Database Query Results : , , HIF-1

HIF-1, HIF-1 signaling: Click to Expand ⟱
Source: HalifaxProj(inhibit)
Type:
Hypoxia-inducible factor 1 (HIF-1) is a transcription factor that plays a crucial role in cellular responses to low oxygen levels (hypoxia). It is composed of two subunits: HIF-1α and HIF-1β. Under normal oxygen conditions, HIF-1α is rapidly degraded, but in hypoxic conditions, it stabilizes, translocates to the nucleus, and dimerizes with HIF-1β to activate the transcription of various genes involved in processes such as angiogenesis, metabolism, and cell survival.
HIF-1α is often overexpressed due to the hypoxic microenvironment created by rapid tumor growth and inadequate blood supply. This upregulation allows cancer cells to adapt to low oxygen levels. HIF-1 regulates the expression of numerous target genes involved in angiogenesis (e.g., VEGF), glucose metabolism (e.g., GLUT1), cell survival, and invasion. The activation of these genes promotes tumor growth and metastasis.
However, HIF-1 is expressed in pathological conditions such as cancer and obesity.
Scientific Papers found: Click to Expand⟱
257- AL,  Cisplatin,    Allicin Overcomes Hypoxia Mediated Cisplatin Resistance in Lung Cancer Cells through ROS Mediated Cell Death Pathway and by Suppressing Hypoxia Inducible Factors
- in-vitro, NSCLC, A549
ROS↑, HIF-1↓, E-cadherin↑, N-cadherin↓, antiOx↓, Dose↝,
696- Bor,    Nothing Boring About Boron
- Review, Var, NA
*hs-CRP↓, *TNF-α↓, *SOD↑, *Catalase↑, *GPx↑, *cognitive↑, *memory↑, *Risk↓, *SAM-e↑, *NAD↝, *ATP↝, *Ca+2↝, HDAC↓, TumVol↓, IGF-1↓, PSA↓, Cyc↓, TumCMig↓, *serineP↓, HIF-1↓, *ChemoSideEff↓, *VitD↑, *Mag↑, *eff↑, Risk↓, *Inflam↓, *neuroP↑, *Calcium↑, *BMD↑, *chemoP↑, AntiCan↑, *Dose↑, *Dose↝, *BMPs↑, *testos↑, angioG↓, Apoptosis↑, *selectivity↑, *chemoPv↑,
1416- Bos,    Anti-cancer properties of boswellic acids: mechanism of action as anti-cancerous agent
- Review, NA, NA
5LO↓, TumCCA↑, LC3B↓, PI3K↓, Akt↓, Glycolysis↓, AMPK↑, mTOR↓, Let-7↑, COX2↓, VEGF↓, CXCR4↓, MMP2↓, MMP9↓, HIF-1↓, angioG↓, TumCP↓, TumCMig↓, NF-kB↓,
140- CUR,    Curcumin inhibits cancer-associated fibroblast-driven prostate cancer invasion through MAOA/mTOR/HIF-1α signaling
- in-vitro, Pca, PC3
CAFs/TAFs↓, EMT↓, ROS↓, CXCR4↓, IL6↓, MAOA↓, mTOR↓, HIF-1↓,
19- Deg,    Deguelin inhibits proliferation and migration of human pancreatic cancer cells in vitro targeting hedgehog pathway
- in-vitro, PC, Bxpc-3 - in-vitro, PC, PANC1
HH↓, Gli1↓, PTCH1↓, Sufu↓, MMP2↓, MMP9↓, PI3K/Akt↓, HIF-1↓, VEGF↓, IKKα↓, NF-kB↓, EMT↓, AMPK↑, mTOR↓, survivin↓,
682- EGCG,    Suppressive Effects of EGCG on Cervical Cancer
- Review, NA, NA
E7↓, E6↓, PI3K/Akt↓, P53↑, p27↑, P21↑, CDK2↓, mTOR↓, HIF-1↓, IGF-1↓, EGFR↓, ERK↓, VEGF↓,
950- EMD,    Emodin Decreases Hepatic Hypoxia-Inducible Factor-1[Formula: see text] by Inhibiting its Biosynthesis
- in-vivo, NA, NA - in-vitro, Liver, HepG2
HIF-1↓,
845- Gra,    A Review on Annona muricata and Its Anticancer Activity
- Review, NA, NA
GlucoseCon↓, ATP↓, HIF-1↓, GLUT1↓, GLUT4↓, HK2↓, LDHA↓, ERK↓, Akt↓, Apoptosis↑, NF-kB↓, ROS↑, Bax:Bcl2↑, MMP↓, Casp3↑, Casp9↑, p‑JNK↓,
973- LT,    Luteolin impairs hypoxia adaptation and progression in human breast and colon cancer cells
- in-vitro, CRC, HCT116 - in-vitro, BC, MDA-MB-231
Apoptosis↑, necrosis↑, TumAuto↑, HIF-1↓,
194- MF,    Electromagnetic Field as a Treatment for Cerebral Ischemic Stroke
- Review, Stroke, NA
*BAD↓, *BAX↓, *Casp3↓, *Bcl-xL↑, *p‑Akt↑, *MMP9↓, *p‑ERK↑, *HIF-1↓, *ROS↓, *VEGF↑, *Ca+2↓, *SOD↑, *IL2↑, *p38↑, *HSP70/HSPA5↑, *Apoptosis↓, *ROS↓, *NO↓,
4626- OLE,    A Comprehensive Review on the Anti-Cancer Effects of Oleuropein
- Review, Var, NA
Risk↓, Dose↑, TumCP↓, NF-kB↓, COX2↓, Akt↓, P53↑, BAX↑, Bcl-2↓, HIF-1↓, ROS↑, HO-1↑, chemoP↑, TumCCA↑, FASN↓,
3348- QC,    Quercetin and iron metabolism: What we know and what we need to know
- Review, NA, NA
*IronCh↑, *ROS↓, *AntiAg↑, *Fenton↓, *lipid-P↓, *hepatoP↑, *RenoP↑, HIF-1↑, ROS↑,
39- QC,    A Comprehensive Analysis and Anti-Cancer Activities of Quercetin in ROS-Mediated Cancer and Cancer Stem Cells
- Analysis, NA, NA
ROS↑, GSH↓, IL6↓, COX2↓, IL8↓, iNOS↓, TNF-α↓, MAPK↑, ERK↑, SOD↑, ATP↓, Casp↑, PI3K/Akt↓, mTOR↓, NOTCH1↓, Bcl-2↓, BAX↑, IFN-γ↓, TumCP↓, TumCCA↑, Akt↓, P70S6K↓, *Keap1↓, *GPx↑, *Catalase↑, *HO-1↑, *NRF2↑, NRF2↑, eff↑, HIF-1↓,
3323- SIL,    Anticancer therapeutic potential of silibinin: current trends, scope and relevance
- Review, Var, NA
Inflam↓, angioG↓, antiOx↑, TumMeta↓, TumCP↓, TumCCA↑, TumCD↑, α-SMA↓, p‑Akt↓, p‑STAT3↓, COX2↓, IL6↓, MMP2↓, HIF-1↓, Snail↓, Slug↓, Zeb1↓, NF-kB↓, p‑EGFR↓, JAK2↓, PI3K↓, PD-L1↓, VEGF↓, CDK4↓, CDK2↓, cycD1/CCND1↓, E2Fs↓,
392- SNP,    HIF-1aVEGF_mediated_angiogenesis_in_prostate_cancer_cells">Biogenic silver nanoparticles synthesized from Piper longum fruit extract inhibit HIF-1α/VEGF mediated angiogenesis in prostate cancer cells
VEGF↓, HIF-1↓,
366- SNP,    Silver nanoparticles inhibit the function of hypoxia-inducible factor-1 and target genes: insight into the cytotoxicity and antiangiogenesis
- in-vitro, BC, MCF-7
HIF-1↓, Hif1a↓, VEGF↓, GLUT1↓,
4549- SNP,    Silver nanoparticles: Synthesis, medical applications and biosafety
- Review, Var, NA - Review, Diabetic, NA
ROS↑, eff↑, other↝, DNAdam↑, EPR↑, eff↑, eff↑, TumMeta↓, angioG↓, *Bacteria↓, *eff↑, *AntiViral↑, *AntiFungal↑, eff↑, eff↑, TumCP↓, tumCV↓, P53↝, HIF-1↓, TumCCA↑, lipid-P↑, ATP↓, Cyt‑c↑, MMPs↓, PI3K↓, Akt↓, *Wound Healing↑, *Inflam↓, *Bone Healing↑, *glucose↓, *AntiDiabetic↑, *BBB↑,
3104- VitC,    Pro- and Antioxidant Effects of Vitamin C in Cancer in correspondence to Its Dietary and Pharmacological Concentrations
*antiOx↑, *ROS↓, *DNAdam↓, ROS↑, TET1↑, CSCs↓, HIF-1↓, BioAv↑, selectivity↑,
961- Z,    Zinc Downregulates HIF-1α and Inhibits Its Activity in Tumor Cells In Vitro and In Vivo
- in-vitro, RCC, RCC4 - vitro+vivo, GBM, U373MG - in-vitro, Nor, HUVECs
Hif1a↓, HIF-1↓, VEGF↓, TumCI↓,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 19

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

antiOx↓, 1,   antiOx↑, 1,   GSH↓, 1,   HO-1↑, 1,   lipid-P↑, 1,   NRF2↑, 1,   ROS↓, 1,   ROS↑, 7,   SOD↑, 1,  

Mitochondria & Bioenergetics ⓘ

ATP↓, 3,   MMP↓, 1,  

Core Metabolism/Glycolysis ⓘ

AMPK↑, 2,   FASN↓, 1,   GlucoseCon↓, 1,   Glycolysis↓, 1,   HK2↓, 1,   LDHA↓, 1,   PI3K/Akt↓, 3,  

Cell Death ⓘ

Akt↓, 5,   p‑Akt↓, 1,   Apoptosis↑, 3,   BAX↑, 2,   Bax:Bcl2↑, 1,   Bcl-2↓, 2,   Casp↑, 1,   Casp3↑, 1,   Casp9↑, 1,   Cyt‑c↑, 1,   iNOS↓, 1,   p‑JNK↓, 1,   MAPK↑, 1,   necrosis↑, 1,   p27↑, 1,   survivin↓, 1,   TumCD↑, 1,  

Transcription & Epigenetics ⓘ

other↝, 1,   tumCV↓, 1,  

Autophagy & Lysosomes ⓘ

LC3B↓, 1,   TumAuto↑, 1,  

DNA Damage & Repair ⓘ

DNAdam↑, 1,   P53↑, 2,   P53↝, 1,  

Cell Cycle & Senescence ⓘ

CDK2↓, 2,   CDK4↓, 1,   Cyc↓, 1,   cycD1/CCND1↓, 1,   E2Fs↓, 1,   P21↑, 1,   TumCCA↑, 5,  

Proliferation, Differentiation & Cell State ⓘ

CSCs↓, 1,   EMT↓, 2,   ERK↓, 2,   ERK↑, 1,   Gli1↓, 1,   HDAC↓, 1,   HH↓, 1,   IGF-1↓, 2,   Let-7↑, 1,   mTOR↓, 5,   NOTCH1↓, 1,   P70S6K↓, 1,   PI3K↓, 3,   PTCH1↓, 1,   p‑STAT3↓, 1,   Sufu↓, 1,  

Migration ⓘ

5LO↓, 1,   CAFs/TAFs↓, 1,   E-cadherin↑, 1,   MMP2↓, 3,   MMP9↓, 2,   MMPs↓, 1,   N-cadherin↓, 1,   Slug↓, 1,   Snail↓, 1,   TET1↑, 1,   TumCI↓, 1,   TumCMig↓, 2,   TumCP↓, 5,   TumMeta↓, 2,   Zeb1↓, 1,   α-SMA↓, 1,  

Angiogenesis & Vasculature ⓘ

angioG↓, 4,   EGFR↓, 1,   p‑EGFR↓, 1,   EPR↑, 1,   HIF-1↓, 17,   HIF-1↑, 1,   Hif1a↓, 2,   VEGF↓, 7,  

Barriers & Transport ⓘ

GLUT1↓, 2,   GLUT4↓, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 4,   CXCR4↓, 2,   IFN-γ↓, 1,   IKKα↓, 1,   IL6↓, 3,   IL8↓, 1,   Inflam↓, 1,   JAK2↓, 1,   NF-kB↓, 5,   PD-L1↓, 1,   PSA↓, 1,   TNF-α↓, 1,  

Synaptic & Neurotransmission ⓘ

MAOA↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↑, 1,   Dose↑, 1,   Dose↝, 1,   eff↑, 6,   selectivity↑, 1,  

Clinical Biomarkers ⓘ

E6↓, 1,   E7↓, 1,   EGFR↓, 1,   p‑EGFR↓, 1,   IL6↓, 3,   PD-L1↓, 1,   PSA↓, 1,  

Functional Outcomes ⓘ

AntiCan↑, 1,   chemoP↑, 1,   Risk↓, 2,   TumVol↓, 1,  
Total Targets: 120

Pathway results for Effect on Normal Cells:


NA, unassigned ⓘ

chemoPv↑, 1,  

Redox & Oxidative Stress ⓘ

antiOx↑, 1,   Catalase↑, 2,   Fenton↓, 1,   GPx↑, 2,   HO-1↑, 1,   Keap1↓, 1,   lipid-P↓, 1,   NRF2↑, 1,   ROS↓, 4,   SAM-e↑, 1,   SOD↑, 2,  

Metal & Cofactor Biology ⓘ

IronCh↑, 1,  

Mitochondria & Bioenergetics ⓘ

ATP↝, 1,  

Core Metabolism/Glycolysis ⓘ

glucose↓, 1,   NAD↝, 1,  

Cell Death ⓘ

p‑Akt↑, 1,   Apoptosis↓, 1,   BAD↓, 1,   BAX↓, 1,   Bcl-xL↑, 1,   Casp3↓, 1,   p38↑, 1,  

Protein Folding & ER Stress ⓘ

HSP70/HSPA5↑, 1,  

DNA Damage & Repair ⓘ

DNAdam↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

p‑ERK↑, 1,  

Migration ⓘ

AntiAg↑, 1,   Ca+2↓, 1,   Ca+2↝, 1,   MMP9↓, 1,   serineP↓, 1,  

Angiogenesis & Vasculature ⓘ

HIF-1↓, 1,   NO↓, 1,   VEGF↑, 1,  

Barriers & Transport ⓘ

BBB↑, 1,  

Immune & Inflammatory Signaling ⓘ

IL2↑, 1,   Inflam↓, 2,   TNF-α↓, 1,   VitD↑, 1,  

Hormonal & Nuclear Receptors ⓘ

testos↑, 1,  

Drug Metabolism & Resistance ⓘ

Dose↑, 1,   Dose↝, 1,   eff↑, 2,   selectivity↑, 1,  

Clinical Biomarkers ⓘ

BMD↑, 1,   BMPs↑, 1,   Calcium↑, 1,   hs-CRP↓, 1,   Mag↑, 1,   VitD↑, 1,  

Functional Outcomes ⓘ

AntiDiabetic↑, 1,   Bone Healing↑, 1,   chemoP↑, 1,   ChemoSideEff↓, 1,   cognitive↑, 1,   hepatoP↑, 1,   memory↑, 1,   neuroP↑, 1,   RenoP↑, 1,   Risk↓, 1,   Wound Healing↑, 1,  

Infection & Microbiome ⓘ

AntiFungal↑, 1,   AntiViral↑, 1,   Bacteria↓, 1,  
Total Targets: 64

Scientific Paper Hit Count for: HIF-1, HIF-1 signaling
3 Silver-NanoParticles
2 Quercetin
1 Allicin (mainly Garlic)
1 Cisplatin
1 Boron
1 Boswellia (frankincense)
1 Curcumin
1 Deguelin
1 EGCG (Epigallocatechin Gallate)
1 Emodin
1 Graviola
1 Luteolin
1 Magnetic Fields
1 Oleuropein
1 Silymarin (Milk Thistle) silibinin
1 Vitamin C (Ascorbic Acid)
1 Zinc
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:142  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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