Database Query Results : , , DHA

DHA, docosahexaenoic acid: Click to Expand ⟱
Source:
Type:
DHA (docosahexaenoic acid; 22:6 n-3) is a long-chain omega-3 polyunsaturated fatty acid that functions less like a single “pathway enzyme” and more like a systems-level lipid signaling axis. Most commonly reported directions (context-dependent by dose, formulation, and tumor type):
-↑ Lipid peroxidation → ↑ ferroptosis susceptibility (anti-tumor)
DHA can increase lipid peroxides and promote ferroptotic tumor cell death in some models.
-↓ Proliferation / ↑ apoptosis (anti-tumor tendency)
Reviews summarize inhibition of growth and invasion and pro-apoptotic signaling across multiple cancers (heterogeneous evidence quality; not a universal effect).
Inflammation/eicosanoid “tilt” toward resolution
By shifting lipid mediator balance away from arachidonic-acid–derived pro-inflammatory mediators and toward SPMs, DHA can reduce pro-tumor inflammatory signaling in some contexts.
Big caveat: because DHA can drive oxidative lipid damage, the net effect depends heavily on antioxidant defenses (e.g., GPX4/GSH), iron handling, and whether the tumor is ferroptosis-sensitive.
Effects in Alzheimer’s disease (AD) and neurodegeneration

Mechanistically, DHA is highly relevant to brain biology, but clinical outcomes depend on disease stage:
-Structural/synaptic support (membrane axis)
DHA is a major brain omega-3 and supports membrane properties linked to synaptic function.
-↑ Pro-resolving lipid mediators → microglia modulation / inflammation resolution
SPMs derived from DHA are discussed as supporting a “pro-resolution” microglial phenotype and potentially improving amyloid handling (mechanistic/biomarker-level rationale).
-Clinical signal: more promising earlier (MCI) than established AD A 2023 review notes DHA supplementation shows benefit in some RCTs for mild cognitive impairment (MCI), but no consistent benefit in diagnosed Alzheimer’s disease.
A 2025 meta-analysis in AD similarly concludes omega-3 supplementation does not significantly improve cognition in adults with AD.
Scientific Papers found: Click to Expand⟱
3548- ALA,    How Alpha Linolenic Acid May Sustain Blood–Brain Barrier Integrity and Boost Brain Resilience against Alzheimer’s Disease
- Review, AD, NA
*BBB↑, *other↑, *other↑, *DHA↑, *neuroP↑, *ROS↓, *other?,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Total Targets: 0

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

ROS↓, 1,  

Core Metabolism/Glycolysis ⓘ

DHA↑, 1,  

Transcription & Epigenetics ⓘ

other?, 1,   other↑, 2,  

Barriers & Transport ⓘ

BBB↑, 1,  

Functional Outcomes ⓘ

neuroP↑, 1,  
Total Targets: 6

Scientific Paper Hit Count for: DHA, docosahexaenoic acid
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1379  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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