Database Query Results : , , Prx3

Prx3, peroxiredoxin-3: Click to Expand ⟱
Source:
Type:
PRX3 is a mitochondrial antioxidant enzyme that plays a role in scavenging reactive oxygen species (ROS).
-Peroxiredoxin-3 (PRX3) works through a catalytic cycle in which it alternates between reduced and oxidized states to detoxify hydrogen peroxide and other peroxides in the mitochondria.
-In its reduced state, the active-site cysteine of PRX3 is ready to react with peroxide.
-PRX3 is overexpressed in a range of cancers compared with normal tissues.
-Elevated expression is thought to contribute to cancer cell survival under oxidative stress and may play a role in resistance against chemotherapy or radiation, which often act by generating ROS.
Scientific Papers found: Click to Expand⟱
2895- HNK,    Mitochondria-Targeted Honokiol Confers a Striking Inhibitory Effect on Lung Cancer via Inhibiting Complex I Activity
- in-vitro, Lung, PC9
eff↑, TumCP↓, mt-ROS↑, Prx3↑, mt-STAT3↓, *toxicity∅, selectivity↑, ChemoSen↑,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

Prx3↑, 1,   mt-ROS↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

mt-STAT3↓, 1,  

Migration ⓘ

TumCP↓, 1,  

Drug Metabolism & Resistance ⓘ

ChemoSen↑, 1,   eff↑, 1,   selectivity↑, 1,  
Total Targets: 7

Pathway results for Effect on Normal Cells:


Functional Outcomes ⓘ

toxicity∅, 1,  
Total Targets: 1

Scientific Paper Hit Count for: Prx3, peroxiredoxin-3
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1336  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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