Database Query Results : , , PDHA1

PDHA1, Pyruvate Dehydrogenase E1 Alpha 1 Subunit: Click to Expand ⟱

Source:

Type:

PDHA1 (Pyruvate Dehydrogenase E1 Alpha 1 Subunit)
– PDHA1 encodes the alpha subunit of the pyruvate dehydrogenase (PDH) complex, which is crucial for converting pyruvate into acetyl-CoA.

– This step links glycolysis to the tricarboxylic acid (TCA) cycle and oxidative phosphorylation, making PDHA1 a key regulator of cellular energy metabolism.

– Proper PDHA1 function supports oxidative metabolism, whereas impaired activity can shift metabolism toward a glycolytic phenotype (commonly referred to as the Warburg effect) in cancer cells.

-Low PDHA1 expression or activity may be associated with enhanced glycolysis, leading to increased tumor proliferation and survival under stress.

– Clinical Outcome: In several cancer types, reduced PDHA1 levels (or increased PDH inhibition) have been correlated with more aggressive disease and poorer outcomes, suggesting a potential prognostic role.

Scientific Papers found: Click to Expand⟱

2310-

EGCG,

Epigallocatechin-3-gallate downregulates PDHA1 interfering the metabolic pathways in human herpesvirus 8 harboring primary effusion lymphoma cells

in-vitro,

lymphoma,

PEL

GLUT3↑, PDHA1↓, GDH↓, ROS↑, Glycolysis↓, OXPHOS↓,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:

Redox & Oxidative Stress ⓘ

OXPHOS↓, 1, ROS↑, 1,

Core Metabolism/Glycolysis ⓘ

GDH↓, 1, Glycolysis↓, 1, PDHA1↓, 1,

Barriers & Transport ⓘ

GLUT3↑, 1,
Total Targets: 6

Pathway results for Effect on Normal Cells:

Total Targets: 0

Scientific Paper Hit Count for: PDHA1, Pyruvate Dehydrogenase E1 Alpha 1 Subunit

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells