Database Query Results : , , IDE

IDE, Insulin-Degrading Enzyme: Click to Expand ⟱
Source:
Type:
IDE, Insulin-Degrading Enzyme
-Reduced IDE activity in AD contributes to Aβ accumulation.
-Enhancing IDE activity or expression may reduce Aβ burden.
Scientific Papers found: Click to Expand⟱
4302- Gins,    Panax ginseng: A modulator of amyloid, tau pathology, and cognitive function in Alzheimer's disease
- Review, AD, NA
*neuroP↑, *Aβ↓, *p‑tau↓, *cognitive↑, *eff↑, *PKA↑, *CREB↑, *BACE↓, *ADAM10↑, *MAPK↑, *ERK↑, *PI3K↑, *Akt↑, *NRF2↑, *PPARγ↓, *IDE↑, *APP↓, *PP2A↑, *memory↑,
3835- Moringa,    Moringa Oleifera Alleviates Aβ Burden and Improves Synaptic Plasticity and Cognitive Impairments in APP/PS1 Mice
- in-vivo, AD, NA
*antiOx↑, *Inflam↓, *AChE↓, *neuroP↑, *Mood↑, *cognitive↑, *memory↑, *Aβ↓, *BACE↓, *AEP↓, *IDE↑, *NEP↑, *LRP1↑, *PSD95↑, *STEP↓, *APP↓,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


Total Targets: 0

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 1,   NRF2↑, 1,  

Core Metabolism/Glycolysis ⓘ

CREB↑, 1,   PPARγ↓, 1,  

Cell Death ⓘ

Akt↑, 1,   MAPK↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

ERK↑, 1,   PI3K↑, 1,  

Migration ⓘ

APP↓, 2,   LRP1↑, 1,   PKA↑, 1,  

Immune & Inflammatory Signaling ⓘ

Inflam↓, 1,  

Synaptic & Neurotransmission ⓘ

AChE↓, 1,   ADAM10↑, 1,   PSD95↑, 1,   p‑tau↓, 1,  

Protein Aggregation ⓘ

AEP↓, 1,   Aβ↓, 2,   BACE↓, 2,   IDE↑, 2,   NEP↑, 1,   PP2A↑, 1,  

Drug Metabolism & Resistance ⓘ

eff↑, 1,  

Functional Outcomes ⓘ

cognitive↑, 2,   memory↑, 2,   Mood↑, 1,   neuroP↑, 2,   STEP↓, 1,  
Total Targets: 28

Scientific Paper Hit Count for: IDE, Insulin-Degrading Enzyme
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1364  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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