Database Query Results : , , Choline

Choline, Choline: Click to Expand ⟱
Source:
Type:
Choline is an essential nutrient involved in multiple cellular functions including membrane biosynthesis (as part of phosphatidylcholine), methyl group metabolism, and cholinergic neurotransmission.
– Elevated levels of choline-containing compounds, often measured via magnetic resonance spectroscopy (MRS) or positron emission tomography (PET) using radiolabeled choline analogues, are frequently reported.
– High choline uptake or increased levels of choline metabolites generally correlate with higher tumor grade, greater aggressiveness, and poorer overall survival.
Choline is an essential nutrient with four core biological roles:
-Membrane structure – precursor of phosphatidylcholine (PC) and sphingomyelin
-One-carbon metabolism – methyl donor via betaine → methionine → SAM
-Neurotransmission – precursor of acetylcholine
-Lipoprotein export – required for VLDL assembly and hepatic lipid handling

These functions place choline at the intersection of cell proliferation, epigenetic regulation, and neuronal signaling, which explains its relevance to both cancer and neurodegeneration.


Scientific Papers found: Click to Expand⟱
2772- Bos,    Mechanistic role of boswellic acids in Alzheimer’s disease: Emphasis on anti-inflammatory properties
- Review, AD, NA
*neuroP↑, *Inflam↓, *AChE↓, *Choline↑, *NRF2↑, *NF-kB↑, *BBB↑, *BioAv↑, *Half-Life↓, *Dose↝, *PGE2↓, *ROS↓, *cognitive↑, *antiOx↑, 5LO↓, *TNF-α↓, *IL6↓, *HO-1↑,
3917- PS,    Phosphatidylserine, inflammation, and central nervous system diseases
- Review, AD, NA - Review, Park, NA - Review, Stroke, NA
*Inflam↓, *neuroP↑, *cognitive↑, *Choline↑, *IL1β↓, *IL6↓, *TNF-α↓, *Ach↑, *eff↑, *eff↑, *BioEnh↑, other↑,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


Transcription & Epigenetics ⓘ

other↑, 1,  

Migration ⓘ

5LO↓, 1,  
Total Targets: 2

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 1,   HO-1↑, 1,   NRF2↑, 1,   ROS↓, 1,  

Transcription & Epigenetics ⓘ

Ach↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

Choline↑, 2,  

Barriers & Transport ⓘ

BBB↑, 1,  

Immune & Inflammatory Signaling ⓘ

IL1β↓, 1,   IL6↓, 2,   Inflam↓, 2,   NF-kB↑, 1,   PGE2↓, 1,   TNF-α↓, 2,  

Synaptic & Neurotransmission ⓘ

AChE↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↑, 1,   BioEnh↑, 1,   Dose↝, 1,   eff↑, 2,   Half-Life↓, 1,  

Clinical Biomarkers ⓘ

IL6↓, 2,  

Functional Outcomes ⓘ

cognitive↑, 2,   neuroP↑, 2,  
Total Targets: 22

Scientific Paper Hit Count for: Choline, Choline
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1330  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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