Database Query Results : , , HDAC6

HDAC6, HDAC6: Click to Expand ⟱
Source:
Type:
Histone deacetylase 6 (HDAC6) is a cytoplasmic enzyme that plays a significant role in regulating various cellular processes, and its dysregulation has been implicated in cancer pathogenesis and progression.
-HDAC6 primarily deacetylates non-histone proteins, including α-tubulin and heat shock protein 90 (Hsp90).
-Many studies have reported overexpression or hyperactivation of HDAC6 in different cancer types.
Scientific Papers found: Click to Expand⟱
2874- HNK,    Suppressing migration and invasion of H1299 lung cancer cells by honokiol through disrupting expression of an HDAC6‐mediated matrix metalloproteinase 9
- in-vitro, Lung, H1299
MMP9↓, α-tubulin↑, TumCI↓, HDAC6↓, HSP90↓, TumCMig↓, EGFR↓,
2878- HNK,    Suppressing migration and invasion of H1299 lung cancer cells by honokiol through disrupting expression of an HDAC6-mediated matrix metalloproteinase 9
- in-vitro, Lung, H1299
TumCMig↓, TumCI↓, MMP9↓, α-tubulin↑, HDAC6↓, HSP90↓,
3359- QC,    Quercetin modifies 5′CpG promoter methylation and reactivates various tumor suppressor genes by modulating epigenetic marks in human cervical cancer cells
- in-vitro, Cerv, HeLa
DNMTs↓, HDAC↓, HMTs↓, DNMT3A↓, EZH2↓, HDAC1↓, HDAC2↓, HDAC6↓, HDAC11↓, G9a↓, TIMP3↑, PTEN↑, SOCS1↑,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 3

Pathway results for Effect on Cancer / Diseased Cells:


Transcription & Epigenetics ⓘ

EZH2↓, 1,  

Protein Folding & ER Stress ⓘ

HSP90↓, 2,  

DNA Damage & Repair ⓘ

DNMT3A↓, 1,   DNMTs↓, 1,   G9a↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

HDAC↓, 1,   HDAC1↓, 1,   HDAC11↓, 1,   HDAC2↓, 1,   HDAC6↓, 3,   HMTs↓, 1,   PTEN↑, 1,  

Migration ⓘ

MMP9↓, 2,   TIMP3↑, 1,   TumCI↓, 2,   TumCMig↓, 2,   α-tubulin↑, 2,  

Angiogenesis & Vasculature ⓘ

EGFR↓, 1,  

Immune & Inflammatory Signaling ⓘ

SOCS1↑, 1,  

Clinical Biomarkers ⓘ

EGFR↓, 1,   EZH2↓, 1,  
Total Targets: 21

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: HDAC6, HDAC6
2 Honokiol
1 Quercetin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1335  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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