Database Query Results : , , Maspin

Maspin, SERPINB5: Click to Expand ⟱
Source:
Type:
Maspin: Context-Dependent Tumor Suppressor, Invasion Control, and Prognostic Marker Maspin (mammary serine protease inhibitor), a member of the serpin family, is a non-inhibitory serine protease inhibitor with tumor suppressor activity.
-usually downregulated in cancers with low expression associated with poor prognosis.
Scientific Papers found: Click to Expand⟱
3421- TQ,    Insights into the molecular interactions of thymoquinone with histone deacetylase: evaluation of the therapeutic intervention potential against breast cancer
- Analysis, Nor, NA - in-vivo, Nor, NA - in-vitro, BC, MCF-7 - in-vitro, Nor, HaCaT
HDAC↓, P21↑, Maspin↑, BAX↑, B2M↓, TumCCA↑, selectivity↑, *toxicity↓, TumCMig↓, TumCP↓,
3423- TQ,    Epigenetic role of thymoquinone: impact on cellular mechanism and cancer therapeutics
- Review, Var, NA
AntiCan↑, Inflam↓, hepatoP↑, RenoP↑, BAX↑, Bak↑, Bcl-2↓, Bcl-xL↓, ROS↑, P53↑, PTEN↑, P21↑, p27↑, BRCA1↑, PI3K↓, Akt↓, MAPK↓, ERK↓, p‑ERK↓, MMPs↓, FAK↓, Twist↓, Zeb1↓, EMT↓, TumMeta↓, angioG↓, VEGF↓, HDAC↓, Maspin↑, SIRT1↑, DNMT1↓, DNMT3A↓, HDAC1↓, HDAC4↓,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

ROS↑, 1,  

Core Metabolism/Glycolysis ⓘ

SIRT1↑, 1,  

Cell Death ⓘ

Akt↓, 1,   Bak↑, 1,   BAX↑, 2,   Bcl-2↓, 1,   Bcl-xL↓, 1,   MAPK↓, 1,   p27↑, 1,  

DNA Damage & Repair ⓘ

BRCA1↑, 1,   DNMT1↓, 1,   DNMT3A↓, 1,   P53↑, 1,  

Cell Cycle & Senescence ⓘ

P21↑, 2,   TumCCA↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

EMT↓, 1,   ERK↓, 1,   p‑ERK↓, 1,   HDAC↓, 2,   HDAC1↓, 1,   HDAC4↓, 1,   PI3K↓, 1,   PTEN↑, 1,  

Migration ⓘ

FAK↓, 1,   MMPs↓, 1,   TumCMig↓, 1,   TumCP↓, 1,   TumMeta↓, 1,   Twist↓, 1,   Zeb1↓, 1,  

Angiogenesis & Vasculature ⓘ

angioG↓, 1,   VEGF↓, 1,  

Immune & Inflammatory Signaling ⓘ

B2M↓, 1,   Inflam↓, 1,  

Drug Metabolism & Resistance ⓘ

selectivity↑, 1,  

Clinical Biomarkers ⓘ

B2M↓, 1,   BRCA1↑, 1,   Maspin↑, 2,  

Functional Outcomes ⓘ

AntiCan↑, 1,   hepatoP↑, 1,   RenoP↑, 1,  
Total Targets: 41

Pathway results for Effect on Normal Cells:


Functional Outcomes ⓘ

toxicity↓, 1,  
Total Targets: 1

Scientific Paper Hit Count for: Maspin, SERPINB5
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1344  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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