Database Query Results : , , PDE4

PDE4, Phosphodiesterase 4: Click to Expand ⟱
Source:
Type:
Phosphodiesterase 4 (PDE4) has been increasingly implicated in the pathology of Alzheimer's Disease (AD), primarily due to its role in regulating cyclic AMP (cAMP) signaling in the brain.
-Hydrolyzes cAMP → AMP (thus decreasing cAMP levels)
-PDE4 inhibitors (like rolipram): Enhance memory in AD mouse models
Possible inhibitors:
Resveratrol, Baicalin, Luteolin, Quercetin, Apigenin, Icariin


Scientific Papers found: Click to Expand⟱
4986- ATV,  Dipy,    The combination of statins and dipyridamole is effective preclinically in AML, MM, and breast cancer
- Review, Var, NA
HMG-CoA↓, AntiAg↑, eff↑, Apoptosis↑, selectivity↑, *toxicity↓, TumCG↓, PDE4↓, other↑,
3785- Bor,    Discovery of boron-containing compounds as Aβ aggregation inhibitors and antioxidants for the treatment of Alzheimer's disease
- Analysis, AD, NA
*Aβ↓, *antiOx↑, *IronCh↑, *PDE4↓,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


Core Metabolism/Glycolysis ⓘ

HMG-CoA↓, 1,  

Cell Death ⓘ

Apoptosis↑, 1,  

Transcription & Epigenetics ⓘ

other↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

TumCG↓, 1,  

Migration ⓘ

AntiAg↑, 1,  

Drug Metabolism & Resistance ⓘ

eff↑, 1,   selectivity↑, 1,  

Functional Outcomes ⓘ

PDE4↓, 1,  
Total Targets: 8

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 1,  

Metal & Cofactor Biology ⓘ

IronCh↑, 1,  

Protein Aggregation ⓘ

Aβ↓, 1,  

Functional Outcomes ⓘ

PDE4↓, 1,   toxicity↓, 1,  
Total Targets: 5

Scientific Paper Hit Count for: PDE4, Phosphodiesterase 4
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1361  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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