Database Query Results : , , Bil

Bil, Bilirubin: Click to Expand ⟱
Source:
Type:
Bilirubin a yellow pigment formed by the breakdown of heme (from red blood cells), is traditionally known for its role in liver function and jaundice.
Bilirubin as an Antioxidant (Cancer Protection)
-Moderately elevated bilirubin levels are associated with reduced cancer risk
-Bilirubin or synthetic analogs (e.g. bilirubin nanoparticles) are being studied for, Cancer prevention, and Reducing chemo side effects via oxidative stress protection.

In contrast, very high bilirubin levels in patients often indicate:
-Liver metastasis or hepatocellular carcinoma (HCC)
Scientific Papers found: Click to Expand⟱
3714- FA,    Recent Advances in the Neuroprotective Properties of Ferulic Acid in Alzheimer's Disease: A Narrative Review
- Review, AD, NA
*antiOx↑, *Inflam↓, *neuroP↑, *NF-kB↓, *NLRP3↓, *iNOS↓, *COX2↓, *TNF-α↓, *IL1β↓, *VCAM-1↓, *ICAM-1↓, *p‑MAPK↓, *p38↓, *JNK↓, *IL6↓, *IL8↓, *hepatoP↑, *RenoP↑, *Catalase↑, *PPARγ↑, *ROS↓, *Fenton↓, *IronCh↑, *SOD↑, *MDA↓, *lipid-P↓, *NRF2↑, *HO-1↑, *ARE↑, *Bil↑, *radioP↑, *GCLC↑, *GCLM↑, *NQO1↑, *Half-Life↝, *GutMicro↑, *Aβ↓, *BDNF↑, *Ca+2↓, *lipid-P↓, *PGE2↓, *cognitive↑, *ChAT↑, *memory↑, *Dose↝, *toxicity↓,
3778- FA,    Recent Advances in the Neuroprotective Properties of Ferulic Acid in Alzheimer’s Disease: A Narrative Review
- Review, AD, NA
*neuroP↑, *Aβ↓, *antiOx↑, *Inflam↓, *ROS↓, *NF-kB↓, *NLRP3↓, *iNOS↓, *COX2↓, *TNF-α↓, *IL1β↓, *VCAM-1↓, *ICAM-1↓, *p‑MAPK?, *hepatoP↑, *TLR4↓, *PPARγ↑, *NRF2↑, *Fenton↓, *IronCh↑, *MDA↓, *HO-1↑, *Bil↑, *GCLC↑, *GCLM↑, *NQO1↑, *GutMicro↑, *SOD↑, *Ca+2↓, *lipid-P↓, *PGE2↓,
4022- FulvicA,  Chemo,    Shilajit potentiates the effect of chemotherapeutic drugs and mitigates metastasis induced liver and kidney damages in osteosarcoma rats
- in-vivo, OS, NA
AST↓, ALAT↓, ALP↓, Bil↝, creat↓, uricA↓, ChemoSen↑, chemoP↑,
3844- Moringa,    Review of the Safety and Efficacy of Moringa oleifera
- Review, NA, NA
*antiOx↑, *RenoP↑, *hepatoP↑, *radioP↑, *eff↑, *toxicity↓, *ROS↓, *lipid-P↓, *DNAdam↓, *Catalase↑, *SOD↑, *GPx↑, *GSR↑, *GSTs↑, *AST↓, *ALAT↓, *ALP↓, *Bil↓,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 4

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

Bil↝, 1,   uricA↓, 1,  

Core Metabolism/Glycolysis ⓘ

ALAT↓, 1,  

Drug Metabolism & Resistance ⓘ

ChemoSen↑, 1,  

Clinical Biomarkers ⓘ

ALAT↓, 1,   ALP↓, 1,   AST↓, 1,   Bil↝, 1,   creat↓, 1,  

Functional Outcomes ⓘ

chemoP↑, 1,  
Total Targets: 10

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 3,   ARE↑, 1,   Bil↓, 1,   Bil↑, 2,   Catalase↑, 2,   Fenton↓, 2,   GCLC↑, 2,   GCLM↑, 2,   GPx↑, 1,   GSR↑, 1,   GSTs↑, 1,   HO-1↑, 2,   lipid-P↓, 4,   MDA↓, 2,   NQO1↑, 2,   NRF2↑, 2,   ROS↓, 3,   SOD↑, 3,  

Metal & Cofactor Biology ⓘ

IronCh↑, 2,  

Core Metabolism/Glycolysis ⓘ

ALAT↓, 1,   PPARγ↑, 2,  

Cell Death ⓘ

iNOS↓, 2,   JNK↓, 1,   p‑MAPK?, 1,   p‑MAPK↓, 1,   p38↓, 1,  

DNA Damage & Repair ⓘ

DNAdam↓, 1,  

Migration ⓘ

Ca+2↓, 2,   VCAM-1↓, 2,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 2,   ICAM-1↓, 2,   IL1β↓, 2,   IL6↓, 1,   IL8↓, 1,   Inflam↓, 2,   NF-kB↓, 2,   PGE2↓, 2,   TLR4↓, 1,   TNF-α↓, 2,  

Synaptic & Neurotransmission ⓘ

BDNF↑, 1,   ChAT↑, 1,  

Protein Aggregation ⓘ

Aβ↓, 2,   NLRP3↓, 2,  

Drug Metabolism & Resistance ⓘ

Dose↝, 1,   eff↑, 1,   Half-Life↝, 1,  

Clinical Biomarkers ⓘ

ALAT↓, 1,   ALP↓, 1,   AST↓, 1,   Bil↓, 1,   Bil↑, 2,   GutMicro↑, 2,   IL6↓, 1,  

Functional Outcomes ⓘ

cognitive↑, 1,   hepatoP↑, 3,   memory↑, 1,   neuroP↑, 2,   radioP↑, 2,   RenoP↑, 2,   toxicity↓, 2,  
Total Targets: 60

Scientific Paper Hit Count for: Bil, Bilirubin
2 Ferulic acid
1 Shilajit/Fulvic Acid
1 Chemotherapy
1 Moringa oleifera
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1355  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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