Database Query Results : , , SLC1A5

SLC1A5, SLC1A5: Click to Expand ⟱

Source:

Type:

SLC1A5 encodes ASCT2, a high-capacity glutamine transporter located on the plasma membrane. Its physiologic role is to mediate sodium-dependent exchange of neutral amino acids, with glutamine as the dominant substrate.
-Commonly UPREGULATED in many cancers.
-Upregulation reflects glutamine dependence (“glutamine addiction”) rather than mutation.

Scientific Papers found: Click to Expand⟱

5026-

QC,

Quercetin induces ferroptosis in gastric cancer cells by targeting SLC1A5 and regulating the p-Camk2/p-DRP1 and NRF2/GPX4 Axes

in-vitro,

GC,

SLC1A5↓, ROS↑, Iron↓, NRF2↓, GPx4↓, Ferroptosis↑,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:

Redox & Oxidative Stress ⓘ

Ferroptosis↑, 1, GPx4↓, 1, Iron↓, 1, NRF2↓, 1, ROS↑, 1,

Core Metabolism/Glycolysis ⓘ

SLC1A5↓, 1,

Cell Death ⓘ

Ferroptosis↑, 1,
Total Targets: 7

Pathway results for Effect on Normal Cells:

Total Targets: 0

Scientific Paper Hit Count for: SLC1A5, SLC1A5

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells