Database Query Results : , , R5P

R5P, ribose-5-phosphate: Click to Expand ⟱
Source:
Type:
R5P is a key metabolite in the pentose phosphate pathway (PPP), where it plays a critical role in generating ribonucleotide precursors for RNA and DNA synthesis.
The PPP also produces NADPH, which is vital for reductive biosynthesis and protecting cells against oxidative stress.
R5P itself is a metabolite rather than a protein or gene product, its levels (or the activity of enzymes that regulate its production) have been associated with tumor biology and outcome in several cancer types. Much of the published data focuses on enzymes such as transketolase, transaldolase, and glucose-6-phosphate dehydrogenase (G6PD), which regulate R5P production.

-Elevated PPP activity—reflected in increased production of R5P—has been linked to enhanced cell proliferation, aggressive tumor behavior, and poorer prognosis across several cancer types including breast, lung, colorectal, hepatocellular carcinoma, and potentially gliomas.
Scientific Papers found: Click to Expand⟱
2332- RES,    Resveratrol’s Anti-Cancer Effects through the Modulation of Tumor Glucose Metabolism
- Review, Var, NA
Glycolysis↓, GLUT1↓, PFK1↓, Hif1a↓, ROS↑, PDH↑, AMPK↑, TumCG↓, TumCI↓, TumCP↓, p‑NF-kB↓, SIRT1↑, SIRT3↑, LDH↓, PI3K↓, mTOR↓, PKM2↓, R5P↝, G6PD↓, TKT↝, talin↓, HK2↓, GRP78/BiP↑, GlucoseCon↓, ER Stress↑, Warburg↓, PFK↓,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

ROS↑, 1,   SIRT3↑, 1,   TKT↝, 1,  

Core Metabolism/Glycolysis ⓘ

AMPK↑, 1,   G6PD↓, 1,   GlucoseCon↓, 1,   Glycolysis↓, 1,   HK2↓, 1,   LDH↓, 1,   PDH↑, 1,   PFK↓, 1,   PFK1↓, 1,   PKM2↓, 1,   R5P↝, 1,   SIRT1↑, 1,   Warburg↓, 1,  

Protein Folding & ER Stress ⓘ

ER Stress↑, 1,   GRP78/BiP↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

mTOR↓, 1,   PI3K↓, 1,   TumCG↓, 1,  

Migration ⓘ

talin↓, 1,   TumCI↓, 1,   TumCP↓, 1,  

Angiogenesis & Vasculature ⓘ

Hif1a↓, 1,  

Barriers & Transport ⓘ

GLUT1↓, 1,  

Immune & Inflammatory Signaling ⓘ

p‑NF-kB↓, 1,  

Clinical Biomarkers ⓘ

LDH↓, 1,  
Total Targets: 28

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: R5P, ribose-5-phosphate
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1293  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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