Database Query Results : , , CDK5

CDK5, Cyclin-dependent kinase 5: Click to Expand ⟱
Source:
Type:
CDK5 is primarily expressed in neurons and is important for normal brain development, synaptic function, and neuronal signaling. However, CDK5 becomes dysregulated in AD, contributing to neurodegeneration. -CDK5 is generally upregulated or hyperactivated in both cancer and Alzheimer's disease (AD)
Scientific Papers found: Click to Expand⟱
3793- CUR,    Curcumin Downregulates GSK3 and Cdk5 in Scopolamine-Induced Alzheimer’s Disease Rats Abrogating Aβ40/42 and Tau Hyperphosphorylation
- in-vivo, AD, NA
*Aβ↓, *p‑tau↓, *GSK‐3β↓, *CDK5↓, *memory↑,
3794- CUR,    Curcumin hybrid molecules for the treatment of Alzheimer's disease: Structure and pharmacological activities
- Review, AD, NA
*GSK‐3β↓, *CDK5↓, *p‑tau↓, *IronCh↑, *ROS↓, *HO-1↑, *SOD↑, *Catalase↑, *GSH↑, *TNF-α↓, *IL6↓, *IL12↓, *NRF2↑, *PPARγ↑, *IL4↑, *AChE↓, *Dose↝, *GutMicro↑,
3795- CUR,    Curcumin: A Golden Approach to Healthy Aging: A Systematic Review of the Evidence
- Review, AD, NA
*antiOx↑, *Inflam↓, *AntiAge↑, *AMPK↑, *SIRT1↑, *NF-kB↓, *mTOR↓, *NLRP3↓, *NADPH↓, *ROS↓, *COX2↓, *MCP1↓, *IL1β↓, *IL17↓, *IL23↓, *TNF-α↓, *MPO↓, *IL10↑, *lipid-P↓, *SOD↑, *Aβ↓, *p‑tau↓, *GSK‐3β↓, *CDK5↓, *TXNIP↓, *NRF2↑, *NQO1↑, *HO-1↑, *OS↑, *memory↑, *BDNF↑, *neuroP↑, *BACE↓, *AChE↓, *LDL↓,
3728- MF,    Long-term exposure to ELF-MF ameliorates cognitive deficits and attenuates tau hyperphosphorylation in 3xTg AD mice
- in-vivo, AD, NA
*cognitive↑, *neuroP↑, *Apoptosis↓, *ROS↓, *p‑tau↓, *GSK‐3β↓, *CDK5↓,
3796- QC,  BBR,    Biomarker discovery and phytochemical interventions in Alzheimer's disease: A path to therapeutic advances
- Review, AD, NA
*CDK5↓,
3792- RosA,    Molecular docking and dynamics simulations revealed the potential inhibitory activity of honey-iQfood ingredients against GSK-3β and CDK5 protein targets for brain health
- Analysis, AD, NA
*CDK5↓, *GSK‐3β↓,
3948- Shank,    Neuroprotective role of Convolvulus pluricaulis on aluminium induced neurotoxicity in rat brain
- in-vivo, AD, NA
*AChE↓, *ChAT↑, *NGF↑, *CDK5↓, *neuroP↑, *MDA↓,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 7

Pathway results for Effect on Cancer / Diseased Cells:


Total Targets: 0

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 1,   Catalase↑, 1,   GSH↑, 1,   HO-1↑, 2,   lipid-P↓, 1,   MDA↓, 1,   MPO↓, 1,   NQO1↑, 1,   NRF2↑, 2,   ROS↓, 3,   SOD↑, 2,  

Metal & Cofactor Biology ⓘ

IronCh↑, 1,  

Core Metabolism/Glycolysis ⓘ

AMPK↑, 1,   LDL↓, 1,   NADPH↓, 1,   PPARγ↑, 1,   SIRT1↑, 1,  

Cell Death ⓘ

Apoptosis↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

GSK‐3β↓, 5,   mTOR↓, 1,  

Migration ⓘ

CDK5↓, 7,   TXNIP↓, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 1,   IL10↑, 1,   IL12↓, 1,   IL17↓, 1,   IL1β↓, 1,   IL23↓, 1,   IL4↑, 1,   IL6↓, 1,   Inflam↓, 1,   MCP1↓, 1,   NF-kB↓, 1,   TNF-α↓, 2,  

Synaptic & Neurotransmission ⓘ

AChE↓, 3,   BDNF↑, 1,   ChAT↑, 1,   NGF↑, 1,   p‑tau↓, 4,  

Protein Aggregation ⓘ

Aβ↓, 2,   BACE↓, 1,   NLRP3↓, 1,  

Drug Metabolism & Resistance ⓘ

Dose↝, 1,  

Clinical Biomarkers ⓘ

GutMicro↑, 1,   IL6↓, 1,  

Functional Outcomes ⓘ

AntiAge↑, 1,   cognitive↑, 1,   memory↑, 2,   neuroP↑, 3,   OS↑, 1,  
Total Targets: 50

Scientific Paper Hit Count for: CDK5, Cyclin-dependent kinase 5
3 Curcumin
1 Magnetic Fields
1 Quercetin
1 Berberine
1 Rosmarinic acid
1 Shankhpushpi
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1358  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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