruvate Dehydrogenase Kinase 3 (PDK3)
– PDK3 is one of the four isoenzymes of pyruvate dehydrogenase kinase (PDK1–4) that phosphorylate and inactivate the pyruvate dehydrogenase (PDH) complex.

– By inhibiting PDH, PDK3 reduces the conversion of pyruvate into acetyl-CoA, thereby diverting pyruvate from entry into the tricarboxylic acid (TCA) cycle.
– This shift promotes glycolytic metabolism (even under aerobic conditions), a hallmark of the Warburg effect observed in many cancers.

– PDK3 is typically upregulated in response to hypoxia or metabolic stress, conditions commonly encountered in the tumor microenvironment.
– Its expression can be regulated by hypoxia-inducible factor 1-alpha (HIF-1α) and other metabolic regulators, contributing to the adaptive metabolic reprogramming of cancer cells.

– Upregulated Expression: Elevated levels of PDK3 have been observed in several cancer types, including lung, colon, and breast cancers.
– Metabolic Reprogramming: Overexpression of PDK3 supports the preferential use of glycolysis over oxidative phosphorylation, allowing cancer cells to adapt to hypoxic conditions and rapid proliferation.
Scientific Papers found: Click to Expand⟱
2781- CHr,  PBG,    Chrysin a promising anticancer agent: recent perspectives
- Review, Var, NA
PI3K↓, Akt↓, mTOR↓, MMP9↑, uPA↓, VEGF↓, AR↓, Casp↑, TumMeta↓, TumCCA↑, angioG↓, BioAv↓, *hepatoP↑, *neuroP↑, *SOD↑, *GPx↑, *ROS↓, *Inflam↓, *Catalase↑, *MDA↓, ROS↓, BBB↑, Half-Life↓, BioAv↑, ROS↑, eff↑, ROS↑, ROS↑, lipid-P↑, ER Stress↑, NOTCH1↑, NRF2↓, p‑FAK↓, Rho↓, PCNA↓, COX2↓, NF-kB↓, PDK1↓, PDK3↑, GLUT1↓, Glycolysis↓, mt-ATP↓, Ki-67↓, cMyc↓, ROCK1↓, TOP1↓, TNF-α↓, IL1β↓, CycB/CCNB1↓, CDK2↓, EMT↓, STAT3↓, PD-L1↓, IL2↑,
2300- QC,    Flavonoids Targeting HIF-1: Implications on Cancer Metabolism
- Review, Var, NA
AntiTum↑, Hif1a↓, *Hif1a↑, Glycolysis↓, HK2↓, PDK3↓, PFKP?,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

lipid-P↑, 1,   NRF2↓, 1,   ROS↓, 1,   ROS↑, 3,  

Mitochondria & Bioenergetics ⓘ

mt-ATP↓, 1,  

Core Metabolism/Glycolysis ⓘ

cMyc↓, 1,   Glycolysis↓, 2,   HK2↓, 1,   PDK1↓, 1,   PDK3↓, 1,   PDK3↑, 1,   PFKP?, 1,  

Cell Death ⓘ

Akt↓, 1,   Casp↑, 1,  

Protein Folding & ER Stress ⓘ

ER Stress↑, 1,  

DNA Damage & Repair ⓘ

PCNA↓, 1,  

Cell Cycle & Senescence ⓘ

CDK2↓, 1,   CycB/CCNB1↓, 1,   TumCCA↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

EMT↓, 1,   mTOR↓, 1,   NOTCH1↑, 1,   PI3K↓, 1,   STAT3↓, 1,   TOP1↓, 1,  

Migration ⓘ

p‑FAK↓, 1,   Ki-67↓, 1,   MMP9↑, 1,   Rho↓, 1,   ROCK1↓, 1,   TumMeta↓, 1,   uPA↓, 1,  

Angiogenesis & Vasculature ⓘ

angioG↓, 1,   Hif1a↓, 1,   VEGF↓, 1,  

Barriers & Transport ⓘ

BBB↑, 1,   GLUT1↓, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 1,   IL1β↓, 1,   IL2↑, 1,   NF-kB↓, 1,   PD-L1↓, 1,   TNF-α↓, 1,  

Hormonal & Nuclear Receptors ⓘ

AR↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 1,   BioAv↑, 1,   eff↑, 1,   Half-Life↓, 1,  

Clinical Biomarkers ⓘ

AR↓, 1,   Ki-67↓, 1,   PD-L1↓, 1,  

Functional Outcomes ⓘ

AntiTum↑, 1,  
Total Targets: 52

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

Catalase↑, 1,   GPx↑, 1,   MDA↓, 1,   ROS↓, 1,   SOD↑, 1,  

Angiogenesis & Vasculature ⓘ

Hif1a↑, 1,  

Immune & Inflammatory Signaling ⓘ

Inflam↓, 1,  

Functional Outcomes ⓘ

hepatoP↑, 1,   neuroP↑, 1,  
Total Targets: 9

Scientific Paper Hit Count for: PDK3, Pyruvate Dehydrogenase Kinase 3
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1287  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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