Database Query Results : , , AQPs

AQPs, Aquaporins: Click to Expand ⟱
Source:
Type:
Aquaporins are membrane proteins that form channels to facilitate water transport across cell membranes. They are essential for maintaining water homeostasis in various tissues, and research over the past decade has revealed their involvement in several aspects of cancer biology.
• Aquaporins can influence cell proliferation. Some studies have shown that overexpression of specific aquaporin isoforms (like AQP1, AQP3, and AQP5) is associated with increased cell proliferation in different cancer types.
-increased expression of AQP1 or AQP3 has been correlated with poor prognosis in some cancers.
Scientific Papers found: Click to Expand⟱
3882- Api,    Enhancing Amyloid-β Clearance May Improve Brain Function in Alzheimer Disease
- Review, AD, NA
*AQPs↑, *Aβ↓,
3883- Api,    New approach to clearing toxic waste from brain
- Review, AD, NA
*AQPs↓,
2682- BBR,    Berberine Inhibited Growth and Migration of Human Colon Cancer Cell Lines by Increasing Phosphatase and Tensin and Inhibiting Aquaporins 1, 3 and 5 Expressions
- in-vitro, CRC, HT29 - in-vitro, CRC, SW480 - in-vitro, CRC, HCT116
TumCP↓, TumCMig↓, TumCI↓, Apoptosis↑, necrosis↑, AQPs↓, PTEN↑, PI3K↓, Akt↓, p‑Akt↓, mTOR↓, p‑mTOR↓,
3709- dietSTF,    Intermittent Fasting Protects against Alzheimer’s Disease Possible through Restoring Aquaporin-4 Polarity
- in-vitro, AD, NA
*cognitive↑, *Aβ↓, *AQPs↓, *HDAC3↓,
3182- SFN,    Sulforaphane Modulates AQP8-Linked Redox Signalling in Leukemia Cells
- in-vitro, AML, NA
Prx↓, AQPs↓, NOX↓, tumCV↓, AntiCan↑, cardioP↑, neuroP↑, Inflam↓, chemoPv↑, angioG↓, TumMeta↓, selectivity↑, ROS↓,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 5

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned ⓘ

chemoPv↑, 1,  

Redox & Oxidative Stress ⓘ

Prx↓, 1,   ROS↓, 1,  

Cell Death ⓘ

Akt↓, 1,   p‑Akt↓, 1,   Apoptosis↑, 1,   necrosis↑, 1,  

Transcription & Epigenetics ⓘ

tumCV↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

mTOR↓, 1,   p‑mTOR↓, 1,   PI3K↓, 1,   PTEN↑, 1,  

Migration ⓘ

TumCI↓, 1,   TumCMig↓, 1,   TumCP↓, 1,   TumMeta↓, 1,  

Angiogenesis & Vasculature ⓘ

angioG↓, 1,  

Barriers & Transport ⓘ

AQPs↓, 2,  

Immune & Inflammatory Signaling ⓘ

Inflam↓, 1,  

Cellular Microenvironment ⓘ

NOX↓, 1,  

Drug Metabolism & Resistance ⓘ

selectivity↑, 1,  

Functional Outcomes ⓘ

AntiCan↑, 1,   cardioP↑, 1,   neuroP↑, 1,  
Total Targets: 24

Pathway results for Effect on Normal Cells:


Proliferation, Differentiation & Cell State ⓘ

HDAC3↓, 1,  

Barriers & Transport ⓘ

AQPs↓, 2,   AQPs↑, 1,  

Protein Aggregation ⓘ

Aβ↓, 2,  

Functional Outcomes ⓘ

cognitive↑, 1,  
Total Targets: 5

Scientific Paper Hit Count for: AQPs, Aquaporins
2 Apigenin (mainly Parsley)
1 Berberine
1 diet Short Term Fasting
1 Sulforaphane (mainly Broccoli)
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1324  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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