Database Query Results : , , miR-206

miR-206, miR-206: Click to Expand ⟱
Source:
Type:
miR-206 is a well-characterized tumor-suppressor microRNA that plays major roles in cell differentiation, EMT suppression, metastasis inhibition, and therapy sensitivity across many cancers. It is best known as a myomiR (muscle-specific miRNA), but in cancer its loss has broad oncogenic consequences.
-Cancer: frequently downregulated
-miR-206 is a potent EMT suppressor

curcumin, resveratrol, quercetin may upregulate miR-206
Scientific Papers found: Click to Expand⟱
4707- CUR,    The Potential Role of Curcumin as a Regulator of microRNA in Colorectal Cancer: A Systematic Review
- Review, Var, NA
miR-497↑, miR-200c↑, miR-409-3p↑, miR-34a↑, miR-126↑, miR-145↑, miR-206↑, miR-491↑, miR-141↑, miR-429↑, miR-101↑, miR-15↑, miR-21↓, miR-155↓, miR-221↓, miR‐222↓, miR-17↓, miR-130a↓, miR-27a-3p↓, miR-20↓,
4710- CUR,    miR-206_and_suppression_of_PI3KAKTmTOR_signaling_pathway">Curcumin inhibits migration and invasion of non-small cell lung cancer cells through up-regulation of miR-206 and suppression of PI3K/AKT/mTOR signaling pathway
- in-vitro, Lung, A549
TumCMig↓, TumCI↓, miR-206↑, p‑mTOR↓, p‑Akt↓,
5027- QC,    NRF2 Is Targeted By the Polyphenol Quercetin and Induces Apoptosis, in Part, through up Regulation of Pro Apoptotic Mirs
- in-vivo, AML, NA
HDAC4↓, NRF2↓, p‑NRF2↓, miR-133a-3p↑, miR-206↑,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 3

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

NRF2↓, 1,   p‑NRF2↓, 1,  

Cell Death ⓘ

p‑Akt↓, 1,   miR-497↑, 1,  

Transcription & Epigenetics ⓘ

miR-145↑, 1,   miR-21↓, 1,   miR-27a-3p↓, 1,   miR-409-3p↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

HDAC4↓, 1,   miR-101↑, 1,   miR-34a↑, 1,   miR-429↑, 1,   p‑mTOR↓, 1,  

Migration ⓘ

miR-130a↓, 1,   miR-133a-3p↑, 1,   miR-141↑, 1,   miR-155↓, 1,   miR-20↓, 1,   miR-200c↑, 1,   miR-206↑, 3,   miR-221↓, 1,   miR-491↑, 1,   miR‐222↓, 1,   TumCI↓, 1,   TumCMig↓, 1,  

Angiogenesis & Vasculature ⓘ

miR-126↑, 1,   miR-15↑, 1,   miR-17↓, 1,  
Total Targets: 28

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: miR-206, miR-206
2 Curcumin
1 Quercetin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1393  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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