Database Query Results : , , uricA

uricA, uric acid: Click to Expand ⟱
Source:
Type:
Uric acid is a bit of a double-edged sword when it comes to oxidative stress:

Antioxidant Effects:
-Uric acid is considered one of the most important antioxidants in human plasma. It can scavenge reactive oxygen species (ROS) such as singlet oxygen and peroxyl radicals.
-Its antioxidant properties help protect cells and tissues from oxidative damage, contributing to the overall antioxidant capacity of the blood.

Pro-oxidant Effects:
-Under certain conditions, especially at high concentrations, uric acid can also act as a pro-oxidant. For example, it may promote inflammation and oxidative stress in vascular tissues, which has been associated with conditions like hypertension and cardiovascular disease.
-The formation of monosodium urate crystals (as seen in gout) is linked to inflammatory reactions, and these crystals can contribute to local oxidative stress.

-Some studies have reported that elevated serum uric acid levels can be found in patients with certain cancers, possibly reflecting high cell turnover or altered metabolism. In some cases, higher local concentrations of uric acid might contribute to the antioxidant environment or even affect inflammatory processes.
Scientific Papers found: Click to Expand⟱
3170- Ash,    Withaferin A protects against hyperuricemia induced kidney injury and its possible mechanisms
- in-vitro, Nor, NRK52E - in-vivo, NA, NA
*RenoP↑, *hepatoP↑, *creat↓, *BUN↓, *uricA↓, *Apoptosis↓, *α-SMA↓,
2630- Ba,    Baicalein decreases uric acid and prevents hyperuricemic nephropathy in mice
- in-vivo, Nor, NA
*RenoP↑, *uricA↓, *ROS↓, EMT↓,
4022- FulvicA,  Chemo,    Shilajit potentiates the effect of chemotherapeutic drugs and mitigates metastasis induced liver and kidney damages in osteosarcoma rats
- in-vivo, OS, NA
AST↓, ALAT↓, ALP↓, Bil↝, creat↓, uricA↓, ChemoSen↑, chemoP↑,
3847- MSM,    Methylsulfonylmethane: Applications and Safety of a Novel Dietary Supplement
- Review, Arthritis, NA
*Inflam↓, *Pain↓, *ROS↓, *antiOx↑, *Dose↝, *Half-Life↝, *NF-kB↓, *IL1↓, *IL6↓, *TNF-α↓, *iNOS↓, *COX2↓, *NLRP3↓, *NRF2↑, *STAT↓, *Cartilage↑, *eff↑, *eff↑, *GSH↑, *uricA↓, tumCV↓, TumCCA↑, necrosis↑, Apoptosis↑, VEGF↓, HSP90↓, IGF-1?,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 4

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

Bil↝, 1,   uricA↓, 1,  

Core Metabolism/Glycolysis ⓘ

ALAT↓, 1,  

Cell Death ⓘ

Apoptosis↑, 1,   necrosis↑, 1,  

Transcription & Epigenetics ⓘ

tumCV↓, 1,  

Protein Folding & ER Stress ⓘ

HSP90↓, 1,  

Cell Cycle & Senescence ⓘ

TumCCA↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

EMT↓, 1,   IGF-1?, 1,  

Angiogenesis & Vasculature ⓘ

VEGF↓, 1,  

Drug Metabolism & Resistance ⓘ

ChemoSen↑, 1,  

Clinical Biomarkers ⓘ

ALAT↓, 1,   ALP↓, 1,   AST↓, 1,   Bil↝, 1,   creat↓, 1,  

Functional Outcomes ⓘ

chemoP↑, 1,  
Total Targets: 18

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 1,   GSH↑, 1,   NRF2↑, 1,   ROS↓, 2,   uricA↓, 3,  

Core Metabolism/Glycolysis ⓘ

BUN↓, 1,  

Cell Death ⓘ

Apoptosis↓, 1,   iNOS↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

STAT↓, 1,  

Migration ⓘ

Cartilage↑, 1,   α-SMA↓, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 1,   IL1↓, 1,   IL6↓, 1,   Inflam↓, 1,   NF-kB↓, 1,   TNF-α↓, 1,  

Protein Aggregation ⓘ

NLRP3↓, 1,  

Drug Metabolism & Resistance ⓘ

Dose↝, 1,   eff↑, 2,   Half-Life↝, 1,  

Clinical Biomarkers ⓘ

creat↓, 1,   IL6↓, 1,  

Functional Outcomes ⓘ

hepatoP↑, 1,   Pain↓, 1,   RenoP↑, 2,  
Total Targets: 26

Scientific Paper Hit Count for: uricA, uric acid
1 Ashwagandha(Withaferin A)
1 Baicalein
1 Shilajit/Fulvic Acid
1 Chemotherapy
1 Methylsulfonylmethane
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1322  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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