Database Query Results : , , GPx1

GPx1, Glutathione Peroxidase: Click to Expand ⟱
Source:
Type:
Widely and abundantly expressed antioxidant enzyme
Glutathione peroxidase (GPx) is an important antioxidant enzyme that plays a crucial role in protecting cells from oxidative stress by catalyzing the reduction of hydrogen peroxide and organic peroxides. It utilizes glutathione, a tripeptide composed of glutamine, cysteine, and glycine, as a substrate to carry GPx is part of the body's antioxidant defense system. By reducing oxidative stress, GPx may help prevent the initiation and progression of cancer. Some studies suggest that higher levels of GPx activity are associated with a lower risk of certain cancers.
The tumor microenvironment is often characterized by increased oxidative stress. GPx can influence the behavior of cancer cells and their interactions with surrounding cells. In some cases, cancer cells may upregulate GPx to survive in this oxidative environment, which can contribute to tumor growth and resistance Inhibiting GPx in certain cancer types may sensitize tumor cells to chemotherapy and radiation therapy by increasing oxidative stress.to therapy.

GPX1 is widely expressed in various tissues and is particularly important in maintaining cellular redox balance. GPX1 expression is often elevated in various cancers and is generally associated with poorer prognosis due to its role in protecting cancer cells from oxidative stress and contributing to treatment resistance.


Scientific Papers found: Click to Expand⟱
2612- Ba,  MF,    The effect of a static magnetic field and baicalin or baicalein interactions on amelanotic melanoma cell cultures (C32)
- in-vitro, Melanoma, NA
SOD1↑, SOD2↑, GPx1↑, Dose?, eff↝, SOD1↓, SOD2↓, GPx1↓,
448- CUR,    Heat shock protein 27 influences the anti-cancer effect of curcumin in colon cancer cells through ROS production and autophagy activation
- in-vitro, CRC, HT-29
Apoptosis↑, TumCCA↑, p‑Akt↓, Akt↓, Bcl-2↓, p‑BAD↓, BAD↑, cl‑PARP↑, ROS↑, HSP27↑, Beclin-1↑, p62↑, GPx1↓, GPx4↓,
3770- H2,    Role of Molecular Hydrogen in Ageing and Ageing-Related Diseases
- Review, AD, NA - Review, Park, NA
*antiOx↑, *NRF2↑, *HO-1↑, *Inflam↓, *neuroP↑, *cardioP↑, *other↓, *ROS↓, *NADPH↓, *Catalase↑, *GPx1↑, *NO↓, *mt-ROS↓, *SIRT3↑, *SIRT1↑, *TLR4↓, *mTOR↓, *cognitive↑, *Sepsis↓, *PTEN↓, *Akt↓, *NLRP3↓, *AntiAg↑, *IL6↓, *TNF-α↓, *IL1β↓, *MDA↓, *memory↑, *FOXO3↑, TumCG↓, *LDL↓,
2249- MF,    Pulsed electromagnetic fields modulate energy metabolism during wound healing process: an in vitro model study
- in-vitro, Nor, L929
*TumCMig↑, *tumCV↑, *Glycolysis↑, *ROS↓, *mitResp↓, *other↝, *OXPHOS↓, *pH↑, *antiOx↑, *PFKM↑, *PFKL↑, *PKM2↑, *HK2↑, *GLUT1↑, *GPx1↑, *GPx4↑, *SOD1↑,
3457- MF,    Cellular stress response to extremely low‐frequency electromagnetic fields (ELF‐EMF): An explanation for controversial effects of ELF‐EMF on apoptosis
- Review, Var, NA
Apoptosis↑, H2O2↑, ROS↑, eff↑, eff↑, Ca+2↑, MAPK↑, *Catalase↑, *SOD1↑, *GPx1↑, *GPx4↑, *NRF2↑, TumAuto↑, ER Stress↑, HSPs↑, SIRT3↑, ChemoSen↑, UPR↑, other↑, PI3K↓, JNK↑, p38↑, eff↓, *toxicity?,
4102- MF,    Modulation of antioxidant enzyme gene expression by extremely low frequency electromagnetic field in post-stroke patients
- Human, Stroke, NA
*Catalase↑, *SOD1↑, *SOD2↑, *GPx1↑, *GPx4↑, *Dose↝,
525- MF,    Pulsed electromagnetic fields regulate metabolic reprogramming and mitochondrial fission in endothelial cells for angiogenesis
- in-vitro, Nor, HUVECs
*angioG↑, *GPx1↑, *GPx4↑, *SOD↑, *PFKM↑, *PFKL↑, *PKM2↑, *PFKP↑, *HK2↑, *GLUT1↑, *GLUT4↑, *ROS↓, *MMP↝, *Glycolysis↑, *OXPHOS↓,
3567- MFrot,  MF,    The Effect of Extremely Low-Frequency Magnetic Field on Stroke Patients: A Systematic Review
- Review, Stroke, NA
*eff↑, *ROS↓, *Inflam↓, *cognitive↑, *Catalase↑, *SOD↑, *SOD1↑, *SOD2↑, *GPx1↑, *GPx4↑, *IL1β↑, *neuroP↑, *toxicity∅,
1988- Part,    Parthenolide Induces ROS-Mediated Apoptosis in Lymphoid Malignancies
- in-vitro, lymphoma, NCI-H929
NF-kB↓, ROS↑, GSH↓, MMP↓, GPx1↓,
4922- PEITC,    Phenethyl Isothiocyanate: A comprehensive review of anti-cancer mechanisms
- Review, Var, NA
Risk↓, AntiCan↑, TumCP↓, TumMeta↓, ChemoSen↑, *BioAv↑, *other↝, *Dose↝, Dose↓, *BioAv↑, *Dose↝, *Half-Life↝, *toxicity↝, GSH↓, ROS↑, CYP1A1↑, CYP1A2↑, P450↓, CYP2E1↑, CYP3A4↓, CYP2A3/CYP2A6↓, *ROS↓, *GPx1↑, *SOD1↑, *SOD2↑, Akt↓, EGFR↓, HER2/EBBR2↓, P53↑, Telomerase↓, selectivity↑, MMP↓, Cyt‑c↑, Apoptosis↑, DR4↑, Fas↑, XIAP↓, survivin↓, TumAuto↑, Hif1a↓, angioG↓, MMPs↓, ERK↓, NF-kB↓, EMT↓, TumCI↓, TumCMig↓, Glycolysis↓, ATP↓, selectivity↑, *antiOx↑, Dose↝, other↝, OCR↓, GSH↓, ITGB1↓, ITGB6↓, ChemoSen↑,
2969- PL,    Piperlongumine induces autophagy by targeting p38 signaling
- in-vitro, OS, U2OS - in-vitro, Cerv, HeLa
p38↑, ROS↑, GPx1∅, SOD∅, Catalase∅,
4613- Se,  Rad,    Effect of Selenium and Selenoproteins on Radiation Resistance
- Review, Nor, NA
*selenoP↑, *GPx1↑, *GPx4↑, *lipid-P↓, *DNAdam↓, *ROS↓, *radioP↑,
4610- Se,  Rad,    Protection during radiotherapy: selenium
- Review, Var, NA
*radioP↑, *antiOx↑, *Inflam↓, *DNAdam↓, *lipid-P↓, *selenoP↑, *GPx1↑, *BUN↓,
4729- Se,    Selenium regulates Nrf2 signaling to prevent hepatotoxicity induced by hexavalent chromium in broilers
*ROS↓, *NRF2↑, *GPx1↑, *NQO1↑, *mTOR↑, *Beclin-1↓, *ATG5↓, *LC3s↓, *hepatoP↑,
3399- TQ,    Anticancer Effects of Thymoquinone through the Antioxidant Activity, Upregulation of Nrf2, and Downregulation of PD-L1 in Triple-Negative Breast Cancer Cells
- in-vitro, BC, MDA-MB-231 - NA, BC, MDA-MB-468
ROS↓, H2O2↓, Catalase↑, SOD↑, GSH↑, NQO1↑, GCLM↑, NRF2↑, PD-L1↓, GSSG↑, GPx1⇅, GPx4↓,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 15

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

Catalase↑, 1,   Catalase∅, 1,   CYP1A1↑, 1,   CYP2E1↑, 1,   GCLM↑, 1,   GPx1↓, 3,   GPx1↑, 1,   GPx1⇅, 1,   GPx1∅, 1,   GPx4↓, 2,   GSH↓, 3,   GSH↑, 1,   GSSG↑, 1,   H2O2↓, 1,   H2O2↑, 1,   NQO1↑, 1,   NRF2↑, 1,   ROS↓, 1,   ROS↑, 5,   SIRT3↑, 1,   SOD↑, 1,   SOD∅, 1,   SOD1↓, 1,   SOD1↑, 1,   SOD2↓, 1,   SOD2↑, 1,  

Mitochondria & Bioenergetics ⓘ

ATP↓, 1,   MMP↓, 2,   OCR↓, 1,   XIAP↓, 1,  

Core Metabolism/Glycolysis ⓘ

CYP3A4↓, 1,   Glycolysis↓, 1,  

Cell Death ⓘ

Akt↓, 2,   p‑Akt↓, 1,   Apoptosis↑, 3,   BAD↑, 1,   p‑BAD↓, 1,   Bcl-2↓, 1,   Cyt‑c↑, 1,   DR4↑, 1,   Fas↑, 1,   JNK↑, 1,   MAPK↑, 1,   p38↑, 2,   survivin↓, 1,   Telomerase↓, 1,  

Kinase & Signal Transduction ⓘ

HER2/EBBR2↓, 1,  

Transcription & Epigenetics ⓘ

other↑, 1,   other↝, 1,  

Protein Folding & ER Stress ⓘ

ER Stress↑, 1,   HSP27↑, 1,   HSPs↑, 1,   UPR↑, 1,  

Autophagy & Lysosomes ⓘ

Beclin-1↑, 1,   p62↑, 1,   TumAuto↑, 2,  

DNA Damage & Repair ⓘ

P53↑, 1,   cl‑PARP↑, 1,  

Cell Cycle & Senescence ⓘ

TumCCA↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

EMT↓, 1,   ERK↓, 1,   PI3K↓, 1,   TumCG↓, 1,  

Migration ⓘ

Ca+2↑, 1,   ITGB1↓, 1,   ITGB6↓, 1,   MMPs↓, 1,   TumCI↓, 1,   TumCMig↓, 1,   TumCP↓, 1,   TumMeta↓, 1,  

Angiogenesis & Vasculature ⓘ

angioG↓, 1,   EGFR↓, 1,   Hif1a↓, 1,  

Immune & Inflammatory Signaling ⓘ

NF-kB↓, 2,   PD-L1↓, 1,  

Drug Metabolism & Resistance ⓘ

ChemoSen↑, 3,   CYP1A2↑, 1,   CYP2A3/CYP2A6↓, 1,   Dose?, 1,   Dose↓, 1,   Dose↝, 1,   eff↓, 1,   eff↑, 2,   eff↝, 1,   P450↓, 1,   selectivity↑, 2,  

Clinical Biomarkers ⓘ

EGFR↓, 1,   HER2/EBBR2↓, 1,   PD-L1↓, 1,  

Functional Outcomes ⓘ

AntiCan↑, 1,   Risk↓, 1,  
Total Targets: 92

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 4,   Catalase↑, 4,   GPx1↑, 10,   GPx4↑, 6,   HO-1↑, 1,   lipid-P↓, 2,   MDA↓, 1,   NQO1↑, 1,   NRF2↑, 3,   OXPHOS↓, 2,   ROS↓, 7,   mt-ROS↓, 1,   selenoP↑, 2,   SIRT3↑, 1,   SOD↑, 2,   SOD1↑, 5,   SOD2↑, 3,  

Mitochondria & Bioenergetics ⓘ

mitResp↓, 1,   MMP↝, 1,  

Core Metabolism/Glycolysis ⓘ

BUN↓, 1,   Glycolysis↑, 2,   HK2↑, 2,   LDL↓, 1,   NADPH↓, 1,   PFKL↑, 2,   PFKM↑, 2,   PFKP↑, 1,   PKM2↑, 2,   SIRT1↑, 1,  

Cell Death ⓘ

Akt↓, 1,  

Transcription & Epigenetics ⓘ

other↓, 1,   other↝, 2,   tumCV↑, 1,  

Autophagy & Lysosomes ⓘ

ATG5↓, 1,   Beclin-1↓, 1,   LC3s↓, 1,  

DNA Damage & Repair ⓘ

DNAdam↓, 2,  

Proliferation, Differentiation & Cell State ⓘ

FOXO3↑, 1,   mTOR↓, 1,   mTOR↑, 1,   PTEN↓, 1,  

Migration ⓘ

AntiAg↑, 1,   TumCMig↑, 1,  

Angiogenesis & Vasculature ⓘ

angioG↑, 1,   NO↓, 1,  

Barriers & Transport ⓘ

GLUT1↑, 2,   GLUT4↑, 1,  

Immune & Inflammatory Signaling ⓘ

IL1β↓, 1,   IL1β↑, 1,   IL6↓, 1,   Inflam↓, 3,   TLR4↓, 1,   TNF-α↓, 1,  

Cellular Microenvironment ⓘ

pH↑, 1,  

Protein Aggregation ⓘ

NLRP3↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↑, 2,   Dose↝, 3,   eff↑, 1,   Half-Life↝, 1,  

Clinical Biomarkers ⓘ

IL6↓, 1,  

Functional Outcomes ⓘ

cardioP↑, 1,   cognitive↑, 2,   hepatoP↑, 1,   memory↑, 1,   neuroP↑, 2,   radioP↑, 2,   toxicity?, 1,   toxicity↝, 1,   toxicity∅, 1,  

Infection & Microbiome ⓘ

Sepsis↓, 1,  
Total Targets: 70

Scientific Paper Hit Count for: GPx1, Glutathione Peroxidase
6 Magnetic Fields
3 Selenium
2 Radiotherapy/Radiation
1 Baicalein
1 Curcumin
1 Hydrogen Gas
1 Magnetic Field Rotating
1 Parthenolide
1 Phenethyl isothiocyanate
1 Piperlongumine
1 Thymoquinone
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:133  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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