Database Query Results : , , PRNP

PRNP, Prion Protein (PRioN Protein) gene: Click to Expand ⟱
Source:
Type:
Prion Protein (PRioN Protein) gene
-Upregulation of PRNP → Activates PI3K/Akt, MAPK/ERK, and NF-κB pathways → ↑ cell survival, ↓ apoptosis, ↑ migration/invasion.
-Silencing or downregulation of PRNP often reduces tumor growth and increases chemosensitivity.
Scientific Papers found: Click to Expand⟱
4538- TQ,    Thymoquinone Anticancer Effects Through the Upregulation of NRF2 and the Downregulation of PD‐L1 in MDA‐MB‐231 Triple‐Negative Breast Cancer Cells
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, MDA-MB-468
antiOx↑, H2O2↓, Catalase↑, SOD↑, GSH↑, PRNP↑, NQO1↑, GCLM↑, NRF2↑, PD-L1↓, chemoPv↑, ROS↓,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned ⓘ

chemoPv↑, 1,  

Redox & Oxidative Stress ⓘ

antiOx↑, 1,   Catalase↑, 1,   GCLM↑, 1,   GSH↑, 1,   H2O2↓, 1,   NQO1↑, 1,   NRF2↑, 1,   ROS↓, 1,   SOD↑, 1,  

Migration ⓘ

PRNP↑, 1,  

Immune & Inflammatory Signaling ⓘ

PD-L1↓, 1,  

Clinical Biomarkers ⓘ

PD-L1↓, 1,  
Total Targets: 13

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: PRNP, Prion Protein (PRioN Protein) gene
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1380  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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