Database Query Results : , , LRP1

LRP1, Low-Density Lipoprotein Receptor-Related Protein 1: Click to Expand ⟱
Source:
Type:
LRP1, Low-Density Lipoprotein Receptor-Related Protein 1
-LRP1 dysfunction or downregulation impairs Aβ clearance, contributing to amyloid pathology.
-involved in Aβ transport across the blood-brain barrier (BBB) and clearance via glial cells.

LRP1 supports malignancy by:
-Facilitating migration through integrin signaling
-Enhancing survival pathways (PI3K–AKT, ERK) in stressed tumor cells
-Modulating TGF-β signaling, which can promote EMT and immune evasion
-Supporting tumor–stroma crosstalk, especially via fibroblasts and macrophages


Scientific Papers found: Click to Expand⟱
3835- Moringa,    Moringa Oleifera Alleviates Aβ Burden and Improves Synaptic Plasticity and Cognitive Impairments in APP/PS1 Mice
- in-vivo, AD, NA
*antiOx↑, *Inflam↓, *AChE↓, *neuroP↑, *Mood↑, *cognitive↑, *memory↑, *Aβ↓, *BACE↓, *AEP↓, *IDE↑, *NEP↑, *LRP1↑, *PSD95↑, *STEP↓, *APP↓,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Total Targets: 0

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 1,  

Migration ⓘ

APP↓, 1,   LRP1↑, 1,  

Immune & Inflammatory Signaling ⓘ

Inflam↓, 1,  

Synaptic & Neurotransmission ⓘ

AChE↓, 1,   PSD95↑, 1,  

Protein Aggregation ⓘ

AEP↓, 1,   Aβ↓, 1,   BACE↓, 1,   IDE↑, 1,   NEP↑, 1,  

Functional Outcomes ⓘ

cognitive↑, 1,   memory↑, 1,   Mood↑, 1,   neuroP↑, 1,   STEP↓, 1,  
Total Targets: 16

Scientific Paper Hit Count for: LRP1, Low-Density Lipoprotein Receptor-Related Protein 1
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1366  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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