Database Query Results : , , Leptin

Leptin, Leptin: Click to Expand ⟱
Source:
Type:
Leptin is an adipokine elevated in obesity.
Many tumors overexpress the leptin receptor (Ob-R), creating autocrine/paracrine signaling loops.
Leptin acts as a pro-oncogenic signal integrator, linking:
-Adiposity
-Inflammation
-Growth factor signaling
-Metabolic reprogramming

1.Circulating leptin (systemic)
-Upregulated in obesity, which strongly correlates with higher cancer risk and worse outcomes in several tumor types.
-This creates a permissive, pro-tumor systemic environment.
2.Tumor leptin receptor (Ob-R) expression
-Frequently upregulated in tumors (and tumor stroma), even when circulating leptin is only modestly elevated.
-Leads to hypersensitivity to leptin.
3.Autocrine/paracrine leptin production
-Many tumors produce leptin locally, independent of adipose tissue.
-Establishes a self-reinforcing growth loop.
4.Downstream leptin signaling
-Consistently upregulated:
  -JAK2 → STAT3
  -PI3K → AKT → mTOR
  -APK/ERK
  -NF-κB
-These pathways drive proliferation, survival, angiogenesis, EMT, and therapy resistance.


Scientific Papers found: Click to Expand⟱
5192- dietMet,    Intermittent methionine restriction reduces IGF‐1 levels and produces similar healthspan benefits to continuous methionine restriction
OS↑, eff↝, IGF-1↓, adiP↑, Leptin↓, Weight↓,
5055- Ex,    Why exercise has a crucial role in cancer prevention, risk reduction and improved outcomes
- Review, Var, NA
OS↑, IGF-1↓, IGFBP3↑, BRCA1↑, BRCA2↑, RAS↓, P53↑, HSPs↑, Leptin↓, Irisin↓, Resistin↓, NK cell↑, CRP↓, IL6↓, TNF-α↓, PGE1↓, COX2↓, *GSH↑, *Catalase↑, *SOD↑, *monoA↑, *EndoR↑, *testos↑, ROS↑, QoL↑, BMD↑, BowelM↑,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned ⓘ

Irisin↓, 1,   Leptin↓, 2,   Resistin↓, 1,  

Redox & Oxidative Stress ⓘ

ROS↑, 1,  

Core Metabolism/Glycolysis ⓘ

adiP↑, 1,  

Transcription & Epigenetics ⓘ

BowelM↑, 1,  

Protein Folding & ER Stress ⓘ

HSPs↑, 1,  

DNA Damage & Repair ⓘ

BRCA1↑, 1,   BRCA2↑, 1,   P53↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

IGF-1↓, 2,   IGFBP3↑, 1,   RAS↓, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 1,   CRP↓, 1,   IL6↓, 1,   NK cell↑, 1,   PGE1↓, 1,   TNF-α↓, 1,  

Drug Metabolism & Resistance ⓘ

eff↝, 1,  

Clinical Biomarkers ⓘ

BMD↑, 1,   BRCA1↑, 1,   CRP↓, 1,   IL6↓, 1,  

Functional Outcomes ⓘ

OS↑, 2,   QoL↑, 1,   Weight↓, 1,  
Total Targets: 27

Pathway results for Effect on Normal Cells:


NA, unassigned ⓘ

EndoR↑, 1,  

Redox & Oxidative Stress ⓘ

Catalase↑, 1,   GSH↑, 1,   SOD↑, 1,  

Synaptic & Neurotransmission ⓘ

monoA↑, 1,  

Hormonal & Nuclear Receptors ⓘ

testos↑, 1,  
Total Targets: 6

Scientific Paper Hit Count for: Leptin, Leptin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1421  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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