Database Query Results : , , TOP2

TOP2, Topoisomerase II: Click to Expand ⟱
Source:
Type:
Topoisomerase II (Top2) is a critical nuclear enzyme involved in managing the topology of DNA during essential cellular processes like replication, transcription, recombination, and chromosomal segregation.

- Rapidly dividing cells, including many cancer cells, often show higher Top2 expression.
- In several cancers, such as breast, lung, and hematological malignancies, increased Top2 expression has been correlated with more aggressive tumor subtypes and poorer clinical outcomes.
- The level of Top2 expression can sometimes be used as a prognostic marker, informing predictions about disease progression and potentially patient survival.
Scientific Papers found: Click to Expand⟱
3391- ART/DHA,    Antitumor Activity of Artemisinin and Its Derivatives: From a Well-Known Antimalarial Agent to a Potential Anticancer Drug
- Review, Var, NA
TumCP↓, TumMeta↓, angioG↓, TumVol↓, BioAv↓, Half-Life↓, BioAv↑, eff↑, eff↓, ROS↑, selectivity↑, TumCCA↑, survivin↓, BAX↑, Casp3↓, Casp8↑, Casp9↑, CDC25↓, CycB/CCNB1↓, NF-kB↓, cycD1/CCND1↓, cycE/CCNE↓, E2Fs↓, P21↑, p27↑, ADP:ATP↑, MDM2↓, VEGF↓, IL8↓, COX2↓, MMP9↓, ER Stress↓, cMyc↓, GRP78/BiP↑, DNAdam↑, AP-1↓, MMP2↓, PKCδ↓, Raf↓, ERK↓, JNK↓, PCNA↓, CDK2↓, CDK4↓, TOP2↓, uPA↓, MMP7↓, TIMP2↑, Cdc42↑, E-cadherin↑,
2617- Ba,    Potential of baicalein in the prevention and treatment of cancer: A scientometric analyses based review
- Review, Var, NA
Ca+2↑, MMP2↓, MMP9↓, Vim↓, Snail↓, E-cadherin↑, Wnt↓, β-catenin/ZEB1↓, p‑Akt↓, p‑mTOR↓, NF-kB↓, i-ROS↑, Bcl-2↓, BAX↑, Cyt‑c↑, Casp3↑, Casp9↑, STAT3↓, IL6↓, MMP2↓, MMP9↓, NOTCH↓, PPARγ↓, p‑NRF2↓, HK2↓, LDHA↓, PDK1↓, Glycolysis↓, PTEN↑, Akt↓, Hif1a↓, MMP↓, VEGF↓, VEGFR2↓, TOP2↓, uPA↓, TIMP1↓, TIMP2↓, cMyc↓, TrxR↓, ASK1↑, Vim↓, ZO-1↑, E-cadherin↑, SOX2↓, OCT4↓, Shh↓, Smo↓, Gli1↓, N-cadherin↓, XIAP↓,
2767- Bos,    The potential role of boswellic acids in cancer prevention and treatment
- Review, Var, NA
*Inflam↓, AntiCan↑, *MAPK↑, *Ca+2↝, p‑ERK↓, TumCI↓, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4↓, p‑RB1↓, *NF-kB↓, *TNF-α↓, NF-kB↓, IKKα↓, MCP1↓, IL1α↓, MIP2↓, VEGF↓, Tf↓, COX2↓, MMP9↓, CXCR4↓, VEGF↓, eff↑, PPARα↓, lipid-P?, STAT3↓, TOP1↓, TOP2↑, 5HT↓, p‑PDGFR-BB↓, PDGF↓, AR↓, DR5↑, angioG↓, DR4↑, Casp3↑, Casp8↑, cl‑PARP↑, eff↑, chemoPv↑, Wnt↓, β-catenin/ZEB1↓, ascitic↓, Let-7↑, miR-200b↑, eff↑, MMP1↓, MMP2↓, eff↑, BioAv↓, BioAv↑, Half-Life↓, toxicity↓, Dose↑, BioAv↑, ChemoSen↑,
2776- Bos,    Anti-inflammatory and anti-cancer activities of frankincense: Targets, treatments and toxicities
- Review, Var, NA
*5LO↓, *TNF-α↓, *MMP3↓, *COX1↓, *COX2↓, *PGE2↓, *Th2↑, *Catalase↑, *SOD↑, *NO↑, *PGE2↑, *IL1β↓, *IL6↓, *Th1 response↓, *Th2↑, *iNOS↓, *NO↓, *p‑JNK↓, *p38↓, GutMicro↑, p‑Akt↓, GSK‐3β↓, cycD1/CCND1↓, Akt↓, STAT3↓, CSCs↓, AR↓, P21↑, DR5↑, CHOP↑, Casp3↑, Casp8↑, cl‑PARP↑, DNAdam↑, p‑RB1↓, FOXM1↓, TOP2↓, CDC25↓, p‑CDK1↓, p‑ERK↓, MMP9↓, VEGF↓, angioG↓, ROS↑, Cyt‑c↑, AIF↑, Diablo↑, survivin↓, ICAD↓, ChemoSen↑, SOX9↓, ER Stress↑, GRP78/BiP↑, cal2↓, AMPK↓, mTOR↓, ROS↓,
2814- CUR,    Curcumin in Cancer and Inflammation: An In-Depth Exploration of Molecular Interactions, Therapeutic Potentials, and the Role in Disease Management
- Review, Var, NA
*BioAv↓, *Inflam↓, *antiOx↑, AntiCan↑, CK2↓, GSK‐3β↓, EGFR↓, TOP1↓, TOP2↓, NF-kB↓, COX2↓, CRP↓,
2813- CUR,    Oxidative Metabolites of Curcumin Poison Human Type II Topoisomerases
- Review, NA, NA
TOP2↑,
2812- CUR,    Curcumin Induces High Levels of Topoisomerase I− and II−DNA Complexes in K562 Leukemia Cells
- in-vitro, AML, K562
TOP1↑, TOP2↑, eff↓,
3239- EGCG,    (−)-Epigallocatechin Gallate, A Major Constituent of Green Tea, Poisons Human Type II Topoisomerases
*TOP2↑,
3240- EGCG,    Green tea constituents (−)-epigallocatechin-3-gallate (EGCG) and gallic acid induce topoisomerase I– and topoisomerase II–DNA complexes in cells mediated by pyrogallol-induced hydrogen peroxide
- in-vitro, AML, K562
TOP1↑, TOP2↑,
2832- FIS,    Fisetin's Promising Antitumor Effects: Uncovering Mechanisms and Targeting for Future Therapies
- Review, Var, NA
MMP↓, mtDam↑, Cyt‑c↑, Diablo↑, Casp↑, cl‑PARP↑, Bak↑, BIM↑, Bcl-xL↓, Bcl-2↓, P53↑, ROS↑, AMPK↑, Casp9↑, Casp3↑, BID↑, AIF↑, Akt↓, mTOR↓, MAPK↓, Wnt↓, β-catenin/ZEB1↓, TumCCA↑, P21↑, p27↑, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4↓, CDK6↓, TumMeta↓, uPA↓, E-cadherin↑, Vim↓, EMT↓, Twist↓, DNAdam↑, ROS↓, COX2↓, PGE2↓, HSF1↓, cFos↓, cJun↓, AP-1↓, Mcl-1↓, NF-kB↓, IRE1↑, ER Stress↑, ATF4↑, GRP78/BiP↑, MMP2↓, MMP9↓, TCF-4↓, MMP7↓, RadioS↑, TOP1↓, TOP2↓,
2997- GEN,    Genistein Inhibition of Topoisomerase IIα Expression Participated by Sp1 and Sp3 in HeLa Cell
- in-vitro, Cerv, HeLa
TOP2↓, Sp1/3/4↓, Apoptosis↑, TumCCA↑,
2906- LT,    Luteolin, a flavonoid with potentials for cancer prevention and therapy
- Review, Var, NA
*Inflam↓, AntiCan↑, antiOx⇅, Apoptosis↑, TumCP↓, TumMeta↓, angioG↓, PI3K↓, Akt↓, NF-kB↓, XIAP↓, P53↑, *ROS↓, *GSTA1↑, *GSR↑, *SOD↑, *Catalase↑, *other↓, ROS↑, Dose↝, chemoP↑, NF-kB↓, JNK↑, p27↑, P21↑, DR5↑, Casp↑, Fas↑, BAX↑, MAPK↓, CDK2↓, IGF-1↓, PDGF↓, EGFR↓, PKCδ↓, TOP1↓, TOP2↓, Bcl-xL↓, FASN↓, VEGF↓, VEGFR2↓, MMP9↓, Hif1a↓, FAK↓, MMP1↓, Twist↓, ERK↓, P450↓, CYP1A1↓, CYP1A2↓, TumCCA↑,
2948- PL,    The promising potential of piperlongumine as an emerging therapeutics for cancer
- Review, Var, NA
tumCV↓, TumCP↓, TumCI↓, angioG↓, EMT↓, TumMeta↓, *hepatoP↑, *lipid-P↓, *GSH↑, cardioP↑, CycB/CCNB1↓, cycD1/CCND1↓, CDK2↓, CDK1↓, CDK4↓, CDK6↓, PCNA↓, Akt↓, mTOR↓, Glycolysis↓, NF-kB↓, IKKα↓, JAK1↓, JAK2↓, STAT3↓, ERK↓, cFos↓, Slug↓, E-cadherin↑, TOP2↓, P53↑, P21↑, Bcl-2↓, BAX↑, Casp3↑, Casp7↑, Casp8↑, p‑HER2/EBBR2↓, HO-1↑, NRF2↑, BIM↑, p‑FOXO3↓, Sp1/3/4↓, cMyc↓, EGFR↓, survivin↓, cMET↓, NQO1↑, SOD2↑, TrxR↓, MDM2↓, p‑eIF2α↑, ATF4↑, CHOP↑, MDA↑, Ki-67↓, MMP9↓, Twist↓, SOX2↓, Nanog↓, OCT4↓, N-cadherin↓, Vim↓, Snail↓, TumW↓, TumCG↓, HK2↓, RB1↓, IL6↓, IL8↓, SOD1↑, RadioS↑, ChemoSen↑, toxicity↓, Sp1/3/4↓, GSH↓, SOD↑,
3355- QC,    Quercetin exhibits cytotoxicity in cancer cells by inducing two-ended DNA double-strand breaks
- in-vitro, Cerv, HeLa
DNAdam↑, ROS↑, *antiOx↑, TOP2↓, γH2AX↑,
3343- QC,    Quercetin, a Flavonoid with Great Pharmacological Capacity
- Review, Var, NA - Review, AD, NA - Review, Arthritis, NA
*antiOx↑, *ROS↓, *angioG↓, *Inflam↓, *BioAv↓, *Half-Life↑, *GSH↑, *SOD↑, *Catalase↑, *Nrf1↑, *BP↓, *cardioP↑, *IL10↓, *TNF-α↓, *Aβ↓, *GSK‐3β↓, *tau↓, *neuroP↑, *Pain↓, *COX2↓, *NRF2↑, *HO-1↑, *IL1β↓, *IL17↓, *MCP1↓, PKCδ↓, ERK↓, BAX↓, cMyc↓, KRAS↓, ROS↓, selectivity↑, tumCV↓, Apoptosis↑, TumCCA↑, eff↑, P-gp↓, eff↑, eff↑, eff↑, eff↑, CycB/CCNB1↓, CDK1↓, CDK4↓, CDK2↓, TOP2↓, Cyt‑c↑, cl‑PARP↑, MMP↓, HSP70/HSPA5↓, HSP90↓, MDM2↓, RAS↓, eff↑,
2687- RES,    Effects of resveratrol, curcumin, berberine and other nutraceuticals on aging, cancer development, cancer stem cells and microRNAs
- Review, NA, NA - Review, AD, NA
NF-kB↓, P450↓, COX2↓, Hif1a↓, VEGF↓, *SIRT1↑, SIRT1↓, SIRT2↓, ChemoSen⇅, cardioP↑, *memory↑, *angioG↑, *neuroP↑, STAT3↓, CSCs↓, RadioS↑, Nestin↓, Nanog↓, TP53↑, P21↑, CXCR4↓, *BioAv↓, EMT↓, Vim↓, Slug↓, E-cadherin↑, AMPK↑, MDR1↓, DNAdam↑, TOP2↓, PTEN↑, Akt↓, Wnt↓, β-catenin/ZEB1↓, cMyc↓, MMP7↓, MALAT1↓, TCF↓, ALDH↓, CD44↓, Shh↓, IL6↓, VEGF↓, eff↑, HK2↓, ROS↑, MMP↓,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 16

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned ⓘ

chemoPv↑, 1,  

Redox & Oxidative Stress ⓘ

antiOx⇅, 1,   CYP1A1↓, 1,   GSH↓, 1,   HO-1↑, 1,   lipid-P?, 1,   MDA↑, 1,   NQO1↑, 1,   NRF2↑, 1,   p‑NRF2↓, 1,   ROS↓, 3,   ROS↑, 6,   i-ROS↑, 1,   SOD↑, 1,   SOD1↑, 1,   SOD2↑, 1,   TrxR↓, 2,  

Metal & Cofactor Biology ⓘ

Tf↓, 1,  

Mitochondria & Bioenergetics ⓘ

ADP:ATP↑, 1,   AIF↑, 2,   CDC25↓, 2,   MMP↓, 4,   mtDam↑, 1,   Raf↓, 1,   XIAP↓, 2,  

Core Metabolism/Glycolysis ⓘ

AMPK↓, 1,   AMPK↑, 2,   cMyc↓, 5,   FASN↓, 1,   Glycolysis↓, 2,   HK2↓, 3,   LDHA↓, 1,   PDK1↓, 1,   PPARα↓, 1,   PPARγ↓, 1,   SIRT1↓, 1,   SIRT2↓, 1,  

Cell Death ⓘ

Akt↓, 6,   p‑Akt↓, 2,   Apoptosis↑, 3,   ASK1↑, 1,   Bak↑, 1,   BAX↓, 1,   BAX↑, 4,   Bcl-2↓, 3,   Bcl-xL↓, 2,   BID↑, 1,   BIM↑, 2,   Casp↑, 2,   Casp3↓, 1,   Casp3↑, 5,   Casp7↑, 1,   Casp8↑, 4,   Casp9↑, 3,   CK2↓, 1,   Cyt‑c↑, 4,   Diablo↑, 2,   DR4↑, 1,   DR5↑, 3,   Fas↑, 1,   ICAD↓, 1,   JNK↓, 1,   JNK↑, 1,   MAPK↓, 2,   Mcl-1↓, 1,   MDM2↓, 3,   p27↑, 3,   survivin↓, 3,  

Kinase & Signal Transduction ⓘ

p‑HER2/EBBR2↓, 1,   SOX9↓, 1,   Sp1/3/4↓, 3,  

Transcription & Epigenetics ⓘ

cJun↓, 1,   tumCV↓, 2,  

Protein Folding & ER Stress ⓘ

CHOP↑, 2,   p‑eIF2α↑, 1,   ER Stress↓, 1,   ER Stress↑, 2,   GRP78/BiP↑, 3,   HSF1↓, 1,   HSP70/HSPA5↓, 1,   HSP90↓, 1,   IRE1↑, 1,  

DNA Damage & Repair ⓘ

DNAdam↑, 5,   P53↑, 3,   cl‑PARP↑, 4,   PCNA↓, 2,   TP53↑, 1,   γH2AX↑, 1,  

Cell Cycle & Senescence ⓘ

CDK1↓, 2,   p‑CDK1↓, 1,   CDK2↓, 6,   CDK4↓, 5,   CycB/CCNB1↓, 3,   cycD1/CCND1↓, 5,   cycE/CCNE↓, 3,   E2Fs↓, 1,   P21↑, 6,   RB1↓, 1,   p‑RB1↓, 2,   TumCCA↑, 5,  

Proliferation, Differentiation & Cell State ⓘ

ALDH↓, 1,   CD44↓, 1,   cFos↓, 2,   cMET↓, 1,   CSCs↓, 2,   EMT↓, 3,   ERK↓, 4,   p‑ERK↓, 2,   FOXM1↓, 1,   p‑FOXO3↓, 1,   Gli1↓, 1,   GSK‐3β↓, 2,   IGF-1↓, 1,   Let-7↑, 1,   mTOR↓, 3,   p‑mTOR↓, 1,   Nanog↓, 2,   Nestin↓, 1,   NOTCH↓, 1,   OCT4↓, 2,   PI3K↓, 1,   PTEN↑, 2,   RAS↓, 1,   Shh↓, 2,   Smo↓, 1,   SOX2↓, 2,   STAT3↓, 5,   TCF↓, 1,   TCF-4↓, 1,   TOP1↓, 4,   TOP1↑, 2,   TOP2↓, 11,   TOP2↑, 4,   TumCG↓, 1,   Wnt↓, 4,  

Migration ⓘ

AP-1↓, 2,   Ca+2↑, 1,   cal2↓, 1,   Cdc42↑, 1,   E-cadherin↑, 6,   FAK↓, 1,   Ki-67↓, 1,   KRAS↓, 1,   MALAT1↓, 1,   miR-200b↑, 1,   MMP1↓, 2,   MMP2↓, 5,   MMP7↓, 3,   MMP9↓, 8,   N-cadherin↓, 2,   PDGF↓, 2,   PKCδ↓, 3,   Slug↓, 2,   Snail↓, 2,   TIMP1↓, 1,   TIMP2↓, 1,   TIMP2↑, 1,   TumCI↓, 2,   TumCP↓, 3,   TumMeta↓, 4,   Twist↓, 3,   uPA↓, 3,   Vim↓, 5,   ZO-1↑, 1,   β-catenin/ZEB1↓, 4,  

Angiogenesis & Vasculature ⓘ

angioG↓, 5,   ATF4↑, 2,   EGFR↓, 3,   Hif1a↓, 3,   p‑PDGFR-BB↓, 1,   VEGF↓, 8,   VEGFR2↓, 2,  

Barriers & Transport ⓘ

P-gp↓, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 5,   CRP↓, 1,   CXCR4↓, 2,   IKKα↓, 2,   IL1α↓, 1,   IL6↓, 3,   IL8↓, 2,   JAK1↓, 1,   JAK2↓, 1,   MCP1↓, 1,   MIP2↓, 1,   NF-kB↓, 9,   PGE2↓, 1,  

Synaptic & Neurotransmission ⓘ

5HT↓, 1,  

Hormonal & Nuclear Receptors ⓘ

AR↓, 2,   CDK6↓, 2,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 2,   BioAv↑, 3,   ChemoSen↑, 3,   ChemoSen⇅, 1,   CYP1A2↓, 1,   Dose↑, 1,   Dose↝, 1,   eff↓, 2,   eff↑, 12,   Half-Life↓, 2,   MDR1↓, 1,   P450↓, 2,   RadioS↑, 3,   selectivity↑, 2,  

Clinical Biomarkers ⓘ

AR↓, 2,   ascitic↓, 1,   CRP↓, 1,   EGFR↓, 3,   FOXM1↓, 1,   GutMicro↑, 1,   p‑HER2/EBBR2↓, 1,   IL6↓, 3,   Ki-67↓, 1,   KRAS↓, 1,   TP53↑, 1,  

Functional Outcomes ⓘ

AntiCan↑, 3,   cardioP↑, 2,   chemoP↑, 1,   toxicity↓, 2,   TumVol↓, 1,   TumW↓, 1,  
Total Targets: 220

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 3,   Catalase↑, 3,   GSH↑, 2,   GSR↑, 1,   GSTA1↑, 1,   HO-1↑, 1,   lipid-P↓, 1,   Nrf1↑, 1,   NRF2↑, 1,   ROS↓, 2,   SOD↑, 3,  

Core Metabolism/Glycolysis ⓘ

SIRT1↑, 1,  

Cell Death ⓘ

iNOS↓, 1,   p‑JNK↓, 1,   MAPK↑, 1,   p38↓, 1,  

Transcription & Epigenetics ⓘ

other↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

GSK‐3β↓, 1,   TOP2↑, 1,  

Migration ⓘ

5LO↓, 1,   Ca+2↝, 1,   MMP3↓, 1,  

Angiogenesis & Vasculature ⓘ

angioG↓, 1,   angioG↑, 1,   NO↓, 1,   NO↑, 1,  

Immune & Inflammatory Signaling ⓘ

COX1↓, 1,   COX2↓, 2,   IL10↓, 1,   IL17↓, 1,   IL1β↓, 2,   IL6↓, 1,   Inflam↓, 4,   MCP1↓, 1,   NF-kB↓, 1,   PGE2↓, 1,   PGE2↑, 1,   Th1 response↓, 1,   Th2↑, 2,   TNF-α↓, 3,  

Synaptic & Neurotransmission ⓘ

tau↓, 1,  

Protein Aggregation ⓘ

Aβ↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 3,   Half-Life↑, 1,  

Clinical Biomarkers ⓘ

BP↓, 1,   IL6↓, 1,  

Functional Outcomes ⓘ

cardioP↑, 1,   hepatoP↑, 1,   memory↑, 1,   neuroP↑, 2,   Pain↓, 1,  
Total Targets: 51

Scientific Paper Hit Count for: TOP2, Topoisomerase II
3 Curcumin
2 Boswellia (frankincense)
2 EGCG (Epigallocatechin Gallate)
2 Quercetin
1 Artemisinin
1 Baicalein
1 Fisetin
1 Genistein (soy isoflavone)
1 Luteolin
1 Piperlongumine
1 Resveratrol
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1321  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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