Database Query Results : , , PFKFB2

PFKFB2, 6-Phosphofructo-2-Kinase/Fructose-2,6-Bisphosphatase 2: Click to Expand ⟱
Source:
Type:
PFKFB2 (6-Phosphofructo-2-Kinase/Fructose-2,6-Bisphosphatase 2) is one of the isoenzymes responsible for regulating the intracellular levels of fructose-2,6-bisphosphate, a key activator of phosphofructokinase-1 (PFK-1) in glycolysis. Its role in cancer metabolism is of increasing interest due to its involvement in regulating glycolytic flux.

• In many cancers, increased glycolytic activity is a hallmark. Upregulation of PFKFB2 in some tumors can contribute to this metabolic reprogramming, although expression patterns may be context- and tissue-specific.

• Both upregulation and, in some settings, downregulation have been reported, reflecting the enzyme’s complex involvement in metabolic regulation and potential feedback mechanisms within the tumor microenvironment.

• Some studies have correlated high PFKFB2 expression with aggressive tumor characteristics, such as increased proliferation, enhanced glycolysis, and potentially poorer clinical outcomes.

• In certain cancers, elevated levels of PFKFB2 may indicate a metabolic phenotype that favors tumor growth and resistance to stress, potentially serving as a marker of poor prognosis.
Scientific Papers found: Click to Expand⟱
2444- SFN,    Sulforaphane Delays Fibroblast Senescence by Curbing Cellular Glucose Uptake, Increased Glycolysis, and Oxidative Damage
- in-vitro, Nor, MRC-5
*GlucoseCon↓, *ROS↓, *Trx↓, *HK2↓, *NRF2↑, *Catalase↑, *TXNIP↑, *PFKFB2↓, *G6PD↑,
2417- SK,    Shikonin inhibits the Warburg effect, cell proliferation, invasion and migration by downregulating PFKFB2 expression in lung cancer
- in-vitro, Lung, A549 - in-vitro, Lung, H446
TumCP↓, TumCMig↓, TumCI↓, GlucoseCon↓, lactateProd↓, PFKFB2↓, Warburg↓, GLUT1∅, LDHA∅, PKM2∅, GLUT3∅, PDH∅,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


Core Metabolism/Glycolysis ⓘ

GlucoseCon↓, 1,   lactateProd↓, 1,   LDHA∅, 1,   PDH∅, 1,   PFKFB2↓, 1,   PKM2∅, 1,   Warburg↓, 1,  

Migration ⓘ

TumCI↓, 1,   TumCMig↓, 1,   TumCP↓, 1,  

Barriers & Transport ⓘ

GLUT1∅, 1,   GLUT3∅, 1,  
Total Targets: 12

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

Catalase↑, 1,   NRF2↑, 1,   ROS↓, 1,   Trx↓, 1,  

Core Metabolism/Glycolysis ⓘ

G6PD↑, 1,   GlucoseCon↓, 1,   HK2↓, 1,   PFKFB2↓, 1,  

Migration ⓘ

TXNIP↑, 1,  
Total Targets: 9

Scientific Paper Hit Count for: PFKFB2, 6-Phosphofructo-2-Kinase/Fructose-2,6-Bisphosphatase 2
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1307  State#:%  Dir#:%
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