Database Query Results : , , GPx3

GPx3, Glutathione Peroxidase 3: Click to Expand ⟱
Source:
Type:
GPX3, or Glutathione Peroxidase 3, is an enzyme that plays a crucial role in protecting cells from oxidative stress by reducing hydrogen peroxide and other peroxides.
Glutathione peroxidase 3 (GPX3) is another member of the glutathione peroxidase family, primarily found in extracellular spaces and secreted into the bloodstream. It plays a crucial role in protecting cells from oxidative stress by reducing hydrogen peroxide and organic peroxides.
GPX3 can act as a tumor suppressor, as its expression is often downregulated in various types of cancer, including breast, prostate, and colorectal cancers. Lower levels of GPX3 may lead to increased oxidative stress, which can promote cancer cell proliferation and survival.
Conversely, in some contexts, GPX3 may also be associated with cancer progression, particularly in the tumor microenvironment, where it can influence the behavior of cancer cells and their interactions with surrounding tissues.

GPX3 expression is often decreased in various cancers and is generally associated with poorer prognosis due to its role in protecting cells from oxidative stress. The downregulation of GPX3 can lead to increased oxidative damage, promoting tumor progression and aggressiveness.


Scientific Papers found: Click to Expand⟱
4111- MF,    Coupling of pulsed electromagnetic fields (PEMF) therapy to molecular grounds of the cell
- Review, Arthritis, NA
*Inflam↓, *Cartilage↑, *Pain↓, *QoL↑, *Dose↝, *VEGF↑, *NO↑, *TGF-β↑, *MMP9↓, *PGE2↑, *GPx3↑, *SOD2↑, *Catalase↑, *GSR↑, *Ca+2↑,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Total Targets: 0

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

Catalase↑, 1,   GPx3↑, 1,   GSR↑, 1,   SOD2↑, 1,  

Migration ⓘ

Ca+2↑, 1,   Cartilage↑, 1,   MMP9↓, 1,   TGF-β↑, 1,  

Angiogenesis & Vasculature ⓘ

NO↑, 1,   VEGF↑, 1,  

Immune & Inflammatory Signaling ⓘ

Inflam↓, 1,   PGE2↑, 1,  

Drug Metabolism & Resistance ⓘ

Dose↝, 1,  

Functional Outcomes ⓘ

Pain↓, 1,   QoL↑, 1,  
Total Targets: 15

Scientific Paper Hit Count for: GPx3, Glutathione Peroxidase 3
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:134  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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